Results 121 to 130 of about 315,195 (302)

Subchronic dietary exposure of rats to cadmium alters the metabolism of metals essential to bone health [PDF]

, 2004
Cadmium (Cd) was recently identified as a risk factor for osteoporosis. Skeletal damage may be the critical effect of low-level long-term exposure to Cd in the general population exposed via food, but the mechanisms behind this are not clearly understood.
Guérin, Thierry, Kolf-Clauw, Martine, Noël, Laurent   +2 more
core   +1 more source

Bioresorbable Mo–W Electrodes: Toward an Extended Operational Lifetime Through Controlled Alloying and Oxide Coating Engineering

Advanced Materials Interfaces, EarlyView.
Bioresorbable electrochemical sensors face instability in biofluids. Although alloys can mitigate rapid in vivo dissolution, Mo–W remains underexplored for sensing. This work engineers Mo–W films with a nanocrystalline oxide coating, improving stability and enabling reliable oxygen and pH sensing for up to 10 days, highlighting their potential for ...
C. Fernandes, Filippo Franceschini, Kitty Baert, Jon Ustarroz, I. Taurino   +4 more
wiley   +1 more source

HSCB, a co-chaperone in mitochondrial iron-sulfur cluster biogenesis, is a novel candidate gene for congenital sideroblastic anemia [PDF]

, 2017
Congenital sideroblastic anemias (CSA) are inherited diseases resulting from defects in heme biosynthesis, mitochondrial iron-sulfur cluster (ISC) assembly, or mitochondrial translation.
Crispin, Andrew
core  

Transition metal ions at the crossroads of mucosal immunity and microbial pathogenesis. [PDF]

, 2014
Transition metal ions are essential micronutrients for all living organisms. In mammals, these ions are often protein-bound and sequestered within cells, limiting their availability to microbes. Moreover, in response to infection, mammalian hosts further
Diaz-Ochoa, Vladimir E, Jellbauer, Stefan, Klaus, Suzi, Raffatellu, Manuela   +3 more
core   +2 more sources

Nanozymes at the Bio‐Nano Interface: From Synthesis, Defect Engineering, Catalytic Behavior in Biological Microenvironments, and Biosafety Implications

Advanced Materials Interfaces, EarlyView.
Nanozymes (NZs) have emerged as versatile artificial enzymes with tunable catalytic properties driven by atomic coordination, defect engineering, and surface chemistry. This review presents a bio–nano interface framework linking synthesis strategies, structural design, and catalytic behavior within complex biological microenvironments.
Karen Guadalupe Quintero‐Garrido, Aída Jimena Velarde‐Salcedo, Alejandro López‐Amador, Noé Arjona, Citlali Uitz Toalá, Carmen Gonzalez, Beatriz Liliana España‐Sánchez   +6 more
wiley   +1 more source

Regulatory mechanisms of iron homeostasis in maize mediated by ZmFIT

Crop Journal
Regulation of iron homeostasis in maize remains unclear, despite the known roles of FER-Like Fe deficiency-induced transcription factor (FIT) in Arabidopsis and rice.
Suzhen Li, Shuai Ma, Zizhao Song, Yu Li, Xiaoqing Liu, Wenzhu Yang, Tianyu Wang, Xiaojin Zhou, Rumei Chen   +8 more
doaj   +1 more source

NCOA4-Mediated Ferritinophagy: A Potential Link to Neurodegeneration

Frontiers in Neuroscience, 2019
NCOA4 (Nuclear receptor coactivator 4) mediates the selective autophagic degradation of ferritin, the cellular cytosolic iron storage complex, thereby playing a critical role in intracellular and systemic iron homeostasis. Disruptions in iron homeostasis
Maria Quiles del Rey, Joseph D. Mancias
doaj   +1 more source

Integrated Transcriptomics Reveals Evolutionary Trajectories and Cell Density‐Dependent Mechanisms in Aldosterone‐Producing Adenomas

Advanced Science, EarlyView.
Aldosterone‐producing adenomas (APAs) develop via two distinct paths: directly from adrenal zona glomerulosa (zG) cells, or stepwise from zG cells through aldosterone‐producing micronodules (APMs) before progressing to APAs. Advanced single‐cell and spatial analyses identified distinct cell states linked to oxidative stress and cell–cell interactions ...
Zhuolun Sun, Changying Jing, Martina Tetti, Siyuan Gong, Jia Wei, Yingxian Pang, Martin Reincke, Tracy Ann Williams   +7 more
wiley   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

Dysregulation of Iron Metabolism in Alzheimer's Disease, Parkinson's Disease, and Amyotrophic Lateral Sclerosis

Advances in Pharmacological Sciences, 2011
Dysregulation of iron metabolism has been observed in patients with neurodegenerative diseases (NDs). Utilization of several importers and exporters for iron transport in brain cells helps maintain iron homeostasis.
Satoru Oshiro, Masaki S. Morioka, Masataka Kikuchi   +2 more
doaj   +1 more source