Results 61 to 70 of about 1,098,743 (202)

Rab1A Promotes Hepatic Steatosis by Suppressing Mitophagy via the Raf‐1/ERK1/2/PINK1 Signaling Axis

Advanced Science, EarlyView.
Why does fat accumulate in the liver? Our study reveals Rab1A as the molecular switch that silences the cell's mitochondrial cleanup crew. Turning Rab1A off reactivates mitophagy, clears excess fat, and reverses fatty liver disease in mice—offering a promising new therapeutic target for MASLD, a growing global health challenge.
Li Zhang, Jianhua Li, Huilu Zhang, Qi Qin, Yichen Huang, Xiaofan Tian, Chao Sun, Binbin Li, Zhengxin Wang, Xin Zhang   +9 more
wiley   +1 more source

Brain Iron Homeostasis: A Focus on Microglial Iron

Pharmaceuticals, 2018
Iron is an essential trace element required for important brain functions including oxidative metabolism, synaptic plasticity, myelination, and the synthesis of neurotransmitters.
Israel C. Nnah, Marianne Wessling-Resnick   +1 more
doaj   +1 more source

Mining genomes of marine cyanobacteria for elements of zinc homeostasis [PDF]

, 2012
Zinc is a recognized essential element for the majority of organisms, and is indispensable for the correct function of hundreds of enzymes and thousands of regulatory proteins.
Schmid, Ralf, A. Millard (3584540), Ksibe, Amira Z., Andrew eMillard, James P. Barnett, Amira Z. Ksibe, D. J. Scanlan (7640840), A. Z. Ksibe (7640837), David J. Scanlan, Amira eKsibe, J. P. Barnett (7640834), Barnett, James P., Ralf eSchmid, Scanlan, David J., James P. Barnett, Millard, Andrew D., Blindauer, Claudia A., James P Barnett, R. Schmid (7606553), C. A. Blindauer (7640843), Claudia Andrea Blindauer, Andrew Millard, David J Scanlan, Ralf Schmid   +23 more
core   +1 more source

Mitochondria and Neuromast Tagging With Fluorescent Gallium‐Triapine Analogues: In Cellulo MP FLIM and Zebrafish Live Imaging

Advanced Science, EarlyView.
Fluorescent BODIPY‐conjugated thiosemicarbazone ligands and their Ga(III), In(III), and Fe(III) complexes, inspired by Triapine, are developed as theranostic agents. Multiphoton FLIM and confocal microscopy in cancer cells and zebrafish reveal real‐time uptake, mitochondrial localisation, and whilst spectroscopic assays indicated preserved complex ...
Megan J. Green, Michael W. Jones, Merissa Saleem, Haobo Ge, Melita Tvardauskaite, Julia Dudzic, Fernando Cortezon‐Tamarit, Rory L. Arrowsmith, Charareh Pourzand, Gabriele Kociock‐Kohn, Nicholas H. Rees, Jonathan R. Dilworth, Stephen Faulkner, Stanley W. Botchway, David Gurevich, Sofia I. Pascu   +15 more
wiley   +1 more source

P1491: THE DYNAMIC INTERACTION BETWEEN INFLAMMATION AND THE IRON SENSOR HFE, IN SEVERE MALARIA-INDUCED ANEMIA

HemaSphere, 2023
Ana Pêgo, Illyane Lima, Maja Spasic, Antonella Nai, Laura Silvestri, Raffaella Gozzelino   +5 more
doaj   +1 more source

ABOUT THE OPPORTUNITIES TO Influence MICROORGANISMS ON THE IRON HOMEOSTASIS IN THE HOST ORGANISM (Literature review)

Acta Biomedica Scientifica, 2014
Iron homeostasis, aimed at depriving the pathogen of available iron, takes an important role in protecting human body against pathogens. When infection occurs, microorganisms must overcome iron deficiency in a host organism.
V. V. Leonov, N. A. Kurlovich, L. V. Leonova, N. M. Fateeva   +3 more
doaj  

The critical role of iron homeostasis in neurodegenerative diseases

Neural Regeneration Research
Neurodegenerative diseases are prevalent conditions that greatly impact human health. These diseases are primarily characterized by the progressive loss and eventual death of neuronal function, although the precise mechanisms underlying these processes ...
Tiantian Liang, Jiasen Xu, Yan Zhu, He Zhao, Xiaoyu Zhai, Qi Wang, Xiaohui Ma, Limei Cui, Yan Sun   +8 more
doaj   +1 more source

Single‐Cell Dissection of Therapy‐Induced Remodeling Uncovers a Fibroblast‐Driven Immunosuppressive Niche and Targetable Vulnerabilities in Lethal Prostate Cancer

Advanced Science, EarlyView.
Single‐cell longitudinal profiling reveals that androgen‐deprivation therapy induces a DPT+ fibroblast‐complement axis that suppresses macrophage inflammation and drives CD8+ T cell exhaustion in prostate cancer. Concurrently, resistant epithelial subpopulations persist and engage TSPAN1‐ and NRXN1‐mediated programs promoting CRPC and neuroendocrine ...
Yang Chen, Dandan Dong, Jinling Liao, Naikai Liao, Mengqi Liu, Qin Zhang, Siting Chen, Qi Liu, Ying Lu, Tianyu Li, Chunlin Zou, Qiong Song, Qiuyan Wang, Jian Liang, Qiji Xie, Chengyang Li, Mengyun Wang, Jiwen Cheng, Zengnan Mo, Gong‐Hong Wei   +19 more
wiley   +1 more source

P1597: THE DYNAMIC INTERACTION BETWEEN INFLAMMATION AND IRON SENSORS IN MALARIA-INDUCED ANEMIA

HemaSphere, 2022
A. Pêgo, I. Lima, G. Martins, M. Vujic, A. Nai, L. Silvestri, R. Gozzelino   +6 more
doaj   +1 more source

Correction of the iron overload defect in beta-2-microglobulin knockout mice by lactoferrin abolishes their increased susceptibility to tuberculosis. [PDF]

, 2002
As a resident of early endosomal phagosomes, Mycobacterium tuberculosis is connected to the iron uptake system of the host macrophage. beta-2-microglobulin (beta2m) knockout (KO) mice are more susceptible to tuberculosis than wild-type mice, which is ...
Friedrich Priem, Priem, F, Kaufmann, Stefan HE, Collins, Helen L, Ulrich E. Schaible, Kaufmann, S H E, Schaible, Ulrich E, Helen L. Collins, Collins, H L, Priem, Friedrich, Stefan H.E. Kaufmann, Schaible, U E   +11 more
core   +1 more source