Results 81 to 90 of about 1,098,743 (202)

Mammalian SLC39A13 promotes ER/Golgi iron transport and iron homeostasis in multiple compartments

Nature Communications
Iron is a potent biochemical, and accurate homeostatic control is orchestrated by a network of interacting players at multiple levels. Although our understanding of organismal iron homeostasis has advanced, intracellular iron homeostasis is poorly ...
Huihui Li, Yanmei Cui, Yule Hu, Mengran Zhao, Kuanyu Li, Xiaoyun Pang, Fei Sun, Bing Zhou   +7 more
doaj   +1 more source

Investigation of iron metabolism in mice expressing a mutant Menke's copper transporting ATPase (Atp7a) protein with diminished activity (Brindled; Mo (Br) (/y) ).

PLoS ONE, 2013
During iron deficiency, perturbations in copper homeostasis have frequently been documented. Previous studies in iron-deprived rats demonstrated that enterocyte and hepatic copper levels increase and a copper transporter (the Menkes Copper ATPase; Atp7a)
Sukru Gulec, James F Collins
doaj   +1 more source

Impairment of interrelated iron- and copper homeostatic mechanisms in brain contributes to the pathogenesis of neurodegenerative disorders

Frontiers in Pharmacology, 2012
Iron and copper are important co-factors for a number of enzymes in the brain, including enzymes involved in neurotransmitter synthesis and myelin formation. Both shortage and an excess of iron or copper will affect the brain.
Tina eSkjørringe, Tina eSkjørringe, Lisbeth Birk Møller, Torben eMoos   +3 more
doaj   +1 more source

Advances and Perspectives in Graphene‐Based Quantum Dots Enabled Neuromorphic Devices

Advanced Science, EarlyView.
Graphene‐based QDs are zero‐dimensional carbon nanomaterials with pronounced quantum confinement and tunable electronic structures. Herein, we summarize their synthesis strategies and functionalization methods, and highlight their functional roles and operating mechanisms in devices, as well as recent advances in neuromorphic electronics. We anticipate
Yulin Zhen, Wei Zeng, Zherui Zhao, JiYu Zhao, Ziyan Huang, Zhuo Chen, Kui Zhou, Guanglong Ding, Su‐Ting Han, Ye Zhou   +9 more
wiley   +1 more source

Acute loss of the hepatic endo-lysosomal system in vivo causes compensatory changes in iron homeostasis

Scientific Reports, 2017
Liver cells communicate with the extracellular environment to take up nutrients via endocytosis. Iron uptake is essential for metabolic activities and cell homeostasis.
Christoph Metzendorf, Anja Zeigerer, Sarah Seifert, Richard Sparla, Bahar Najafi, François Canonne-Hergaux, Marino Zerial, Martina U. Muckenthaler   +7 more
doaj   +1 more source

The regulation of iron absorption and homeostasis

, 2016
Iron is an essential element in biology, required for numerous cellular processes. Either too much or too little iron can be detrimental, and organisms have developed mechanisms for balancing iron within safe limits.
Wallace, Daniel F.
core  

New perspectives on iron uptake in eukaryotes [PDF]

, 2018
All eukaryotic organisms require iron to function. Malfunctions within iron homeostasis have a range of physiological consequences, and can lead to the development of pathological conditions that can result in an excess of non-transferrin bound iron ...
Baronian, Kim, Downard, Alison J., Rawson, Frankie J., Stolnik, Snow, Snow Stolnik, Alison J. Downard, Frankie J. Rawson, Carolyn Jovanovic, Harry G. Sherman, Kim Baronian, Jovanovic, Carolyn, Sherman, Harry G.   +11 more
core   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Deficiency of α-1-antitrypsin influences systemic iron homeostasis

, 2013
Andrew J Ghio,1 Joleen M Soukup,1 Judy H Richards,1 Bernard M Fischer,2 Judith A Voynow,2 Donald E Schmechel31US Environmental Protection Agency, Chapel Hill, NC, USA; 2Division of Pediatric Pulmonary Medicine, Department of Pediatrics,3Joseph and ...
Soukup JM, Voynow JA, Fischer BM, Richards JH, Schmechel DE, Ghio AJ   +5 more
core  

The control of iron homeostasis: microRNAS join the party

, 2011
Castoldi M, Spasic MV, Altamura S, et al. (Department of Pediatric Hematology, Oncology, and Immunology, University of Heidelberg, Heidelberg, Germany; others). The liver-specific microRNA miR-122 controls systemic iron homeostasis in mice. J Clin Invest
Wallace, Daniel F., Subramaniam, V. Nathan, Darrell H.G. Crawford, V. Nathan Subramaniam, Crawford, Darrell H.G., Daniel F. Wallace   +5 more
core   +1 more source