Inflammation and Organic Cation Transporters Novel (OCTNs) [PDF]
BiomoleculesInflammation is a physiological condition characterized by a complex interplay between different cells handled by metabolites and specific inflammatory-related molecules. In some pathological situations, inflammation persists underlying and worsening the
Lorena Pochini +5 more
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A phosphotyrosine switch regulates organic cation transporters [PDF]
Nature Communications, 2016 Organic cation transporters are important drug transporters that influence therapeutic outcomes. Here, the authors find that these transporters are regulated by tyrosine phosphorylation and propose that tyrosine kinase inhibitors can influence drug ...
Jason A. Sprowl +23 more
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Stereoselectivity in the Membrane Transport of Phenylethylamine Derivatives by Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3 [PDF]
Biomolecules, 2022 Stereoselectivity is well known and very pronounced in drug metabolism and receptor binding. However, much less is known about stereoselectivity in drug membrane transport. Here, we characterized the stereoselective cell uptake of chiral phenylethylamine
Lukas Gebauer +2 more
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Interaction of Masitinib with Organic Cation Transporters. [PDF]
Int J Mol Sci, 2022 Tyrosine kinase inhibitors (TKI) such as Masitinib were reported to be useful as therapeutic options in malignant disorders and nonmalignant diseases, like coronavirus disease 2019 (COVID-19). Most kinases must be translocated into targeted cells by the action of specific transport proteins, as they are hydrophilic and not able to cross cell membranes ...
Harrach S +6 more
europepmc +3 more sources
Organic Cation Transporters (OCTs) in EpiAirway™, a Cellular Model of Normal Human Bronchial Epithelium [PDF]
Biomedicines, 2020 Organic cation transporters (OCTs) and novel organic cation transporters (OCTNs) are responsible for drug delivery in the intestine and kidney; in the lung, OCTs mediate inhaled drugs’ transport, although their physiological role in airways remains ...
Amelia Barilli +7 more
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Interactions of Organic Anion Transporters and Organic Cation Transporters With Mycotoxins
Journal of Pharmacological Sciences, 2008 Mycotoxins are secondary metabolites of moulds that which exert adverse effects in humans and animals. It is known that direct cellular toxicity is often associated with increased cellular accumulation of toxic compounds, and membrane transport may be ...
Kittipong Tachampa +9 more
doaj +4 more sources
Organic Cation Transporters in Psychiatric Disorders. [PDF]
Handb Exp Pharmacol, 2021 Selective serotonin reuptake inhibitors (SSRIs) are the most commonly prescribed medications for psychiatric disorders, yet they leave the majority of patients without full symptom relief. Therefore, a major research challenge is to identify novel targets for the improved treatment of these disorders.
Daws LC.
europepmc +3 more sources
PHARMACOGENETICS OF ORGANIC CATION TRANSPORTERS
Безопасность и риск фармакотерапии, 2018 This article describes basic information about the classification, structure, substrate specificity and expression of organic cation transporters. The pharmacokinetic and pharmacogenetic aspects of transporters are discussed in more detail, as well as ...
V. A. Evteev +3 more
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Cellular Uptake of Psychostimulants – Are High- and Low-Affinity Organic Cation Transporters Drug Traffickers? [PDF]
Frontiers in Pharmacology, 2021 Psychostimulants are used therapeutically and for illegal recreational purposes. Many of these are inhibitors of the presynaptic noradrenaline, dopamine, and serotonin transporters (NET, DAT, and SERT). According to their physicochemical properties, some
Ole Jensen +3 more
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Relevance of Copper and Organic Cation Transporters in the Activity and Transport Mechanisms of an Anticancer Cyclometallated Gold(III) Compound in Comparison to Cisplatin [PDF]
Frontiers in Chemistry, 2018 The molecular mechanisms of toxicity and cellular transport of anticancer metallodrugs, including platinum-based agents, have not yet been fully elucidated.
Sarah Spreckelmeyer +8 more
doaj +2 more sources