Results 11 to 20 of about 25,837 (279)

Identification of dequalinium as a potent inhibitor of human organic cation transporter 2 by machine learning based QSAR model [PDF]

Scientific Reports
Human organic cation transporter 2 (hOCT2/SLC22A2) is a key drug transporter that facilitates the transport of endogenous and exogenous organic cations.
Fumihiro Yamane, Kenji Ikemura, Masayoshi Kondo, Manami Ueno, Masahiro Okuda   +4 more
doaj   +3 more sources

Interactions of Organic Anion Transporters and Organic Cation Transporters With Mycotoxins

Journal of Pharmacological Sciences, 2008
Mycotoxins are secondary metabolites of moulds that which exert adverse effects in humans and animals. It is known that direct cellular toxicity is often associated with increased cellular accumulation of toxic compounds, and membrane transport may be ...
Kittipong Tachampa, Michio Takeda, Suparat Khamdang, Rie Noshiro-Kofuji, Minoru Tsuda, Surawat Jariyawat, Toshiyuki Fukutomi, Samaisukh Sophasan, Naohiko Anzai, Hitoshi Endou   +9 more
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Regulation Mechanisms of Expression and Function of Organic Cation Transporter 1 [PDF]

Frontiers in Pharmacology, 2021
The organic cation transporter 1 (OCT1) belongs together with OCT2 and OCT3 to the solute carrier family 22 (SLC22). OCTs are involved in the movement of organic cations through the plasma membrane.
Giuliano Ciarimboli
doaj   +2 more sources

Organic cation transporter-3 mediates exogenous histamine uptake by primary mast cells [PDF]

Journal of Allergy and Clinical Immunology: Global
Background: Mast cells exhibit uptake of histamine from the extracellular microenvironment, which can affect the extent of histamine release following their activation. How mast cells take up exogenous histamine, however, is not fully understood. Organic
Thuy-An Nguyen, MD, Yuki Nakamura, PhD, Kentaro Yoshimura, PhD, Hiroaki Nagatomo, PhD, Keishi Narita, PhD, Nguyen Quoc Vuong Tran, MD, PhD, Kayoko Ishimaru, MS, Yoshiaki Kobayashi, MD, Nobuhiro Nakano, PhD, Satoshi Tanaka, PhD, Yoshiaki Shinohara, MD, PhD, Atsuhito Nakao, MD, PhD   +11 more
doaj   +2 more sources

A phosphotyrosine switch regulates organic cation transporters [PDF]

Nature Communications, 2016
Organic cation transporters are important drug transporters that influence therapeutic outcomes. Here, the authors find that these transporters are regulated by tyrosine phosphorylation and propose that tyrosine kinase inhibitors can influence drug ...
Jason A. Sprowl, Su Sien Ong, Alice A. Gibson, Shuiying Hu, Guoqing Du, Wenwei Lin, Lie Li, Shashank Bharill, Rachel A. Ness, Adrian Stecula, Steven M. Offer, Robert B. Diasio, Anne T. Nies, Matthias Schwab, Guido Cavaletti, Eberhard Schlatter, Giuliano Ciarimboli, Jan H. M. Schellens, Ehud Y. Isacoff, Andrej Sali, Taosheng Chen, Sharyn D. Baker, Alex Sparreboom, Navjotsingh Pabla   +23 more
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Characterization of ligand-induced thermal stability of the human organic cation transporter 2 (OCT2) [PDF]

Frontiers in Pharmacology, 2023
Introduction: The human organic cation transporter 2 (OCT2) is involved in the transport of endogenous quaternary amines and positively charged drugs across the basolateral membrane of proximal tubular cells.
Max Maane, Fangrui Xiu, Fangrui Xiu, Peter Bellstedt, Gerd A. Kullak-Ublick, Michele Visentin   +5 more
doaj   +2 more sources

Guilty by association: direct interaction with the tetraspanin CD63 suggests a role for organic cation transporter 3 in histamine release from granulocytes [PDF]

Journal of Biomedical Science
Background The organic cation transporter 3 (OCT3) is a ubiquitous transporter that carries both endogenous and exogenous substrates, such as histamine and cisplatin.
Moritz Pernecker, Miriam Dibos, Sophie Götz, Rouvier Al-Monajjed, Vivien Barz, Christian Albiker, Rita Schröter, Ute Neugebauer, Lena Ludwig-Radtke, R. Verena Taudte, Thomas Vogl, Giuliano Ciarimboli   +11 more
doaj   +2 more sources

Structural insights into human organic cation transporter 1 transport and inhibition [PDF]

Cell Discovery
The human organic cation transporter 1 (hOCT1), also known as SLC22A1, is integral to hepatic uptake of structurally diversified endogenous and exogenous organic cations, influencing both metabolism and drug pharmacokinetics. hOCT1 has been implicated in
Shuhao Zhang, Angqi Zhu, Fang Kong, Jianan Chen, Baoliang Lan, Guodong He, Kaixuan Gao, Lili Cheng, Xiaoou Sun, Chuangye Yan, Ligong Chen, Xiangyu Liu   +11 more
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Organic cation transporter 3 on neuronal mitochondria mediates MPP+-induced mitochondrial dysfunction and neurotoxicity in a TIMM22-dependent manner [PDF]

BMC Biology
Background Mitochondria play crucial roles in cellular metabolism, and metabolite compartmentalization significantly impacts mitochondrial function and disease pathophysiology.
Ao Guan, Sida Han, Suzhen Liang, Weiwei Shen, Min Guo, Mei Cui   +5 more
doaj   +2 more sources

PHARMACOGENETICS OF ORGANIC CATION TRANSPORTERS

Безопасность и риск фармакотерапии, 2018
This article describes basic information about the classification, structure, substrate specificity and expression of organic cation transporters. The pharmacokinetic and pharmacogenetic aspects of transporters are discussed in more detail, as well as ...
V. A. Evteev, R. E. Kazakov, O. A. Muslimova, E. Yu. Demchenkova   +3 more
doaj   +3 more sources