Results 71 to 80 of about 315,195 (302)
Pathophysiology of the Belgrade rat [PDF]
, 2014 The Belgrade rat is an animal model of divalent metal transporter 1 (DMT1) deficiency. This strain originates from an X-irradiation experiment first reported in 1966.
Abboud +124 more
core +3 more sources
FEBS Open Bio, EarlyView.5‐Aminolevulinic acid combined with ferric ammonium citrate (5‐ALA/FAC) stimulates dermal papilla cell activity and promotes hair follicle growth. The treatment enhances ERK and AKT signaling, increases hair‐inductive gene expression, and restores dermal papilla function suppressed by dihydrotestosterone and oxidative stress, resulting in enhanced hair
Han‐Wook Ryu, Eok‐Soo Oh, Sewoon Kim
wiley +1 more source
Applied and Environmental MicrobiologyIron is a vital cofactor for enzymes essential to many biological processes, yet in excess, it poses a danger to all living organisms. In order to ensure survival and proliferation under fluctuating environmental iron levels, bacteria evolve ...
Kaiyue Jie +5 more
doaj +1 more source
Lactoferrin prevents LPS-induced decrease of the iron exporter ferroportin in human monocytes/macrophages. [PDF]
, 2014 Iron balance is tightly linked to inflammation and it has been demonstrated that many proteins involved in cellular iron management are up- or down-regulated by inflammatory stimuli, ultimately leading to iron retention in the reticuloendothelial system.
Alessandra Frioni +27 more
core +1 more source
FEBS Open Bio, EarlyView.This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia +3 more
wiley +1 more source
Biomedical Papers, 2016 Background and Aims: Erythropoiesis is closely related to iron metabolism in a balanced homeostasis. Analyses of diverse erythroid and iron metabolism disorders have shown that disrupted erythropoiesis negatively affects iron homeostasis and vice versa ...
Lucie Sulovska +8 more
doaj +1 more source
Synovial tissue macrophages: friend or foe? [PDF]
, 2017 Healthy synovial tissue includes a lining layer of synovial fibroblasts and macrophages. The influx of leucocytes during active rheumatoid arthritis (RA) includes monocytes that differentiate locally into proinflammatory macrophages, and these produce ...
Alivernini, Stefano +1 more
core +2 more sources
Macrophages and Systemic Iron Homeostasis [PDF]
Journal of Innate Immunity, 2012 As a principal aspect of their scavenging function, splenic and hepatic macrophages phagocytize and degrade senescent and damaged erythrocytes to recover iron, mainly for the production of hemoglobin in new erythrocytes but also for other carriers and enzymes requiring iron. Splenic red pulp macrophages are specialized for iron recycling with increased
openaire +2 more sources
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
The down-regulation of pank2 gene in zebrafish as a model of Pantothenate Kinase Associated Neurodegeneration. [PDF]
, 2016 open9siThe increased iron deposition is a hallmark of many neurodegenerative diseases, but its pathogenic role is still unclear. A strong link between iron and neurodegeneration is evident in a set of heterogeneous neurological disorders, known as ...
ARGENTON, FRANCESCO +8 more
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