Results 71 to 80 of about 1,598,338 (286)

Regulation of iron homeostasis by Fur and atypical response regulator SsoR via derepressor-inhibitor oscillation in Shewanella oneidensis

Applied and Environmental Microbiology
Iron is a vital cofactor for enzymes essential to many biological processes, yet in excess, it poses a danger to all living organisms. In order to ensure survival and proliferation under fluctuating environmental iron levels, bacteria evolve ...
Kaiyue Jie, Xinyue Liu, Jiyuan Hou, Peilu Xie, Jiaxin Tang, Haichun Gao   +5 more
doaj   +1 more source

Coordination of hypoxia adaptation and iron homeostasis in pathogenic fungi

Frontiers in Microbiology, 2012
In mammals, hypoxia causes facilitated erythropoiesis that requires increased iron availability with established links between oxygen and iron in regulation of the transcription factor hypoxia inducible factor (HIF).
Dawoon eChung, Hubertus eHaas, Robert A Cramer   +2 more
doaj   +1 more source

Schizosaccharomyces pombe Grx4, Fep1, and Php4: In silico analysis and expression response to different iron concentrations

Frontiers in Genetics, 2022
Due to iron’s essential role in cellular metabolism, most organisms must maintain their homeostasis. In this regard, the fission yeast Schizosaccharomyces pombe (sp) uses two transcription factors to regulate intracellular iron levels: spFep1 under iron ...
Alia Ebrahim, Manal A. Alfwuaires, Mohammad H. Abukhalil, Mohammad H. Abukhalil, Fawaz Alasmari, Fawad Ahmad, Rui Yao, Ying Luo, Ying Huang   +8 more
doaj   +1 more source

Magnetoreceptor Promotes Hepatocellular Carcinoma Development and Blunts Sorafenib-Induced Ferroptosis by Regulating Iron Homeostasis. [PDF]

Adv Sci (Weinh)
Magnetoreceptor (MagR) regulates iron homeostasis and mitochondrial function in hepatocellular carcinoma (HCC) cells. Specifically, MagR deficiency suppresses tumor cell proliferation, migration, and invasion and enhances sorafenib‐induced ferroptosis through iron accumulation.
Wang T, Song C, He X, Wang M, Liu W, Wang X, Zhang Y, Zhang J, Zhang L, Li D, Zhang Y, Wu Z, Lyu Y, Wu R.   +13 more
europepmc   +2 more sources

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Calcineurin signaling and membrane lipid homeostasis regulates iron mediated multidrug resistance mechanisms in Candida albicans. [PDF]

PLoS ONE, 2011
We previously demonstrated that iron deprivation enhances drug susceptibility of Candida albicans by increasing membrane fluidity which correlated with the lower expression of ERG11 transcript and ergosterol levels.
Saif Hameed, Sanjiveeni Dhamgaye, Ashutosh Singh, Shyamal K Goswami, Rajendra Prasad   +4 more
doaj   +1 more source

The effect of iron on hepatitis C virus replication [PDF]

, 2011
Hepatitis C virus (HCV) is a small RNA encoded virus that causes acute and chronic infections of the liver and is associated with fibrosis, cirrhosis, hepatocellular carcinoma and end-stage liver disease.
Clark, Hayley
core  

Selective elimination of quiescent cancer cells by dequalinium chloride via ROS‐mediated ferroptosis

FEBS Open Bio, EarlyView.
Dequalinium chloride (DQ) selectively eliminates quiescent cancer cells (QCCs) by amplifying mitochondrial ROS. QCCs exhibit elevated basal ROS and limited redox‐buffering capacity, making them vulnerable to further ROS increases. DQ‐induced ROS exceeds the tolerance threshold, triggering lipid peroxidation and ferroptosis, whereas proliferating cells ...
Kotaro Miyamoto, Shiori Sakai, Minori Endo, Terigele, Mizuho Niibori, Taiki Morita, Yu Goto, Arisa Yoshida, Tomohiro Tanaka, Ning Lin, Takahiro Kuchimaru, Hiroyuki Nakamura, Masahiro Inoue, Shinae Kizaka‐Kondoh, Tetsuya Kadonosono   +14 more
wiley   +1 more source

The control of iron homeostasis: microRNAS join the party

, 2011
Castoldi M, Spasic MV, Altamura S, et al. (Department of Pediatric Hematology, Oncology, and Immunology, University of Heidelberg, Heidelberg, Germany; others). The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. J Clin Invest
Wallace, Daniel F., Subramaniam, V. Nathan, Darrell H.G. Crawford, V. Nathan Subramaniam, Crawford, Darrell H.G., Daniel F. Wallace   +5 more
core   +1 more source

Remote Activation of Wnt Signaling and Cell Proliferation by E‐Cadherin Magnetomechanical Stimulation

Advanced Functional Materials, EarlyView.
A pioneering magnetogenetic toolkit enables non‐invasive, precise spatiotemporal modulation of intracellular Wnt/β‐catenin signaling. Functionalized magnetic nanoparticles (MNPs@E/EC15) target cellular E‐cadherins to generate localized magnetomechanical forces under low‐intensity magnetic fields.
Christian Castro‐Hinojosa, Pablo Martínez‐Vicente, Lucía G. Recaredo, Susel Del Sol‐Fernández, Pilar Gomollón‐Zueco, Yilian Fernández‐Afonso, Raluca M. Fratila, María Moros   +7 more
wiley   +1 more source