Rescue of Misfolded Organic Cation Transporter 3 Variants [PDF]
Cells, 2022 Organic cation transporters (OCTs) are membrane proteins that take up monoamines, cationic drugs and xenobiotics. We previously reported novel missense mutations of organic cation transporter 3 (OCT3, SLC22A3), some with drastically impacted transport ...
Thomas J. F. Angenoorth +7 more
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Atypical Substrates of the Organic Cation Transporter 1 [PDF]
Biomolecules, 2022 The human organic cation transporter 1 (OCT1) is expressed in the liver and mediates hepatocellular uptake of organic cations. However, some studies have indicated that OCT1 could transport neutral or even anionic substrates.
Kyra-Elisa Maria Redeker +4 more
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Structural basis of organic cation transporter-3 inhibition [PDF]
Nature Communications, 2022 The current work reports the structure of the human organic cation transporter 3 (OCT3 / SLC22A3) and provides the structural basis of its inhibition by two specific inhibitors, decynium-22 and corticosterone.
Basavraj Khanppnavar +16 more
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Organic cation transporter novel 1 (OCTN1): beyond an ergothioneine transporter [PDF]
Cell Communication and SignalingIn this review we comprehensively discuss organic cation transporter novel 1 (OCTN1), encoded by the SLC22A4 gene as a member in the solute carrier 22 (SLC22) family, which facilitates the cellular transport of diverse cationic and zwitterionic ...
Yumeng Guo +3 more
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Drug-Drug Interactions at Organic Cation Transporter 1 [PDF]
Frontiers in Pharmacology, 2021 The interaction between drugs and various transporters is one of the decisive factors that affect the pharmacokinetics and pharmacodynamics of drugs. The organic cation transporter 1 (OCT1) is a member of the Solute Carrier 22A (SLC22A) family that plays
Shiwei Zhou +5 more
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Organic Cation Transporter 1 an Intestinal Uptake Transporter: Fact or Fiction? [PDF]
Frontiers in Pharmacology, 2021 Intestinal transporter proteins are known to affect the pharmacokinetics and in turn the efficacy and safety of many orally administered drugs in a clinically relevant manner.
Christoph Wenzel +2 more
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Structural basis of promiscuous substrate transport by Organic Cation Transporter 1 [PDF]
Nature Communications, 2023 Organic Cation Transporter 1 (OCT1) plays a crucial role in hepatic metabolism by mediating the uptake of a range of metabolites and drugs. Genetic variations can alter the efficacy and safety of compounds transported by OCT1, such as those used for ...
Yi C. Zeng +8 more
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Expression and Function of Organic Cation Transporter 2 in Pancreas [PDF]
Frontiers in Cell and Developmental Biology, 2021 Organic cation transporters (OCT) play an important role in mediating cellular uptake of several pharmaceuticals, such as the antidiabetic drug metformin and the platinum-derived chemotherapeutics.
Sandra Schorn +6 more
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Is N1-Methylnicotinamide a Good Organic Cation Transporter 2 (OCT2) Biomarker? [PDF]
MetabolitesBackground/Objectives: The impact of potential precipitant drugs on plasma or urinary exposure of endogenous biomarkers is emerging as an alternative approach to evaluating drug–drug interaction (DDI) liability.
Anoud Sameer Ailabouni +5 more
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The Mechanotransduction Channel and Organic Cation Transporter Are Critical for Cisplatin Ototoxicity in Murine Hair Cells [PDF]
Frontiers in Molecular Neuroscience, 2022 Cisplatin is one of the most widely used chemotherapeutic drugs across the world. However, the serious ototoxic effects, leading to permanent hair cell death and hearing loss, significantly limit the utility of cisplatin.
Jinan Li +4 more
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