Results 31 to 40 of about 25,837 (279)
Interaction of Masitinib with Organic Cation Transporters
International Journal of Molecular Sciences, 2022 Tyrosine kinase inhibitors (TKI) such as Masitinib were reported to be useful as therapeutic options in malignant disorders and nonmalignant diseases, like coronavirus disease 2019 (COVID-19). Most kinases must be translocated into targeted cells by the action of specific transport proteins, as they are hydrophilic and not able to cross cell membranes ...
Saliha Harrach +6 more
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Cimetidine as an Organic Cation Transporter Antagonist [PDF]
The American Journal of Pathology, 2010 This Correspondence relates to “Organic transporter 2 mediates cisplatin-induced oto- and nephrotoxicity and is a target for protective interventions” (Am J Pathol 2010, 176:1169–1180).
Hans, Ehrsson +3 more
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Prediction of human drug clearance and anticipation of clinical drug-drug interaction potential from in vitro drug transport studies [PDF]
, 2014 A major concern in drug development is the characterization of new molecular entities (NMEs) with respect to their safety and efficacy. Both factors are determined by the drug’s exposure within the body which itself is affected by drug clearance ...
Kunze, Annett
core +1 more source
Renal tubule transport of organic cations [PDF]
American Journal of Physiology-Renal Physiology, 1981 Transcellular active tubular transport of organic cations occurs in the proximal renal tubule in the direction of excretion. These organic cations may be primary, secondary, tertiary, or quaternary amines. Endogenous neurohumors such as choline and catecholamines and drugs such as morphine and tetraethylammonium are representative transportable ...
openaire +2 more sources
Analysis of carnitine and acylcaritines in biological fluids and application to a clinical study [PDF]
, 2005 Carnitine, an endogenous compound present in most mammalian tissues, is involved in the transport of activated fatty acids between cellular organelles and thus plays an important role in fatty acid metabolism and in cellular energy production ...
Vernez, Laurence
core +1 more source
Functional Analysis of Human Organic Cation Transporter OCT3 (SLC22A3) Polymorphisms
Journal of Pharmacological Sciences, 2010 We analyzed the functional properties of five single nucleotide polymorphisms (SNPs) in organic cation transporter OCT3 gene (SLC22A3) resulting in the amino acid changes with a transient expression system.
Takeshi Sakata +7 more
doaj +1 more source
Organic Cation Transporters in Health and Disease [PDF]
Pharmacological Reviews, 2020 The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN)1, OCTN2, multidrug and toxin exclusion (MATE)1, and MATE kidney-specific 2 are polyspecific transporters exhibiting broadly overlapping substrate selectivities. They transport organic cations, zwitterions, and some uncharged compounds and operate as facilitated diffusion systems ...
openaire +2 more sources
Biomedicines, 2020 Organic cation transporters (OCTs) and novel organic cation transporters (OCTNs) are responsible for drug delivery in the intestine and kidney; in the lung, OCTs mediate inhaled drugs’ transport, although their physiological role in airways remains ...
Amelia Barilli +7 more
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OCTN1: A Widely Studied but Still Enigmatic Organic Cation Transporter Linked to Human Pathology and Drug Interactions. [PDF]
Int J Mol Sci, 2022 The Novel Organic Cation Transporter, OCTN1, is the first member of the OCTN subfamily; it belongs to the wider Solute Carrier family SLC22, which counts many members including cation and anion organic transporters.
Pochini L +5 more
europepmc +2 more sources
Frontiers in Pharmacology, 2021 Psychostimulants are used therapeutically and for illegal recreational purposes. Many of these are inhibitors of the presynaptic noradrenaline, dopamine, and serotonin transporters (NET, DAT, and SERT). According to their physicochemical properties, some
Ole Jensen +3 more
doaj +1 more source