Results 51 to 60 of about 25,837 (279)

General Overview of Organic Cation Transporters in Brain [PDF]

, 2021
AbstractInhibitors of Na+/Cl−dependent high affinity transporters for norepinephrine (NE), serotonin (5-HT), and/or dopamine (DA) represent frequently used drugs for treatment of psychological disorders such as depression, anxiety, obsessive-compulsive disorder, attention deficit hyperactivity disorder, and addiction. These transporters remove NE, 5-HT,
openaire   +2 more sources

Kidney-specific expression of a novel mouse organic cation transporter-like protein

, 1997
Using the signal sequence trap method, we have cloned a novel 12-membrane-spanning transporter-like protein, termed renal-specific transporter (RST), from the mouse kidney.
Ken Ebihara, Yoshihiro Ogawa, Aoki, Tomohiro, Ogawa, Yoshihiro, Kiyoshi Mori, Tomohiro Aoki, Sugawara, Akira, Nakao, Kazuwa, Takashi Kuwahara, Issei Tanaka, Akira Sugawara, Mukoyama, Masashi, Shoichi Ozaki, Tashiro, Kei, Kuwahara, Takashi, Ozaki, Shoichi, Kazuwa Nakao, Ebihara, Ken, Tanaka, Issei, Naohisa Tamura, Kei Tashiro, Tamura, Naohisa, Masashi Mukoyama, Mori, Kiyoshi   +23 more
core   +1 more source

OMaraLab/OCT1_2023: Structural Basis of Promiscuous Substrate Transport in Organic Cation Transporter 1 - MD DATA

, 2023
<p>Molecular dynamics trajectory data relating to <strong>Structural Basis of Promiscuous Substrate Transport in Organic Cation Transporter 1</strong>, by Yi C. Zeng, Meghna Sobti, Ada Quinn, Nicola J. Smith, Simon H. J. Brown, Jamie I.
Ryan, Renae M., Vandenberg, Jamie, Zeng, Yi C., Quinn, Ada, Stewart, Alastair G., Sobti, Meghna, Smith, Nicola J., O'Mara, Megan L., Brown, Simon H. J.   +8 more
core   +1 more source

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Biological Distribution of Orally Administered [¹²³I]MIBG for Estimating Gastrointestinal Tract Absorption

Pharmaceutics, 2021
Gastrointestinal tract absorption of cationic anticancer drugs and medicines was estimated using whole-body imaging following oral [123I]MIBG administration.
Masato Kobayashi, Asuka Mizutani, Yuka Muranaka, Kodai Nishi, Hisakazu Komori, Ryuichi Nishii, Naoto Shikano, Takeo Nakanishi, Ikumi Tamai, Keiichi Kawai   +9 more
doaj   +1 more source

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations [PDF]

International Journal of Molecular Sciences, 2021
This editorial summarizes the 13 scientific papers published in the Special Issue “Physiology, Biochemistry, and Pharmacology of Transporters for Organic Cations” of the International Journal of Molecular Sciences [...]
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O envolvimento dos transportadores de monoaminas na captação de serotonina em veias [PDF]

, 2012
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaA serotonina (5-HT) é um neurotransmissor que está amplamente distribuído nos principais sistemas fisiológicos e ...
De Prá, Manuel Adalberto Alfaro
core  

Nilotinib concentration in cell lines and primary CD34+ chronic myeloid leukemia cells is not mediated by active uptake or efflux by major drug transporters [PDF]

, 2009
Imatinib mesylate and nilotinib are highly effective at eradicating the majority of chronic myeloid leukemia (CML) cells; however, neither agent induces apoptosis of primitive CML CD34⁺ cells.
Holyoake, T.L., Davies, A., Jordanides, N.E., Giannoudis, A., Jorgensen, H.G., Harris, R.J., Hatziieremia, S., Mountford, J.C., Pirmohamed, M., Clark, R.E., Lucas, C.M.   +10 more
core   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source