Atypical Substrates of the Organic Cation Transporter 1 [PDF]
Biomolecules, 2022 The human organic cation transporter 1 (OCT1) is expressed in the liver and mediates hepatocellular uptake of organic cations. However, some studies have indicated that OCT1 could transport neutral or even anionic substrates.
Kyra-Elisa Maria Redeker +4 more
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Drug-Drug Interactions at Organic Cation Transporter 1 [PDF]
Frontiers in Pharmacology, 2021 The interaction between drugs and various transporters is one of the decisive factors that affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter 1 (OCT1) is a member of the Solute Carrier 22A (SLC22A) family that plays
Shiwei Zhou +5 more
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Organic Cation Transporter 1 an Intestinal Uptake Transporter: Fact or Fiction? [PDF]
Frontiers in Pharmacology, 2021 Intestinal transporter proteins are known to affect the pharmacokinetics and in turn the efficacy and safety of many orally administered drugs in a clinically relevant manner.
Christoph Wenzel +2 more
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Structural basis of promiscuous substrate transport by Organic Cation Transporter 1 [PDF]
Nature Communications, 2023 Organic Cation Transporter 1 (OCT1) plays a crucial role in hepatic metabolism by mediating the uptake of a range of metabolites and drugs. Genetic variations can alter the efficacy and safety of compounds transported by OCT1, such as those used for ...
Yi C. Zeng +8 more
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Regulation Mechanisms of Expression and Function of Organic Cation Transporter 1 [PDF]
Frontiers in Pharmacology, 2021 The organic cation transporter 1 (OCT1) belongs together with OCT2 and OCT3 to the solute carrier family 22 (SLC22). OCTs are involved in the movement of organic cations through the plasma membrane.
Giuliano Ciarimboli
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Structural insights into human organic cation transporter 1 transport and inhibition [PDF]
Cell DiscoveryThe human organic cation transporter 1 (hOCT1), also known as SLC22A1, is integral to hepatic uptake of structurally diversified endogenous and exogenous organic cations, influencing both metabolism and drug pharmacokinetics. hOCT1 has been implicated in
Shuhao Zhang +11 more
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Role of human organic cation transporter-1 (OCT-1/SLC22A1) in modulating the response to metformin in patients with type 2 diabetes [PDF]
BMC Endocrine Disorders, 2022 Background Organic cation transporter 1 primarily governs the action of metformin in the liver. There are considerable inter-individual variations in metformin response.
Fizalah Kawoosa +8 more
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Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content. [PDF]
PLoS Biology, 2018 A constellation of metabolic disorders, including obesity, dysregulated lipids, and elevations in blood glucose levels, has been associated with cardiovascular disease and diabetes. Analysis of data from recently published genome-wide association studies
Xiaomin Liang +14 more
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Genetic polymorphisms and haplotypes of the organic cation transporter 1 gene (SLC22A1) in the Xhosa population of South Africa [PDF]
Genetics and Molecular Biology, 2014 Human organic cation transporter 1 is primarily expressed in hepatocytes and mediates the electrogenic transport of various endogenous and exogenous compounds, including clinically important drugs.
Clifford Jacobs +4 more
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Transcription factor organic cation transporter 1 (OCT-1) affects the expression of porcine Klotho (KL) gene [PDF]
PeerJ, 2016 Klotho (KL), originally discovered as an aging suppressor, is a membrane protein that shares sequence similarity with the β-glucosidase enzymes. Recent reports showed Klotho might play a role in adipocyte maturation and systemic glucose metabolism ...
Yan Li, Lei Wang, Jiawei Zhou, Fenge Li
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