AAPS Journal, 2014 Variations in influx transport at the blood-brain barrier might affect the concentration of psychotropic drugs at their site of action and as a consequence might alter therapy response.
Joao N. Dos Santos Pereira +8 more
semanticscholar +2 more sources
Stereoselective Inhibition of High- and Low-Affinity Organic Cation Transporters. [PDF]
Mol Pharm, 2023 Many drugs have chiral centers and are therapeutically applied as racemates. Thus, the stereoselectivity in their interactions with membrane transporters needs to be addressed. Here, we studied stereoselectivity in inhibiting organic cation transporters (
Gebauer L +3 more
europepmc +2 more sources
The Impact of Genetic Polymorphisms in Organic Cation Transporters on Renal Drug Disposition. [PDF]
Int J Mol Sci, 2020 A considerable number of drugs and/or their metabolites are excreted by the kidneys through glomerular filtration and active renal tubule secretion via transporter proteins.
Zazuli Z +5 more
europepmc +2 more sources
Expert Opinion on Drug Metabolism & Toxicology, 2021 Introduction: Organic cation transporters collectively called OCTs belong to three gene families (SLC22A1 OCT1, SLC22A2 OCT2, SLC22A3 OCT3, SLC22A4 OCTN1, SLC22A5 OCTN2, SLC29A4 PMAT, SLC47A1 MATE1, and SLC47A1 MATE2-K).
H. Koepsell
semanticscholar +1 more source
Substrate Specificity of the Organic Cation Transporters MATE1 and MATE2K and Functional Overlap with OCT1 and OCT2. [PDF]
J Med ChemThe multidrug and toxin extrusion proteins MATE1 and MATE2K may determine the pharmacokinetics and drug-drug interactions of many drugs. However, their substrate spectrum and synergy with organic cation transporters OCT1 and OCT2 remain incompletely ...
Redeker KM +4 more
europepmc +2 more sources
Uptake Transporters at the Blood–Brain Barrier and Their Role in Brain Drug Disposition
Pharmaceutics, 2023 Uptake drug transporters play a significant role in the pharmacokinetic of drugs within the brain, facilitating their entry into the central nervous system (CNS).
Md Masud Parvez +4 more
doaj +1 more source
Interaction of Organic Cations with Organic Anion Transporters [PDF]
Journal of Biological Chemistry, 2009 Studies of the organic anion transporters (Oats) have focused mainly on their interactions with organic anionic substrates. However, as suggested when Oat1 was originally identified as NKT (Lopez-Nieto, C. E., You, G., Bush, K. T., Barros, E. J., Beier, D. R., and Nigam, S. K. (1997) J. Biol. Chem.
Sun-Young, Ahn +3 more
openaire +2 more sources
Selective Inhibition on Organic Cation Transporters by Carvedilol Protects Mice from Cisplatin-Induced Nephrotoxicity. [PDF]
Pharm Res, 2018 The organic cation transporters (OCTs) and multidrug and toxin extrusions (MATEs), located in the basolateral and apical membrane of proximal tubular cells respectively, are crucial determinants of renal elimination and/or toxicity of cationic drugs such
Guo D +8 more
europepmc +2 more sources
Mutations in Novel Organic Cation Transporter (OCTN2), an Organic Cation/Carnitine Transporter, with Differential Effects on the Organic Cation Transport Function and the Carnitine Transport Function [PDF]
Journal of Biological Chemistry, 1999 Novel organic cation transporter (OCTN2) is an organic cation/carnitine transporter, and two missense mutations, L352R and P478L, in OCTN2 have been identified as the cause for primary carnitine deficiency. In the present study, we assessed the influence of these two mutations on the carnitine transport function and the organic cation transport ...
P, Seth +4 more
openaire +2 more sources
Pharmacokinetics and Toxicokinetics Roles of Membrane Transporters at Kidney Level
Journal of Pharmacy & Pharmaceutical Sciences, 2020 Transporters are large membrane proteins, which control the passage of various compounds through biological membranes. These proteins are divided into uptake and efflux transporters and play an important role in the toxicokinetics of many endobiotics and
Jéssica Veiga-Matos +2 more
doaj +1 more source