Results 41 to 50 of about 104,138 (306)
Marine Drugs, 2017 This study examined the urinary excretion of tetrodotoxin (TTX) modeled in a porcine renal proximal tubule epithelial cell line, LLC-PK1. Time course profiles of TTX excretion and reabsorption across the cell monolayers at 37 °C showed that the amount of
Takuya Matsumoto +6 more
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Dynamic insertion of membrane proteins at the endoplasmic reticulum [PDF]
, 2005 Most eukaryotic membrane proteins are cotranslationally integrated into the endoplasmic reticulum membrane by the Sec61 translocation complex. They are targeted to the translocon by hydrophobic signal sequences which induce the translocation of either ...
Higy, Marie
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The transport activity of the human cationic amino acid transporter hCAT‐1 is downregulated by activation of protein kinase C [PDF]
British Journal of Pharmacology, 2001 The human cationic amino acid transporter hCAT‐1 contains several consensus sequences for phosphorylation by protein kinase C (PKC). This study investigates the effect of PKC activation on hCAT‐1‐mediated transport. When expressed in Xenopus laevis oocytes, hCAT‐1‐mediated L‐arginine transport was reduced to 44±3% after a 30 min treatment of the ...
P, Gräf, U, Förstermann, E I, Closs
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Frontiers in Plant Science, 2015 Ion transport is the fundamental factor determining salinity tolerance in plants. The Review starts from differences in ion transport between salt tolerant halophytes and salt-sensitive plants with an emphasis on transport of potassium and sodium via ...
Vadim eVolkov
doaj +1 more source
The Affinity of the Organic Cation Transporter rOCT1 Is Increased by Protein Kinase C-Dependent Phosphorylation [PDF]
Journal of the American Society of Nephrology, 2000 Abstract. Members of the organic cation transporter (OCT) family are mainly expressed in kidney, liver, intestine, and brain. The regulation of the OCT type 1 from rat (rOCT1) stably transfected in HEK293 cells was examined using a fluorimetric technique, 1-[3H]methyl-4-phenylpyridinium uptake studies, and fast-whole-cell patch-
Thomas, Mehrens +8 more
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Characterization of p28, a novel ERGIC/"cis"-Golgi protein, required for Golgi ribbon formation. pH measurements in the early secretory pathway "in vivo" [PDF]
, 2008 The secretory pathway of mammalian cells consists of several compartments. Transport between these organelles is accomplished via vesicular carriers or maturation. For non abundant proteins it is thought that transport receptors help the proteins to exit
Kögler, Eva Jutta
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Frontiers in Cell and Developmental Biology, 2019 Ciliated cells exploit a specific transport system, the intraflagellar transport (IFT) system, to ensure the traffic of molecules from the cell body to the cilium.
Francesca Finetti +2 more
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Intestinal OCTN2- and MCT1-targeted drug delivery to improve oral bioavailability
Asian Journal of Pharmaceutical Sciences, 2020 Various drug transporters are widely expressed throughout the intestine and play important roles in absorbing nutrients and drugs, thus providing high quality targets for the design of prodrugs or nanoparticles to facilitate oral drug delivery.
Gang Wang +8 more
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Scientific ReportsPlant aquaporins (AQPs) were initially described as a family of membrane-localized proteins exclusively facilitating water transport. Subsequently, sub-sets of plant AQPs have exhibited diverse functionalities beyond water transport. The aquaporin AtPIP2;
Jiaen Qiu +3 more
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The mystery of the human proton-organic cation antiporter: One transport protein or many?
Pharmacology & Therapeutics, 2022 About 30% of all small molecular drugs are organic cations (OCs). If these are more or less hydrophilic, they require membrane transporters to pass through biological membranes. Here, the proton-organic cation (H+ OC) antiporter may play a physiologically most relevant role, particularly concerning passage through the blood-brain barrier.
Sachkova, Alexandra +4 more
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