Results 41 to 50 of about 6,916 (201)
Pharmaceutics, 2019 We aimed to assess the potential herb–drug interactions between Korean red ginseng extract (RGE) and metformin in rats in terms of the modulation of metformin transporters, such as organic cation transporter (Oct), multiple toxin and extrusion ...
Sojeong Jin +5 more
doaj +1 more source
Acta Pharmaceutica Sinica B, 2023 Body is equipped with organic cation transporters (OCTs). These OCTs mediate drug transport and are also involved in some disease process. We aimed to investigate whether liver failure alters intestinal, hepatic and renal Oct expressions using bile duct ...
Shijin Hong +7 more
doaj +1 more source
Clinical Pharmacology &Therapeutics, EarlyView.Antibody–drug conjugates (ADCs) combine the specificity of an antibody with the potency of a cytotoxic drug. Thirteen ADCs, utilizing seven unique cytotoxic payloads and targeting 11 distinct antigens, are currently approved by the US Food and Drug Administration as of June 2025, representing a rapidly growing and highly promising class of anticancer ...
Sijie Lu +6 more
wiley +1 more source
Doxorubicin induces OCT1 recruitment to the FILIP1L promoter.
, 2013 (A) We performed chromatin immunoprecipitation assays to determine if OCT1 binds to the FILIP1L promoter and if binding is influenced by doxorubicin. U2OS cells were treated with 0 or 400 ng/ml doxorubicin for 4 hours and then harvested.
Huarui Lu (311928) +1 more
core +1 more source
The Endogenous and Exogenous Substrate Spectrum of the Human Organic Cation Transporter OCT1 – a Comprehensive Characterization [PDF]
, 2021 The organic cation transporter 1 (OCT1) is most extensively expressed in the human liver. OCT1 is involved in the hepatic uptake of several drugs and endogenous compounds, which then undergo bioactivation, recycling, metabolism, or elimination.
Jensen, Ole
core +1 more source
OCT1 Genetic Variants Influence the Pharmacokinetics of Morphine in Children [PDF]
Pharmacogenomics, 2013 Large interindividual variability in morphine disposition could contribute to unpredictable variability in morphine analgesia and adverse events. Caucasian children have more adverse effects and slower morphine clearance than African-American children.
Tsuyoshi, Fukuda +8 more
openaire +2 more sources
PLoS Biology, 2018 A constellation of metabolic disorders, including obesity, dysregulated lipids, and elevations in blood glucose levels, has been associated with cardiovascular disease and diabetes. Analysis of data from recently published genome-wide association studies
Xiaomin Liang +14 more
doaj +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend A summary of the current knowledge around membrane transporter expression in the most widely used in vitro models of human trophoblasts, including primary placental tissue, cancer cell lines and trophoblast stem cells, as well as the techniques to attempt to mimic the human placenta in vivo.
Rhiannon Pass +2 more
wiley +1 more source
Function od membrane transporter Oct1 in zebrafish embryos (Danio rerio)
, 2023 Membranski transporteri ključni su za održavanje homeostaze i normalnog metabolizma, posebice u vrijeme ranog razvoja organizma. Transporteri organskih kationa (OCT, eng. Organic Cation Transporter), pripadnici superporodice SLC (eng.
Horvat, Marina
core
Polymorphic OCT1 : a Valid Biomarker, but for which Drugs?
Pharmacogenomics, 2013 At the end of each year, it is traditional to ask what we have learned in the past year and how we will we proceed. Although we may have slightly different answers, most of us will probably agree that the increasing availability of whole-genome resequencing has changed our view of genomic diversity and will significantly change research into, and ...
Brockmoeller, Juergen +1 more
openaire +3 more sources