Results 1 to 10 of about 104 (101)
Frontiers in Chemistry, 2018 The molecular mechanisms of toxicity and cellular transport of anticancer metallodrugs, including platinum-based agents, have not yet been fully elucidated.
Sarah Spreckelmeyer +8 more
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Rescue of Misfolded Organic Cation Transporter 3 Variants
Cells, 2022 Organic cation transporters (OCTs) are membrane proteins that take up monoamines, cationic drugs and xenobiotics. We previously reported novel missense mutations of organic cation transporter 3 (OCT3, SLC22A3), some with drastically impacted transport ...
Thomas J. F. Angenoorth +7 more
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Kidney‐specific expression of a novel mouse organic cation transporter‐like protein [PDF]
FEBS Letters, 1997 Using the signal sequence trap method, we have cloned a novel 12‐membrane‐spanning transporter‐like protein, termed renal‐specific transporter (RST), from the mouse kidney. RST is a 553‐amino‐acid protein highly homologous to recently cloned organic cation transporters, e.g.
Mori, Kiyoshi +11 more
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Frontiers in Pharmacology, 2021 Organic Cation Transporter 1 (OCT1, gene symbol: SLC22A1) is predominately expressed in human liver, localized in the basolateral membrane of hepatocytes and facilitates the uptake of endogenous compounds (e.g.
Bastian Haberkorn +2 more
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The pharmacogenomics of lamotrigine (a literature review)
Анналы клинической и экспериментальной неврологии, 2021 Pharmacogenomics aims to optimize drug therapy with respect to genetic variations in various human genes, whose products affect drug pharmacokinetics and pharmacodynamics.
Asya M. Azhigova +2 more
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A human transporter protein that mediates the final excretion step for toxic organic cations [PDF]
Proceedings of the National Academy of Sciences, 2005 In mammals, toxic electrolytes of endogenous and exogenous origin are excreted through the urine and bile. Before excretion, these compounds cross numerous cellular membranes in a transporter-mediated manner. However, the protein transporters involved in the final excretion step are poorly understood.
Otsuka, Masato +5 more
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The Affinity of the Organic Cation Transporter rOCT1 Is Increased by Protein Kinase C-Dependent Phosphorylation [PDF]
Journal of the American Society of Nephrology, 2000 Abstract. Members of the organic cation transporter (OCT) family are mainly expressed in kidney, liver, intestine, and brain. The regulation of the OCT type 1 from rat (rOCT1) stably transfected in HEK293 cells was examined using a fluorimetric technique, 1-[3H]methyl-4-phenylpyridinium uptake studies, and fast-whole-cell patch-
Thomas, Mehrens +8 more
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The mystery of the human proton-organic cation antiporter: One transport protein or many?
Pharmacology & Therapeutics, 2022 About 30% of all small molecular drugs are organic cations (OCs). If these are more or less hydrophilic, they require membrane transporters to pass through biological membranes. Here, the proton-organic cation (H+ OC) antiporter may play a physiologically most relevant role, particularly concerning passage through the blood-brain barrier.
Sachkova, Alexandra +4 more
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Divergent Regulation of OCT and MATE Drug Transporters by Cadmium Exposure
Pharmaceutics, 2021 Coordinated transcellular transport by the uptake via organic cation transporters (OCTs) in concert with the efflux via multidrug and toxin extrusion proteins (MATEs) is an essential system for hepatic and renal drug disposition.
Hong Yang +5 more
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Intestinal OCTN2- and MCT1-targeted drug delivery to improve oral bioavailability
Asian Journal of Pharmaceutical Sciences, 2020 Various drug transporters are widely expressed throughout the intestine and play important roles in absorbing nutrients and drugs, thus providing high quality targets for the design of prodrugs or nanoparticles to facilitate oral drug delivery.
Gang Wang +8 more
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