Results 1 to 10 of about 5,817 (113)

Isobutyrylcarnitine as a Biomarker of OCT1 Activity and Interspecies Differences in its Membrane Transport

Frontiers in Pharmacology, 2021
Genome-wide association studies have identified an association between isobutyrylcarnitine (IBC) and organic cation transporter 1 (OCT1) genotypes. Higher IBC blood concentrations in humans with active OCT1 genotypes and experimental studies with mouse ...
Ole Jensen, Johannes Matthaei, Henry G Klemp   +2 more
exaly   +3 more sources

Influence of YES1 Kinase and Tyrosine Phosphorylation on the Activity of OCT1

Frontiers in Pharmacology, 2021
Organic cation transporter 1 (OCT1) is a transporter that regulates the hepatic uptake and subsequent elimination of diverse cationic compounds. Although OCT1 has been involved in drug-drug interactions and causes pharmacokinetic variability of many ...
Muhammad Erfan Uddin, Dominique A Garrison, Yan Jin   +2 more
exaly   +3 more sources

Expansion of Knowledge on OCT1 Variant Activity In Vitro and In Vivo Using Oct1/2−/− Mice

Frontiers in Pharmacology, 2021
The role of organic cation transporter 1 (OCT1) in humans is gaining attention as data emerges regarding its role in physiology, drug exposure, and drug response.
John T Catlow, John K Fallon, Philip C Smith   +2 more
exaly   +3 more sources

Transport of Drugs and Endogenous Compounds Mediated by Human OCT1: Studies in Single- and Double-Transfected Cell Models

Frontiers in Pharmacology, 2021
Organic Cation Transporter 1 (OCT1, gene symbol: SLC22A1) is predominately expressed in human liver, localized in the basolateral membrane of hepatocytes and facilitates the uptake of endogenous compounds (e.g.
, Jörg KÖNIG, Fromm Martin F
exaly   +3 more sources

Effects of Chronic Elevation in Plasma Membrane Cholesterol on the Function of Human Na⁺/Taurocholate Cotransporting Polypeptide (NTCP) and Organic Cation Transporter 1 (OCT1) [PDF]

Livers
Background: We have previously demonstrated that the function and expression of the Na+/taurocholate cotransporting polypeptide (NTCP) and the organic cation transporter 1 (OCT1) are affected by increasing free or unesterified cholesterol in the plasma ...
Jessica Y. Idowu, Caylie McKimens, Bruno Hagenbuch   +2 more
doaj   +2 more sources

Role of OCT1 and MAP3K5 Genetic Polymorphisms in Hydroxyurea Pharmacokinetics [PDF]

Life
Background: Hydroxyurea is approved for the treatment of paediatric and adult sickle cell disease patients. It causes the synthesis of foetal haemoglobin and decreases platelets and granulocytes, but with a high interindividual variability, requiring ...
Sarah Allegra, Giuliana Abbadessa, Francesco Chiara, Daniela Di Grazia, Cristina Mirabella, Maura Caudana, Marina Zanatta, Jenni Bertello, Vincenzo Voi, Silvia De Francia   +9 more
doaj   +2 more sources

Insights Into Genetic Variations of the OCT1 Gene in Metformin Poor Responders Among Bangladeshi Type 2 Diabetic Patients [PDF]

Advances in Pharmacological and Pharmaceutical Sciences
Metformin is the most widely prescribed drug for the treatment of Type 2 diabetes mellitus (T2DM), but its response varies from person to person. This study aims to analyze the complete mutation spectrum of the OCT1 gene in metformin poor responders and ...
Rokeya Begum, Arindita Das, Md. Jahangir Alam, Gazi Nurun Nahar Sultana   +3 more
doaj   +2 more sources

Effects of genetic polymorphisms on the OCT1 and OCT2-mediated uptake of ranitidine. [PDF]

PLoS ONE, 2017
Ranitidine (Zantac®) is a H2-receptor antagonist commonly used for the treatment of acid-related gastrointestinal diseases. Ranitidine was reported to be a substrate of the organic cation transporters OCT1 and OCT2. The hepatic transporter OCT1 is highly
Marleen Julia Meyer, Tina Seitz, Jürgen Brockmöller, Mladen Vassilev Tzvetkov   +3 more
doaj   +1 more source

Effects of Genetic Polymorphism in CYP2D6, CYP2C19, and the Organic Cation Transporter OCT1 on Amitriptyline Pharmacokinetics in Healthy Volunteers and Depressive Disorder Patients

Frontiers in Pharmacology, 2021
The tricyclic antidepressant amitriptyline is frequently prescribed but its use is limited by its narrow therapeutic range and large variation in pharmacokinetics.
Johannes Matthaei, Jürgen Brockmöller, Werner Steimer, Konstanze Pischa, Stefan Leucht, Maria Kullmann, Ole Jensen, Typhaine Ouethy, Mladen Vassilev Tzvetkov, Mladen Vassilev Tzvetkov, Muhammad Rafehi   +10 more
doaj   +1 more source

Dynamic regulation of Oct1 during mitosis by phosphorylation and ubiquitination. [PDF]

PLoS ONE, 2011
Transcription factor Oct1 regulates multiple cellular processes. It is known to be phosphorylated during the cell cycle and by stress, however the upstream kinases and downstream consequences are not well understood.
Jinsuk Kang, Ben Goodman, Yixian Zheng, Dean Tantin   +3 more
doaj   +1 more source