Results 31 to 40 of about 1,598,338 (286)
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012 Despite fluctuations in dietary iron intake and intermittent losses through bleeding, the plasma iron concentrations in humans remain stable at 10-30 μM. While most of the iron entering blood plasma comes from recycling, appropriate amount of iron is absorbed from the diet to compensate for losses and maintain nontoxic amounts in stores.
Ganz, Tomas, Nemeth, Elizabeta
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Metalloreductase Steap3 coordinates the regulation of iron homeostasis and inflammatory responses
Haematologica, 2012 Background Iron and its homeostasis are intimately related to inflammatory responses, but the underlying molecular mechanisms are poorly understood. We investigated the role of Steap3 in regulating iron homeostasis in macrophages, and the effects of ...
Fan Zhang +8 more
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Antioxidants, 2021 Iron accumulation and neuroinflammation are pathological conditions found in several neurodegenerative diseases, including Alzheimer’s disease (AD) and Parkinson’s disease (PD). Iron and inflammation are intertwined in a bidirectional relationship, where
Pamela J. Urrutia +2 more
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Iron homeostasis imbalance and ferroptosis in brain diseases
MedComm, 2023 Brain iron homeostasis is maintained through the normal function of blood–brain barrier and iron regulation at the systemic and cellular levels, which is fundamental to normal brain function.
Haining Long +3 more
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Gestational diabetes mellitus affects placental iron homeostasis: Mechanism and clinical implications. [PDF]
, 2020 Clinical studies suggest that pregnant women with elevated iron levels are more vulnerable to develop gestational diabetes mellitus (GDM), but the causes and underlying mechanisms are unknown.
Melhem, Hassan +23 more
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Iron species in iron homeostasis and toxicity
The Analyst, 1995 Iron homeostasis in prokaryotic cells appears to be regulated essentially at the level of the genome by the Fur protein. When iron is in short supply the uptake and assimilation pathways are de-repressed and siderophores are synthesized together with the outer, inner (plasma) membrane, periplasmic and cytosolic components necessary for the uptake of ...
Crichton, Robert, Ward, Roberta J.
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Mechanisms of Mammalian Iron Homeostasis [PDF]
Biochemistry, 2012 Iron is vital for almost all organisms because of its ability to donate and accept electrons with relative ease. It serves as a cofactor for many proteins and enzymes necessary for oxygen and energy metabolism, as well as for several other essential processes. Mammalian cells utilize multiple mechanisms to acquire iron.
Kostas, Pantopoulos +3 more
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PLoS Pathogens, 2019 Iron homeostasis is important for growth, reproduction and other metabolic processes in all eukaryotes. However, the functions of ATP-binding cassette (ABC) transporters in iron homeostasis are largely unknown.
Zhihui Wang +7 more
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Alterations of iron metabolism during heart ischemia/reperrfusion injury. Cytoprotective effects of Simvastatin. [PDF]
, 2011 Ischemic heart disease, the main cause of mortality and morbidity in industrialized countries, is a metabolic phenomenon due to an inadequate oxygenation of heart tissue caused by the closing or narrowing of the coronary arteries.
Di Pascale, Antonio
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The Role of Sulfur in Agronomic Biofortification with Essential Micronutrients
Plants, 2022 Sulfur (S) is an essential macronutrient for plants, being necessary for their growth and metabolism and exhibiting diverse roles throughout their life cycles. Inside the plant body, S is present either in one of its inorganic forms or incorporated in an
Styliani N. Chorianopoulou +1 more
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