Results 101 to 110 of about 1,598,338 (286)
Advanced Science, EarlyView.A multifunctional HA‐conjugated nanoplatform (HA‐PGMC) integrates CuO2, glucose oxidase, and mil‐100 to enable cascade catalytic ROS generation in tumor microenvironments. This self‐supplying ROS strategy induces immunogenic cell death, reprograms “cold” tumors into “hot” ones, and synergizes with PD‐L1 blockade, achieving potent chemodynamic ...
Man Lung Lee +6 more
wiley +1 more source
In this study, the molecular mechanisms of iron transport and homeostasis regulated by the Antarctic krill-derived heptapeptide–iron (LVDDHFL–iron) complex were explored. LVDDHFL–iron significantly increased the hemoglobin, serum iron, total iron binding
Na Sun (535425) +6 more
core +4 more sources
The regulation of iron absorption and homeostasis
, 2016 Iron is an essential element in biology, required for numerous cellular processes. Either too much or too little iron can be detrimental, and organisms have developed mechanisms for balancing iron within safe limits.
Wallace, Daniel F.
core
ANTIOXIDANT TREATMENT RESCUES THE HYPERGLYCEMIC AND HYPERLIPIDEMIC EFFECTS ON PLACENTAL IRON HOMEOSTASIS [PDF]
, 2019 Objectives: We have previously demonstrated an association between gestational diabetes mellitus and dysregulated placental iron transport and regulation.
Kalakaran, Thuvaraga +4 more
core
Advanced Science, EarlyView.The present study shows that Nrf2 directly binds to the Gm26550 promoter, thereby activating Gm26550 transcription and increasing its expression. Mechanistically, Gm26550 promotes IGF1 expression by functionally antagonizing miR‐26a‐5p‐mediated repression and sequestering the RBP KHSRP, thereby enhancing hippocampal neuronal synaptic plasticity and ...
Hongfang Wang +12 more
wiley +1 more source
A double-edged sword: iron regulation in alveolar lung epithelial repair
JCI InsightThe oxygen-rich milieu of the lungs necessitates precise iron homeostasis and regulation, processes that are fundamental to pulmonary physiology but often receive limited attention.
Ugonna Mbaekwe +3 more
doaj +1 more source
Biomedical Papers, 2016 Background and Aims: Erythropoiesis is closely related to iron metabolism in a balanced homeostasis. Analyses of diverse erythroid and iron metabolism disorders have shown that disrupted erythropoiesis negatively affects iron homeostasis and vice versa ...
Lucie Sulovska +8 more
doaj +1 more source
Smart Nanotechnologies for Multimodal Neuromodulation and Brain Interfacing
Advanced Science, EarlyView.Recent advances in smart nanotechnologies are expanding the toolbox for brain interfacing, from wireless neuromodulation and high‐resolution sensing to targeted delivery within the central nervous system. By combining responsive nanomaterials with bioinspired design, these platforms enable multimodal interactions with neurons and glia, while also ...
Tommaso Curiale +6 more
wiley +1 more source
Critical role of iron in the pathogenesis of the murine gangliosidoses
Neurobiology of Disease, 2009 Neurodegeneration is a prominent feature of the gangliosidoses, a group of lysosomal storage diseases. Here we show altered iron homeostasis in mouse models of both GM1 and GM2 gangliosidoses, which are characterized by progressive depletion of iron in ...
Mylvaganam Jeyakumar +4 more
doaj +1 more source
Advanced Science, EarlyView.Using single‐cell transcriptomic and epigenomic profiling, researchers mapped microglial dysfunction across the lifespan of db/db mice. The authors uncovered a nonlinear microglial remodeling featuring early inflammatory priming, a mid‐stage transcriptional inflection, and late dysfunction.
Jizhou Zhang +6 more
wiley +1 more source