Results 31 to 40 of about 6,916 (201)

Interactions of antiretroviral drugs with the SLC22A1 (OCT1) drug transporter [PDF]

Frontiers in Pharmacology, 2015
The SLC22A1 influx transporter is expressed on the basolateral membrane of hepatocytes and is involved in the excretion of numerous cations. Inhibition of SLC22A1 by several antiretrovirals, such as the protease inhibitor darunavir, has not previously been determined.
Moss, Darren M., Liptrott, Neill J., Siccardi, Marco, Owen, Andrew   +3 more
openaire   +3 more sources

Substrate specificity of mitochondrial intermediate peptidase analysed by a support‐bound peptide library

FEBS Open Bio, 2015
The substrate specificity of recombinant human mitochondrial intermediate peptidase (hMIP) using a synthetic support‐bound FRET peptide library is presented.
M.F.M. Marcondes, F.M. Alves, D.M. Assis, I.Y. Hirata, L. Juliano, V. Oliveira, M.A. Juliano   +6 more
doaj   +1 more source

Drug-Drug Interactions at Organic Cation Transporter 1

Frontiers in Pharmacology, 2021
The interaction between drugs and various transporters is one of the decisive factors that affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter 1 (OCT1) is a member of the Solute Carrier 22A (SLC22A) family that plays
Shiwei Zhou, Shiwei Zhou, Shiwei Zhou, Sujuan Zeng, Yan Shu, Yan Shu   +5 more
doaj   +1 more source

Role of OCT1 in hepatocellular carcinoma.

OncoTargets and therapy, 2019
Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed cancers causing death worldwide. It is difficult to detect at an early stage and most patients with advanced HCC rarely achieve satisfying therapeutic results. Accordingly, researchers have been trying to find new biomarkers for diagnosis and new methods of treatment.
Li,Jingguo, Yang,Zhengyi, Tuo,Biguang
openaire   +3 more sources

Protein Kinase C-Independent Inhibition of Organic Cation Transporter 1 Activity by the Bisindolylmaleimide Ro 31-8220.

PLoS ONE, 2015
Ro 31-8220 is a potent protein kinase C (PKC) inhibitor belonging to the chemical class of bisindolylmaleimides (BIMs). Various PKC-independent effects of Ro 31-8220 have however been demonstrated, including inhibition of the ATP-binding cassette drug ...
Abdullah Mayati, Arnaud Bruyere, Amélie Moreau, Elodie Jouan, Claire Denizot, Yannick Parmentier, Olivier Fardel   +6 more
doaj   +1 more source

Expression status of p53 and organic cation transporter 1 is correlated with poor response to preoperative chemotherapy in esophageal squamous cell carcinoma

World Journal of Surgical Oncology, 2022
Background Esophageal squamous cell carcinoma (ESCC) is a highly malignant neoplasm. DNA-damaging drugs, such as cisplatin (CDDP) and 5-fluorouracil (5-FU), are most frequently used in preoperative chemotherapy for ESCC.
Masahiro Izutsu, Takanori Domoto, Shingo Kamoshida, Hiroyuki Ohsaki, Hiroshi Matsuoka, Yusuke Umeki, Kazuya Shiogama, Masaya Hirayama, Koichi Suda, Ichiro Uyama   +9 more
doaj   +1 more source

Loss-of-function polymorphisms in the organic cation transporter OCT1 are associated with reduced postoperative tramadol consumption.

, 2016
The organic cation transporter OCT1 (SLC22A1) mediates uptake and metabolism of the active tramadol metabolite (+)O-desmethyltramadol in the liver. In this study, the influence of OCT1 genetic polymorphisms on pharmacokinetics and analgesic efficacy of ...
Tzvetkov, Mladen Vassilev, Frank, Musshoff, Frank Stüber, Steffens, Michael, Stamer, Ulrike, Ulrike M. Stamer, Jürgen Brockmöller, Stamer, Ulrike M., Musshoff, Frank, Stüber, Frank, Mladen V. Tzvetkov, Michael Steffens, Frank Musshoff, Brockmöller, Jürgen, Tzvetkov, Mladen V   +14 more
core   +1 more source

Combined and independent effects of OCT1 and CYP2D6 on the cellular disposition of drugs

Biomedicine & Pharmacotherapy, 2023
The organic cation transporter 1 (OCT1) mediates the cell uptake and cytochrome P450 2D6 (CYP2D6) the metabolism of many cationic substrates. Activities of OCT1 and CYP2D6 are affected by enormous genetic variation and frequent drug-drug interactions.
Lukas Gebauer, Christof Dücker, Ole Jensen, Jürgen Brockmöller   +3 more
openaire   +3 more sources

OCT1-target neural gene PFN2 promotes tumor growth in androgen receptor-negative prostate cancer

Scientific Reports, 2022
Androgen and androgen receptor (AR) targeted therapies are the main treatment for most prostate cancer (PC) patients. Although AR signaling inhibitors are effective, tumors can evade this treatment by transforming to an AR-negative PC via lineage ...
Daisuke Obinata, Daigo Funakoshi, Kenichi Takayama, Makoto Hara, Birunthi Niranjan, Linda Teng, Mitchell G. Lawrence, Renea A. Taylor, Gail P. Risbridger, Yutaka Suzuki, Satoru Takahashi, Satoshi Inoue   +11 more
doaj   +1 more source

PHARMACOGENETICS OF ORGANIC CATION TRANSPORTERS

Безопасность и риск фармакотерапии, 2018
This article describes basic information about the classification, structure, substrate specificity and expression of organic cation transporters. The pharmacokinetic and pharmacogenetic aspects of transporters are discussed in more detail, as well as ...
V. A. Evteev, R. E. Kazakov, O. A. Muslimova, E. Yu. Demchenkova   +3 more
doaj   +1 more source