Results 1 to 10 of about 623,994 (347)

Organic Cation Transporters in Human Physiology, Pharmacology, and Toxicology

International Journal of Molecular Sciences, 2020
Individual cells and epithelia control the chemical exchange with the surrounding environment by the fine-tuned expression, localization, and function of an array of transmembrane proteins that dictate the selective permeability of the lipid bilayer to ...
Sophia L. Samodelov, G. Kullak-Ublick, Z. Gai, M. Visentin   +3 more
semanticscholar   +1 more source

The mystery of the human proton-organic cation antiporter: One transport protein or many?

Pharmacology & Therapeutics, 2022
About 30% of all small molecular drugs are organic cations (OCs). If these are more or less hydrophilic, they require membrane transporters to pass through biological membranes. Here, the proton-organic cation (H+ OC) antiporter may play a physiologically most relevant role, particularly concerning passage through the blood-brain barrier.
Sachkova, Alexandra, Jensen, Ole, Dücker, Christof, Ansari, Salim, Brockmöller, Jürgen   +4 more
openaire   +3 more sources

Post-translational modification acts as a digital like switch influencing AtPIP2;1 water and cation permeability

Scientific Reports
Plant aquaporins (AQPs) were initially described as a family of membrane-localized proteins exclusively facilitating water transport. Subsequently, sub-sets of plant AQPs have exhibited diverse functionalities beyond water transport. The aquaporin AtPIP2;
Jiaen Qiu, Samantha A. McGaughey, Caitlin S. Byrt, Steve D. Tyerman   +3 more
doaj   +1 more source

Gate-keeper of ion transport—a highly conserved helix-3 tryptophan in a channelrhodopsin chimera, C1C2/ChRWR

Biophysics and Physicobiology, 2020
Microbial rhodopsin is a large family of membrane proteins having seven transmembrane helices (TM1-7) with an all-trans retinal (ATR) chromophore that is covalently bound to Lys in the TM7. The Trp residue in the middle of TM3, which is homologous to W86
Yujiro Nagasaka, Shoko Hososhima, Naoko Kubo, Takashi Nagata, Hideki Kandori, Keiichi Inoue, Hiromu Yawo   +6 more
doaj   +1 more source

Regulation of genes involved in carnitine homeostasis by PPARa across different species (rat, mouse, pig, cattle, chicken, and human) [PDF]

, 2012
Recent studies in rodents convincingly demonstrated that PPAR-alpha is a key regulator of genes involved in carnitine homeostasis, which serves as a reasonable explanation for the phenomenon that energy deprivation and fibrate treatment, both of which ...
Egeri, Leonie, Forkmann, Thomas, Gläsmer, Heide, Margraf, Jürgen, Teismann, Tobias   +4 more
core   +1 more source

Identification and evolutionary analysis of the metal‐tolerance protein family in eight Cucurbitaceae species

The Plant Genome, 2022
Metal‐tolerance proteins (MTPs) are divalent cation transporters and play fundamental roles in plant metal tolerance and ion homeostasis. Despite that, a systematic investigation of MTPs in Cucurbitacea is still lacking.
Xinchen Jiang, Junliang Yin, Lixin Wang, Keyong Xi, Xiongmeng Zhu, Gang Li, Yongxing Zhu, Yiqing Liu   +7 more
doaj   +1 more source

Impaired Retrograde Transport Due to Lack of TBC1D5 Contributes to the Trafficking Defect of Lysosomal Cathepsins in Ischemic/Hypoxic Cardiomyocytes

Frontiers in Cardiovascular Medicine, 2021
Lysosomal dysfunction has been found in many pathological conditions, and methods to improve lysosomal function have been reported to be protective against infarcted hearts.
Lin Cui, Qiong Zhang, Yao Huang, Lei Yang, Junhui Zhang, Junhui Zhang, Xupin Jiang, Xupin Jiang, Jiezhi Jia, Yanling Lv, Dongxia Zhang, Yuesheng Huang   +11 more
doaj   +1 more source

The transport activity of the human cationic amino acid transporter hCAT‐1 is downregulated by activation of protein kinase C [PDF]

British Journal of Pharmacology, 2001
The human cationic amino acid transporter hCAT‐1 contains several consensus sequences for phosphorylation by protein kinase C (PKC). This study investigates the effect of PKC activation on hCAT‐1‐mediated transport. When expressed in Xenopus laevis oocytes, hCAT‐1‐mediated L‐arginine transport was reduced to 44±3% after a 30 min treatment of the ...
P, Gräf, U, Förstermann, E I, Closs
openaire   +2 more sources

The Archaeal Na+/Ca2+ Exchanger (NCX_Mj) as a Model of Ion Transport for the Superfamily of Ca2+/CA Antiporters

Frontiers in Chemistry, 2021
The superfamily of Calcium/Cation (Ca2+/CA) antiporters extrude Ca2+ from the cytosol or subcellular compartments in exchange with Na+, K+, H+, Li+, or Mg2+ and thereby provide a key mechanism for Ca2+ signaling and ion homeostasis in biological systems ...
Daniel Khananshvili
doaj   +1 more source

Evidence for organic cation transporter-mediated metformin transport and 5′-adenosine monophosphate-activated protein kinase activation in rat skeletal muscles [PDF]

Metabolism, 2015
5'-Adenosine monophosphate-activated protein kinase (AMPK) is a key molecule of metabolic enhancement in skeletal muscle. We investigated whether metformin (MET) acts directly on skeletal muscle, is transported into skeletal muscle via organic cation transporters (OCTs), and activates AMPK.Isolated rat epitrochlearis and soleus muscles were incubated ...
Oshima, Rieko, Yamada, Mayumi, Kurogi, Eriko, Ogino, Yohei, Serizawa, Yasuhiro, Tsuda, Satoshi, Ma, Xiao, Egawa, Tatsuro, Hayashi, Tatsuya   +8 more
openaire   +2 more sources