Results 61 to 70 of about 6,916 (201)
Sensitivity to TOP2 Targeting Chemotherapeutics Is Regulated by Oct1 and FILIP1L
PLoS ONE, 2012 Topoisomerase II (TOP2) targeting drugs like doxorubicin and etoposide are frontline chemotherapeutics for a wide variety of solid and hematological malignancies, including breast and ovarian adenocarcinomas, lung cancers, soft tissue sarcomas, leukemias and lymphomas.
Huarui Lu, Timothy C Hallstrom
openaire +4 more sources
Advanced Science, Volume 13, Issue 28, 18 May 2026.Schematic diagram of our study showing that highly expressed POU2F1 in colorectal cancer (CRC) can directly accelerate the cytosolic lactate export to decrease PPP1R11 lactylation at K59, thereby attenuating the E3 ligase enzyme activity and protein stability of PPP1R11, which inhibits the ubiquitination of MDR2 at K413 and K538 but increases the ...
Longzheng Xia +8 more
wiley +1 more source
Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1) [PDF]
, 2017 Organic cation transporter 1 (OCT1) plays a critical role in the hepatocellular uptake of structurally diverse endogenous compounds and xenobiotics.
Sook Wah Yee (259951) +8 more
core +2 more sources
Multispecific Organic Cation Transporter 1 (OCT1) from Bos taurus Has High Affinity and Slow Binding Kinetics towards Prostaglandin E2. [PDF]
PLoS ONE, 2016 Organic cation transporter 1 (OCT1, SLC22A1), like many solute carrier 22 (SLC22) family members, is important for the disposition of clinically important drugs, metabolites and signaling molecules. Several studies suggest that SLC22 family (eg.
Xiao He +3 more
doaj +1 more source
Cancer Medicine, Volume 15, Issue 5, May 2026.In patients with resectable ESCC, DNA hypomethylation driven RELB overexpression promotes resistance to perioperative immunotherapy (neoadjuvant ICIs followed by surgery and adjuvant ICIs). High RELB expression correlates with increased infiltration of mature immunoregulatory dendritic cells (mregDCs) and regulatory T cells (Tregs) in the tumor ...
Lijuan Gao, Shaobo Ke
wiley +1 more source
Phenology of migrating game birds in Italy based on citizen science data
Wildlife Biology, Volume 2026, Issue 3, May 2026.Studying the timing of the seasonal movements of migratory birds, known as migration phenology, is crucial for managing and conserving migratory bird populations. This is particularly important for migratory game bird populations in Europe because, according to the EU, migratory birds should not be hunted during their breeding season or during return ...
Susan E. McKinlay +10 more
wiley +1 more source
, 2013 dissertationFor many years the Oct1 transcription factor was though to behave as a static regulator of housekeeping genes and was constitutively bound to the octamer binding sites of its targets.
Maddox, Jessica
core
Loss of Oct1 maintains normal colon homeostasis.
, 2019 (A) Lrig1-CreERT2;Oct1fl/fl mice were treated with tamoxifen to induce the deletion of Oct1 in the Lrig1+ cells of the colon. Representative H&E and Alcian blue stained images of the distal colon, as well as IHC using Oct1 antibodies, are shown. Adjacent
Claire Bensard (6668114) +6 more
core +1 more source
Pharmaceutics, 2021 Transmembrane transport of metformin is highly controlled by transporters including organic cation transporters (OCTs), plasma membrane monoamine transporter (PMAT), and multidrug/toxin extrusions (MATEs).
Yiting Yang +5 more
doaj +1 more source
Plant, Cell &Environment, Volume 49, Issue 5, Page 2516-2530, May 2026.ABSTRACT Hydroxycinnamoyl tyramine conjugates are phenolamides produced by plants in response to pathogen attack and biotic stresses. Their proposed mechanisms of action include cytotoxicity towards pathogens, cell wall reinforcement to restrict pathogen proliferation, and signaling activity to trigger general stress responses.
Halbay Turumtay +14 more
wiley +1 more source