Results 51 to 60 of about 6,916 (201)

Inhibition of the Hepatic Uptake of ^99mTc-Tetrofosmin Using an Organic Cation Transporter Blocker

Pharmaceutics, 2021
The accumulation of high levels of 99mTc-tetrofosmin (99mTc-TF) in the hepatobiliary system can lead to imaging artifacts and interference with diagnosis.
Kodai Nishi, Masato Kobayashi, Minori Kikuchi, Asuka Mizutani, Yuka Muranaka, Ikumi Tamai, Keiichi Kawai, Takashi Kudo   +7 more
doaj   +1 more source

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

British Journal of Clinical Pharmacology, Volume 92, Issue 7, Page 2349-2363, July 2026.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh, Kate Hanrott, Olof Breuer, Johan Bylund, Björn Schultze, Virginia Norris   +5 more
wiley   +1 more source

Cloning and Functional Characterization of Dog OCT1 and OCT2: Another Step in Exploring Species Differences in Organic Cation Transporters [PDF]

, 2022
OCT1 and OCT2 are polyspecific membrane transporters that are involved in hepatic and renal drug clearance in humans and mice. In this study, we cloned dog OCT1 and OCT2 and compared their function to the human and mouse orthologs.
Meyer, Marleen Julia, Falk, Simon, Tzvetkov, Mladen Vassilev, Römer, Sarah, Tacke, Sabine, Simm, Stefan, Stefan Simm, Simon Falk, Tzvetkov, Mladen V., Mladen Vassilev Tzvetkov, Sabine Tacke, Marleen Julia Meyer, Joachim Geyer, Geyer, Joachim, Prinzinger, Clarissa, Sarah Römer, Clarissa Prinzinger   +16 more
core   +1 more source

OCT1 Polyspecificity—Friend or Foe? [PDF]

Frontiers in Pharmacology, 2021
Marleen J. Meyer, Mladen V. Tzvetkov
openaire   +3 more sources

Genetic analysis of OCT1 gene polymorphisms in an Indian population

Indian Journal of Human Genetics, 2011
Genetic variants of the organic cation transporter (OCT1) gene could influence interindividual variation in clinical response to metformin therapy. The genetic basis for the single-nucleotide polymorphism (SNP) of OCT1 gene has been established in other populations, but it remains to be elucidated in the Indian population. This study is focused on OCT1
Umamaheswaran, Gurusamy, Praveen, Ramakrishnan G., Arunkumar, Annan S., Das, Ashok K., Shewade, Deepak G., Adithan, Chandrasekaran   +5 more
openaire   +3 more sources

Bioenhancer‐Driven Modulation of Membrane Dynamics Improves B‐Vitamin Uptake in Caco‐2 Cells

ChemFoodChem, Volume 2, Issue 2, June 2026.
Natural bioenhancers such as extracts from ginger, turmeric, black pepper, and spearmint increase the uptake of vitamins B1, B5, B6, and B7 in Caco‐2 cells. Micellized formulations further increase efficacy. These findings indicate that altered membrane fluidity contributes to enhanced cellular absorption, providing a new route to improve vitamin B ...
Verena Preinfalk, Bernhard Blank‐Landeshammer, Marina Bishara, Sigrid Ihninger, Katja Essl, Stefanie Atzmüller, Mara Heckmann, Marcus Iken, Mario Brameshuber, Julian Weghuber   +9 more
wiley   +1 more source

The organic cation transporter OCT1 mediates the hepatic uptake of triptans

, 2017
Migräne ist mit einer weltweiten Prävalenz von 10% eine häufige Erkrankung und führt alleine in Deutschland zu volkswirtschaftlichen Gesamtkosten von geschätzt 6,72 Mrd. Euro pro Jahr. Für die Behandlung der Migräne spielen Triptane eine entscheidende
Kuron, David
core   +1 more source

Applying molecular dynamics simulations to validate OCT1 substrates uncovers vitamin K1 as a high-affinity ligand

Frontiers in Pharmacology
OCT1 is a hepatic membrane uptake transporter of clinical importance in drug metabolism and pharmacokinetics. OCT1 exhibits broad substrate specificity, mediating uptake of diverse compounds, including the neurotransmitter serotonin and the antidiabetic ...
Elham Omer Mahgoub, Reem Ali, Ayman Samara, Dindial Ramotar   +3 more
doaj   +1 more source

Proguanil and cycloguanil are organic cation transporter and multidrug and toxin extrusion substrates

Malaria Journal, 2017
Background Malaria, HIV/AIDS, and tuberculosis endemic areas show considerable geographical overlap, leading to incidence of co-infections. This requires treatment with multiple drugs, potentially causing adverse drug–drug interactions (DDIs).
Maarten van der Velden, Albert Bilos, Jeroen J. M. W. van den Heuvel, Sanna R. Rijpma, Evelien G. E. Hurkmans, Robert W. Sauerwein, Frans G. M. Russel, Jan B. Koenderink   +7 more
doaj   +1 more source

Pharmacokinetic Drug–Drug Interaction Potential of Oral Anticancer Drugs

Clinical Pharmacology &Therapeutics, Volume 119, Issue 6, Page 1614-1627, June 2026.
Drug–drug interaction (DDI) management is critical for safe and effective use of oral anticancer drugs (OADs). Our study objectives were to (i) compile clinically relevant pharmacokinetic (PK) DDI mechanisms for OADs and (ii) assess the prevalence of PK potential DDIs (PDDIs) in patients with advanced solid cancers.
Fatimah Alhurayri, Islam R. Younis, Shadia I. Jalal, Theodore F. Logan, Rohan Maniar, Steven M. Bray, Sara K. Quinney, Zeruesenay Desta, Todd C. Skaar, James E. Tisdale, Tyler Shugg   +10 more
wiley   +1 more source