Results 81 to 90 of about 1,598,338 (286)

Duodenal Lamina Propria Transferrin—A New Player in the Mucosal Block of Dietary Iron Absorption? [PDF]

Indian Journal of Medical Biochemistry
Iron is an essential trace element, and its homeostasis is subjected to strict regulatory mechanisms. Hepcidin, a liver synthesized antimicrobial peptide, is the master regulator of systemic iron homeostasis.
Jagadish Ramasamy
doaj   +1 more source

Macrophages and Systemic Iron Homeostasis [PDF]

Journal of Innate Immunity, 2012
As a principal aspect of their scavenging function, splenic and hepatic macrophages phagocytize and degrade senescent and damaged erythrocytes to recover iron, mainly for the production of hemoglobin in new erythrocytes but also for other carriers and enzymes requiring iron. Splenic red pulp macrophages are specialized for iron recycling with increased
openaire   +2 more sources

Magnetoactive Hydrogels to Probe Curvature‐Directed Endothelial Cell Mechanosensing

Advanced Healthcare Materials, EarlyView.
This work establishes a platform to investigate local curvature as a regulator of endothelial mechanosensing independent of shear stress. Magnetoactive hydrogels enable on‐demand curvature of endothelial monolayers to reproduce tortuosity quantified by clinically established metrics.
Avinava Roy, Grace K. Hinds, Joshua Yu‐Chung Liu, Ziqian Yang, Rishab Yanala, Arina E. Velieva, Claudia Loebel   +6 more
wiley   +1 more source

Iron homeostasis in the Rhodobacter genus [PDF]

, 2013
Metals are utilized for a variety of critical cellular functions and are essential for survival. However cells are faced with the conundrum of needing metals coupled with e fact that some metals, iron in particular are toxic if present in excess. Maintaining metal homeostasis is therefore of critical importance to cells.
Sébastien, Zappa, Carl E, Bauer
openaire   +2 more sources

mTOR Regulates Cellular Iron Homeostasis through Tristetraprolin

, 2012
SummaryIron is an essential cofactor with unique redox properties. Iron-regulatory proteins 1 and 2 (IRP1/2) have been established as important regulators of cellular iron homeostasis, but little is known about the role of other pathways in this process.
Blackshear, Perry J., Bayeva, Marina, Patial, Sonika, Chang, Hsiang-Chun, Ardehali, Hossein, Khechaduri, Arineh, Puig, Sergi   +6 more
core   +1 more source

A Critical Call for Mechanistic Investigations of Metal‐Bacteria Interactions

Advanced Materials, EarlyView.
It is well established that the antibacterial properties of metals have tremendous importance for bioengineering applications. What is not as appreciated, however, is the reproducibility crisis in this field's vast literature. In this perspective, we highlight this reproducibility problem, discuss its sources, and suggest solutions towards focused ...
J. Rackwitz, A. Bandyopadhyay, S. Belkin, S. Bose, N. Eliaz, J. L. Gilbert, T. C. Lowe, F. Mücklich, R. J. Turner, C. C. Tasan   +9 more
wiley   +1 more source

The liver in regulation of iron homeostasis [PDF]

American Journal of Physiology-Gastrointestinal and Liver Physiology, 2017
The liver is one of the largest and most functionally diverse organs in the human body. In addition to roles in detoxification of xenobiotics, digestion, synthesis of important plasma proteins, gluconeogenesis, lipid metabolism, and storage, the liver also plays a significant role in iron homeostasis.
Gautam Rishi, V. Nathan Subramaniam
openaire   +5 more sources

Kupffer cells modulate iron homeostasis in mice via regulation of hepcidin expression

, 2007
Hepcidin, a small cationic liver derived peptide, is a master regulator of body iron homeostasis. Cytokines and iron availability have so far been identified as regulators of hepcidin expression.
Hochegger, Kathrin, Theurl, Milan, Theurl, Igor, Schuemann, K., Subramaniam, Nathan, van Rooijen, Nico, Hochegger, K., van Rooijen, N., Weiss, Guenter, Theurl, I., Theurl, M., Subramaniam, N., Obrist, P., Schuemann, Klaus, Weiss, G., Obrist, Peter, Subramaniam, V.N.   +16 more
core   +1 more source

GaSex Nanoparticles Modulate Neutrophil Function and Mitigate NET‐Driven Osteogenic Impairment in Osteomyelitis Therapy

Advanced Materials, EarlyView.
Neutrophil extracellular traps (NETs) emerge as a critical repair‐limiting factor in osteomyelitis, driving osteoblast mitochondrial dysfunction and excessive PINK1/Parkin‐mediated mitophagy. Gallium–selenium nanoparticles (GaSex) scavenge reactive oxygen species, redirect neutrophils from NETosis toward bactericidal phagocytosis, eliminate methicillin‐
Kai Ye, Xuanzhe Liu, Zifan Pei, Chenyi Jiang, Xiaofen Zhang, Lin Lin, Qihang Fang, Binyu Chen, Longxiang Shen, Liang Cheng, Peng Ding, Xianyou Zheng   +11 more
wiley   +1 more source

The critical role of iron homeostasis in neurodegenerative diseases

Neural Regeneration Research
Neurodegenerative diseases are prevalent conditions that greatly impact human health. These diseases are primarily characterized by the progressive loss and eventual death of neuronal function, although the precise mechanisms underlying these processes ...
Tiantian Liang, Jiasen Xu, Yan Zhu, He Zhao, Xiaoyu Zhai, Qi Wang, Xiaohui Ma, Limei Cui, Yan Sun   +8 more
doaj   +1 more source