Results 11 to 20 of about 110,333 (306)
Organic Cation Transporters in Human Physiology, Pharmacology, and Toxicology. [PDF]
Int J Mol Sci, 2020 Individual cells and epithelia control the chemical exchange with the surrounding environment by the fine-tuned expression, localization, and function of an array of transmembrane proteins that dictate the selective permeability of the lipid bilayer to ...
Samodelov SL +3 more
europepmc +6 more sources
Overlap and Specificity in the Substrate Spectra of Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3. [PDF]
Int J Mol Sci, 2021 Human monoamine transporters (MATs) are cation transporters critically involved in neuronal signal transmission. While inhibitors of MATs have been intensively studied, their substrate spectra have received far less attention. Polyspecific organic cation
Gebauer L +4 more
europepmc +4 more sources
Organic Cation Transporters in the Lung-Current and Emerging (Patho)Physiological and Pharmacological Concepts. [PDF]
Int J Mol Sci, 2020 Organic cation transporters (OCT) 1, 2 and 3 and novel organic cation transporters (OCTN) 1 and 2 of the solute carrier 22 (SLC22) family are involved in the cellular transport of endogenous compounds such as neurotransmitters, l-carnitine and ...
Selo MA +3 more
europepmc +3 more sources
Several orphan solute carriers functionally identified as organic cation transporters: Substrates specificity compared with known cation transporters. [PDF]
J Biol ChemOrganic cations comprise a significant part of medically relevant drugs and endogenous substances. Such substances need organic cation transporters for efficient transfer via cell membranes. However, the membrane transporters of most natural or synthetic
Redeker KM, Brockmöller J.
europepmc +3 more sources
Organic Cation Transporters in Health and Disease [PDF]
Pharmacological Reviews, 2020 The organic cation transporters (OCTs) OCT1, OCT2, OCT3, novel OCT (OCTN)1, OCTN2, multidrug and toxin exclusion (MATE)1, and MATE kidney-specific 2 are polyspecific transporters exhibiting broadly overlapping substrate selectivities. They transport organic cations, zwitterions, and some uncharged compounds and operate as facilitated diffusion systems ...
H. Koepsell
openaire +3 more sources
Role of organic cation transporters (OCTs) in the brain
Pharmacology & Therapeutics, 2015 Organic cation transporters (OCTs) are polyspecific facilitated diffusion transporters that contribute to the absorption and clearance of various physiological compounds and xenobiotics in mammals, by mediating their vectorial transport in kidney, liver or placenta cells.
Couroussé, Thomas, Gautron, Sophie
semanticscholar +5 more sources
General Overview of Organic Cation Transporters in Brain [PDF]
Handbook of Experimental Pharmacology, 2021 AbstractInhibitors of Na+/Cl−dependent high affinity transporters for norepinephrine (NE), serotonin (5-HT), and/or dopamine (DA) represent frequently used drugs for treatment of psychological disorders such as depression, anxiety, obsessive-compulsive disorder, attention deficit hyperactivity disorder, and addiction. These transporters remove NE, 5-HT,
H. Koepsell
openaire +3 more sources
International Journal of Molecular Sciences, 2020 The information derived from next generation sequencing technology allows the identification of deregulated genes, gene mutations, epigenetic modifications, and other genomic events that are associated with a given tumor entity.
B. Edemir
semanticscholar +2 more sources
Stereoselective cell uptake of adrenergic agonists and antagonists by organic cation transporters. [PDF]
Biochemical Pharmacology, 2019 Stereoselectivity is well described for receptor binding and enzyme catalysis, but so far has only been scarcely investigated in carrier-mediated membrane transport.
Ole Jensen +3 more
semanticscholar +2 more sources
Regulation of Transporters for Organic Cations by High Glucose
International Journal of Molecular Sciences, 2023 Endogenous positively charged organic substances, including neurotransmitters and cationic uremic toxins, as well as exogenous organic cations such as the anti-diabetic medication metformin, serve as substrates for organic cation transporters (OCTs) and multidrug and toxin extrusion proteins (MATEs).
Martin Steinbüchel +5 more
openaire +3 more sources