Interaction of hemojuvelin with neogenin results in iron accumulation in human embryonic kidney 293 cells [PDF]
, 2005 Type 2 hereditary hemochromatosis (HH) or juvenile hemochromatosis is an early onset, genetically heterogeneous, autosomal recessive disorder of iron overload.
Bjorkman, Pamela J. +4 more
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De Toro, Alfonso; Ceballos, René (eds.) (2014).Frida Kahlo ‘revisitada’: Estrategias transmediales- transculturales - transpicturales. Hildesheim; Zürich; New York: Georg Olms Verlag, pp. 193 [PDF]
, 2015 Iron is an essential element, since it is a component of many macromolecules involved in diverse physiological and cellular functions, including oxygen transport, cellular growth, and metabolism.
Rishi, G. +3 more
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PLoS Pathogens, 2019 Iron homeostasis is important for growth, reproduction and other metabolic processes in all eukaryotes. However, the functions of ATP-binding cassette (ABC) transporters in iron homeostasis are largely unknown.
Zhihui Wang +7 more
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Antioxidants, 2023 Iron is essential for life. Many enzymes require iron for appropriate function. However, dysregulation of intracellular iron homeostasis produces excessive reactive oxygen species (ROS) via the Fenton reaction and causes devastating effects on cells ...
Jaewang Lee, Dong-Hoon Hyun
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Mechanisms of Mammalian Iron Homeostasis [PDF]
Biochemistry, 2012 Iron is vital for almost all organisms because of its ability to donate and accept electrons with relative ease. It serves as a cofactor for many proteins and enzymes necessary for oxygen and energy metabolism, as well as for several other essential processes. Mammalian cells utilize multiple mechanisms to acquire iron.
Kostas, Pantopoulos +3 more
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Direct activation of genes involved in intracellular iron use by the yeast iron-responsive transcription factor Aft2 without its paralog Aft1. [PDF]
, 2005 The yeast Saccharomyces cerevisiae contains a pair of paralogous iron-responsive transcription activators Aft1 and Aft2. Aft1 activates the cell-surface iron uptake systems in iron depletion while the role of Aft2 remains poorly understood.
Courel, Maïte +3 more
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Frontiers in Genetics, 2022 Due to iron’s essential role in cellular metabolism, most organisms must maintain their homeostasis. In this regard, the fission yeast Schizosaccharomyces pombe (sp) uses two transcription factors to regulate intracellular iron levels: spFep1 under iron ...
Alia Ebrahim +8 more
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OPT3 is a component of the iron-signaling network between leaves and roots and misregulation of OPT3 leads to an over-accumulation of cadmium in seeds. [PDF]
, 2014 Plants and seeds are the main dietary sources of zinc, iron, manganese, and copper, but are also the main entry point for toxic elements such as cadmium into the food chain. We report here that an Arabidopsis oligopeptide transporter mutant, opt3-2, over-
Akmakjian, Garo Z +10 more
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Haptoglobin Polymorphism and Iron Homeostasis [PDF]
Clinical Chemistry, 2002 Abstract Background: There is a marked difference in the degree of expression of the homozygous C282Y HFE genotype that is associated with hereditary hemochromatosis. It has been reported that individuals with the haptoglobin 2-2 type manifest increased iron concentrations, including serum iron, transferrin saturation, and ferritin.
Ernest, Beutler +2 more
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Duodenal Lamina Propria Transferrin—A New Player in the Mucosal Block of Dietary Iron Absorption? [PDF]
Indian Journal of Medical BiochemistryIron is an essential trace element, and its homeostasis is subjected to strict regulatory mechanisms. Hepcidin, a liver synthesized antimicrobial peptide, is the master regulator of systemic iron homeostasis.
Jagadish Ramasamy
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