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The Role of the Liver in Iron Homeostasis and What Goes Wrong?
Journal of Renal and Hepatic Disorders, 2021 Iron is an essential mineral that is vital for growth development, normal cellular function, synthesis of hormones and connective tissue, and most importantly, serves as a component of hemoglobin to carry oxygen to body tissues. The body finely regulates
Ernesto Robalino Gonzaga +4 more
doaj +1 more source
Protein degradation and iron homeostasis
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012 Regulation of both systemic and cellular iron homeostasis requires the capacity to sense iron levels and appropriately modify the expression of iron metabolism genes. These responses are coordinated through the efforts of several key regulatory factors including F-box and Leucine-rich Repeat Protein 5 (FBXL5), Iron Regulatory Proteins (IRPs), Hypoxia ...
Thompson, Joel W., Bruick, Richard K.
openaire +2 more sources
Normal systemic iron homeostasis in mice with macrophage-specific deletion of transferrin receptor 2
, 2016 Iron is an essential element, since it is a component of many macromolecules involved in diverse physiological and cellular functions, including oxygen transport, cellular growth, and metabolism.
Secondes, Eriza S. +7 more
core +1 more source
FEBS Open Bio, EarlyView.The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley +1 more source
NCOA4 maintains murine erythropoiesis via cell autonomous and non-autonomous mechanisms
Haematologica, 2019 Ncoa4 mediates autophagic degradation of ferritin, the cytosolic iron storage complex, to maintain intracellular iron homeostasis. Recent evidence also supports a role for Ncoa4 in systemic iron homeostasis and erythropoiesis.
Naiara Santana-Codina +11 more
doaj +1 more source
Regulation of hepcidin and hemojuvelin expression and their role in iron homeostasis [PDF]
, 2010 Hepcidin is the key regulator of iron homeostasis acting as a negative regulator of intestinal iron absorption. Several proteins have recently been identified to act as upstream regulators of hepcidin expression, such as HFE and hemojuvelin (HJV ...
Salama, M.F.I.
core
FEBS Open Bio, EarlyView.Lactoferrin promotes wound healing by activating MAPK, PI3K/Akt, and extracellular matrix pathways, enhancing fibroblast remodeling, proliferation, and re‐epithelialization. These mechanisms highlight its therapeutic potential in inflammation control, tissue repair, and remodeling.
Morgana Lüdtke Azevedo +4 more
wiley +1 more source
Cellular iron homeostasis : an overview
, 2012 Cellular iron homeostasis : an overview.
Briat, Jean-Francois
core +2 more sources
FEBS Open Bio, EarlyView.NMR metabolomics revealed concentration‐dependent metabolic perturbations in HepG2 cells exposed to H2O2. Rifampicin pretreatment enhanced metabolic competence, attenuated toxin‐induced alterations and produced metabolite profiles more consistent with human liver physiology, supporting the use of CYP450‐induced HepG2 models for improved in vitro ...
Maren Jinks +4 more
wiley +1 more source
Deregulated High Affinity Copper Transport Alters Iron Homeostasis in Arabidopsis
Frontiers in Plant Science, 2020 The present work describes the effects on iron homeostasis when copper transport was deregulated in Arabidopsis thaliana by overexpressing high affinity copper transporters COPT1 and COPT3 (COPTOE).
Ana Perea-García +5 more
doaj +1 more source