Results 31 to 40 of about 36,235 (291)

Protein‐Protein Interactions Between Organic Anion Transporting Polypeptide 1B3 (OATP1B3) and Organic Cation Transporter 1 (OCT1)

The FASEB Journal, 2015
The two drug transporters OATP1B3 and OCT1 are expressed at the basolateral membrane of human hepatocytes. In a search for potential interacting proteins a modified yeast‐two‐hybrid screen (DUALmembrane screen) identified OCT1 as an interaction partner for OATP1B3.
Jessica Shoop, Melissa Ruggiero, Yuchen Zhang, Bruno Hagenbuch   +3 more
openaire   +1 more source

Renal secretion of hydrochlorothiazide involves organic anion transporter 1/3, organic cation transporter 2, and multidrug and toxin extrusion protein 2-K [PDF]

American Journal of Physiology-Renal Physiology, 2019
Hydrochlorothiazide (HCTZ) is the most widely used thiazide diuretic for the treatment of hypertension either alone or in combination with other antihypertensives. HCTZ is mainly cleared by the kidney via tubular secretion, but the underlying molecular mechanisms are unclear.
Jia Yin, David J. Wagner, Bhagwat Prasad, Nina Isoherranen, Kenneth E. Thummel, Joanne Wang   +5 more
openaire   +2 more sources

Atenolol Renal Secretion Is Mediated by Human Organic Cation Transporter 2 and Multidrug and Toxin Extrusion Proteins [PDF]

Drug Metabolism and Disposition, 2015
Atenolol is a β-blocker widely used in the treatment of hypertension. Atenolol is cleared predominantly by the kidney by both glomerular filtration and active secretion, but the molecular mechanisms involved in its renal secretion are unclear. Using a panel of human embryonic kidney cell lines stably expressing human organic cation transporter (hOCT) 1-
Jia, Yin, Haichuan, Duan, Yoshiyuki, Shirasaka, Bhagwat, Prasad, Joanne, Wang   +4 more
openaire   +2 more sources

Mutation in an adaptor protein PDZK1 affects transport activity of organic cation transporter OCTNs and oligopeptide transporter PEPT2.

Drug metabolism and pharmacokinetics, 2006
Genetic polymorphisms in xenobiotic transporters have recently been clarified to be associated with change in drug distribution and disposition. To expand on recent identification of direct interaction and functional regulation of several transporters by a PDZ (PSD95, Dlg and ZO1) domain containing protein PDZK1, the effect of mutation in PDZK1 on ...
SUGIURA, Tomoko, KATO, Yukio, KUBO, Yoshiyuki, TSUJI, Akira   +3 more
openaire   +3 more sources

Enantioselective Drug Recognition by Drug Transporters

Molecules, 2018
Drug transporters mediate the absorption, tissue distribution, and excretion of drugs. The cDNAs of P-glycoprotein, multidrug resistance proteins (MRPs/ABCC), breast cancer resistance protein (BCRP/ABCG2), peptide transporters (PEPTs/SLC15), proton ...
Yuichi Uwai
doaj   +1 more source

Insight into the Anticancer Activity of Copper(II) 5-Methylenetrimethylammonium-Thiosemicarbazonates and Their Interaction with Organic Cation Transporters

Biomolecules, 2020
A series of four water-soluble salicylaldehyde thiosemicarbazones with a positively charged trimethylammonium moiety ([H2LR]Cl, R = H, Me, Et, Ph) and four copper(II) complexes [Cu(HLR)Cl]Cl (1–4) were synthesised with the aim to study (i) their ...
Miljan N. M. Milunović, Oleg Palamarciuc, Angela Sirbu, Sergiu Shova, Dan Dumitrescu, Dana Dvoranová, Peter Rapta, Tatsiana V. Petrasheuskaya, Eva A. Enyedy, Gabriella Spengler, Marija Ilic, Harald H. Sitte, Gert Lubec, Vladimir B. Arion   +13 more
doaj   +1 more source

High Affinity Decynium-22 Binding to Brain Membrane Homogenates and Reduced Dorsal Camouflaging after Acute Exposure to it in Zebrafish

Frontiers in Pharmacology, 2022
Organic cation transporters (OCTs) are expressed in the mammalian brain, kidney, liver, placenta, and intestines, where they facilitate the transport of cations and other substrates between extracellular fluids and cells.
Georgianna G. Gould, Georgianna G. Gould, Priscilla A. Barba-Escobedo, Priscilla A. Barba-Escobedo, Rebecca E. Horton, Rebecca E. Horton, Lynette C. Daws, Lynette C. Daws, Lynette C. Daws   +8 more
doaj   +1 more source

Renoprotective Effects of Metformin are Independent of Organic Cation Transporters 1 & 2 and AMP-activated Protein Kinase in the Kidney [PDF]

Scientific Reports, 2016
AbstractThe type-2 diabetes drug metformin has proven to have protective effects in several renal disease models. Here, we investigated the protective effects in a 3-day unilateral ureteral obstruction (3dUUO) mouse model. Compared with controls, ureteral obstructed animals displayed increased tubular damage and inflammation.
Christensen, M, Jensen, JB, Jakobsen, S, Jessen, N, Frokiaer, J, Kemp, BE, Marciszyn, AL, Li, H, Pastor-Soler, NM, Hallows, KR, Norregaard, R   +10 more
openaire   +4 more sources

Interaction of Masitinib with Organic Cation Transporters

, 2022
Tyrosine kinase inhibitors (TKI) such as Masitinib were reported to be useful as therapeutic options in malignant disorders and nonmalignant diseases, like coronavirus disease 2019 (COVID-19).
Haag, Jasmin, Giuliano Ciarimboli, Steinbüchel, Martin, Ute Neugebauer, Saliha Harrach, Bertrand, Jessica, Rita Schröter, Harrach, Saliha, Ciarimboli, Giuliano, Neugebauer, Ute, Jessica Bertrand, Schröter, Rita, Martin Steinbüchel, Jasmin Haag   +13 more
core   +1 more source

Epigenetics and stroke: role of DNA methylation and effect of aging on blood–brain barrier recovery

Fluids and Barriers of the CNS, 2023
Incomplete recovery of blood–brain barrier (BBB) function contributes to stroke outcomes. How the BBB recovers after stroke remains largely unknown. Emerging evidence suggests that epigenetic factors play a significant role in regulating post-stroke BBB ...
Chelsea M. Phillips, Svetlana M. Stamatovic, Richard F. Keep, Anuska V. Andjelkovic   +3 more
doaj   +1 more source