Results 31 to 40 of about 104,138 (306)

Characterisation and validation of drug transport and GLP-1R function in primary porcine proximal tubular cells [PDF]

, 2006
Overview kidney: Kidney is, beside the liver, one of the most important organs for the elimination of waste products, toxins, drugs and their metabolites. Due to the anatomy of the kidney, ultra filtrate leaving the glomerulus passes first the proximal
Schlatter, Philipp
core   +1 more source

Mutation in an adaptor protein PDZK1 affects transport activity of organic cation transporter OCTNs and oligopeptide transporter PEPT2.

Drug metabolism and pharmacokinetics, 2006
Genetic polymorphisms in xenobiotic transporters have recently been clarified to be associated with change in drug distribution and disposition. To expand on recent identification of direct interaction and functional regulation of several transporters by a PDZ (PSD95, Dlg and ZO1) domain containing protein PDZK1, the effect of mutation in PDZK1 on ...
SUGIURA, Tomoko, KATO, Yukio, KUBO, Yoshiyuki, TSUJI, Akira   +3 more
openaire   +3 more sources

Phylogenetic Diversity and Physiological Roles of Plant Monovalent Cation/H+ Antiporters

Frontiers in Plant Science, 2020
The processes of plant nutrition, stress tolerance, plant growth, and development are strongly dependent on transport of mineral nutrients across cellular membranes. Plant membrane transporters are key components of these processes.
Stanislav V. Isayenkov, Stanislav V. Isayenkov, Siarhei A. Dabravolski, Ting Pan, Sergey Shabala, Sergey Shabala   +5 more
doaj   +1 more source

Similarities and contrasts in the structure and function of the calcium transporter ATP2A1 and the copper transporter ATP7B

Substantia, 2018
Ca2+ and Cu2+ ATPases are enzyme proteins that utilize ATP for active transport of Ca2+ or Cu2+ across intracellular or cellular membranes.1-4 These enzymes are referred to as P-type ATPases since they utilize ATP through formation of a phosphorylated ...
Giuseppe Inesi
doaj   +1 more source

An extracellular cation coordination site influences ion conduction of OsHKT2;2

BMC Plant Biology, 2019
Background HKT channels mediate sodium uniport or sodium and potassium symport in plants. Monocotyledons express a higher number of HKT proteins than dicotyledons, and it is only within this clade of HKT channels that cation symport mechanisms are found.
Janin Riedelsberger, Ariela Vergara-Jaque, Miguel Piñeros, Ingo Dreyer, Wendy González   +4 more
doaj   +1 more source

Zinc/iron-regulated transporter-like protein gene family in Theobroma cacao L: Characteristics, evolution, function and 3D structure analysis

Frontiers in Plant Science, 2023
The zinc/iron-regulated transporter-like protein (ZIP) gene family first identified in plants is highly distributed in the plant kingdom. This family has previously been reported to transport several essential and non-essential cationic elements ...
Daniel Dastan Rezabala Pacheco, Brenda Conceição Guimaraes Santana, Carlos Priminho Pirovani, Alex-Alan Furtado de Almeida   +3 more
doaj   +1 more source

An efficient strategy for small-scale screening and production of archaeal membrane transport proteins in Escherichia coli.

PLoS ONE, 2013
BackgroundMembrane proteins play a key role in many fundamental cellular processes such as transport of nutrients, sensing of environmental signals and energy transduction, and account for over 50% of all known drug targets.
Pikyee Ma, Filipa Varela, Malgorzata Magoch, Ana Rita Silva, Ana Lúcia Rosário, José Brito, Tânia Filipa Oliveira, Przemyslaw Nogly, Miguel Pessanha, Meike Stelter, Arnulf Kletzin, Peter J F Henderson, Margarida Archer   +12 more
doaj   +1 more source

The GARP Complex Is Involved in Intracellular Cholesterol Transport via Targeting NPC2 to Lysosomes

Cell Reports, 2017
Proper intracellular cholesterol trafficking is critical for cellular function. Two lysosome-resident proteins, NPC1 and NPC2, mediate the egress of low-density lipoprotein-derived cholesterol from lysosomes.
Jian Wei, Ying-Yu Zhang, Jie Luo, Ju-Qiong Wang, Yu-Xia Zhou, Hong-Hua Miao, Xiong-Jie Shi, Yu-Xiu Qu, Jie Xu, Bo-Liang Li, Bao-Liang Song   +10 more
doaj   +1 more source

Stereoselectivity in the Membrane Transport of Phenylethylamine Derivatives by Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3 [PDF]

, 2022
Stereoselectivity is well known and very pronounced in drug metabolism and receptor binding. However, much less is known about stereoselectivity in drug membrane transport. Here, we characterized the stereoselective cell uptake of chiral phenylethylamine
Rafehi, Muhammad, Muhammad Rafehi, Lukas Gebauer, Brockmöller, Jürgen, Gebauer, Lukas, Jürgen Brockmöller   +5 more
core   +1 more source

Structural and functional mapping of ion access pathways in the human K+-dependent Na+/Ca2+ exchanger NCKX2 using cysteine scanning mutagenesis, thiol-modifying reagents, and homology modelling

Channels
K+-dependent Na+/Ca2+ exchanger proteins (NCKX) are members of the CaCA superfamily with critical roles in vision, skin pigmentation, enamel formation, and neuronal functions.
Robert T. Szerencsei, Shitian Cai, Hristina R. Zhekova, Ali H. Jalloul, D. Peter Tieleman, Paul P.M. Schnetkamp   +5 more
doaj   +1 more source