Results 21 to 30 of about 25,837 (279)

Inhibition of the Hepatic Uptake of ^99mTc-Tetrofosmin Using an Organic Cation Transporter Blocker [PDF]

Pharmaceutics, 2021
The accumulation of high levels of 99mTc-tetrofosmin (99mTc-TF) in the hepatobiliary system can lead to imaging artifacts and interference with diagnosis.
Kodai Nishi, Masato Kobayashi, Minori Kikuchi, Asuka Mizutani, Yuka Muranaka, Ikumi Tamai, Keiichi Kawai, Takashi Kudo   +7 more
doaj   +2 more sources

Mechanisms of Sorafenib Resistance in HCC Culture Relate to the Impaired Membrane Expression of Organic Cation Transporter 1 (OCT1) [PDF]

Journal of Hepatocellular Carcinoma
Srinivas Chava,1 Nergiz Ekmen,2 Pauline Ferraris,1 Yucel Aydin,2 Krzysztof Moroz,1 Tong Wu,1 Swan N Thung,3 Srikanta Dash1,2,4 1Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA; 2Department ...
Chava S, Ekmen N, Ferraris P, Aydin Y, Moroz K, Wu T, Thung SN, Dash S   +7 more
doaj   +2 more sources

Altered cisplatin pharmacokinetics during nonalcoholic steatohepatitis contributes to reduced nephrotoxicity

Acta Pharmaceutica Sinica B, 2021
Disease-mediated alterations to drug disposition constitute a significant source of adverse drug reactions. Cisplatin (CDDP) elicits nephrotoxicity due to exposure in proximal tubule cells during renal secretion.
Joseph L. Jilek, Kayla L. Frost, Kevyn A. Jacobus, Wenxi He, Erica L. Toth, Michael Goedken, Nathan J. Cherrington   +6 more
doaj   +1 more source

Intestinal OCTN2- and MCT1-targeted drug delivery to improve oral bioavailability

Asian Journal of Pharmaceutical Sciences, 2020
Various drug transporters are widely expressed throughout the intestine and play important roles in absorbing nutrients and drugs, thus providing high quality targets for the design of prodrugs or nanoparticles to facilitate oral drug delivery.
Gang Wang, Lichun Zhao, Qikun jiang, Yixin Sun, Dongyang Zhao, Mengchi Sun, Zhonggui He, Jin sun, Yang Wang   +8 more
doaj   +1 more source

Interaction of Organic Cations with Organic Anion Transporters [PDF]

Journal of Biological Chemistry, 2009
Studies of the organic anion transporters (Oats) have focused mainly on their interactions with organic anionic substrates. However, as suggested when Oat1 was originally identified as NKT (Lopez-Nieto, C. E., You, G., Bush, K. T., Barros, E. J., Beier, D. R., and Nigam, S. K. (1997) J. Biol. Chem.
Sun-Young, Ahn, Satish A, Eraly, Igor, Tsigelny, Sanjay K, Nigam   +3 more
openaire   +2 more sources

Genetic polymorphisms and haplotypes of the organic cation transporter 1 gene (SLC22A1) in the Xhosa population of South Africa [PDF]

Genetics and Molecular Biology, 2014
Human organic cation transporter 1 is primarily expressed in hepatocytes and mediates the electrogenic transport of various endogenous and exogenous compounds, including clinically important drugs.
Clifford Jacobs, Brendon Pearce, Mornè Du Plessis, Nisreen Hoosain, Mongi Benjeddou   +4 more
doaj   +3 more sources

Mutations in Novel Organic Cation Transporter (OCTN2), an Organic Cation/Carnitine Transporter, with Differential Effects on the Organic Cation Transport Function and the Carnitine Transport Function [PDF]

Journal of Biological Chemistry, 1999
Novel organic cation transporter (OCTN2) is an organic cation/carnitine transporter, and two missense mutations, L352R and P478L, in OCTN2 have been identified as the cause for primary carnitine deficiency. In the present study, we assessed the influence of these two mutations on the carnitine transport function and the organic cation transport ...
P, Seth, X, Wu, W, Huang, F H, Leibach, V, Ganapathy   +4 more
openaire   +2 more sources

Substrates of the Human Brain Proton-Organic Cation Antiporter and Comparison with Organic Cation Transporter 1 Activities. [PDF]

Int J Mol Sci, 2022
Many organic cations (OCs) may be transported through membranes by a genetically still uncharacterized proton-organic cation (H + OC) antiporter. Here, we characterized an extended substrate spectrum of this antiporter.
Doetsch DA, Ansari S, Jensen O, Gebauer L, Dücker C, Brockmöller J, Sachkova A.   +6 more
europepmc   +2 more sources

Functional expression of a high affinity mammalian hepatic choline/organic cation transporter1

Journal of Lipid Research, 2000
Uptake by the liver of the organic cation and essential nutrient choline is required for the hepatic synthesis of phosphatidylcholine. Uptake of other organic cations is also important for the metabolism and secretion of numerous endobiotics and drugs ...
Christian J. Sinclair, Kenneth D. Chi, Veedamali Subramanian, Kristine L. Ward, Richard M. Green   +4 more
doaj   +1 more source

Metabolic Acidosis Alters Expression of Slc22 Transporters in Mouse Kidney

Kidney & Blood Pressure Research, 2020
Introduction: The kidneys play a central role in eliminating metabolic waste products and drugs through transporter-mediated excretion along the proximal tubule.
Janine Gottier Nwafor, Marta Nowik, Naohiko Anzai, Hitoshi Endou, Carsten A. Wagner   +4 more
doaj   +1 more source