Results 81 to 90 of about 6,916 (201)
Journal of Radiation and Cancer Research, 2017 Uptake transporters are being studied for roles in the entry of therapeutic drugs into cells and thus can be exploited to improve the treatment of various diseases.
Dindial Ramotar
doaj +1 more source
Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.The acyl‐CoA synthetase long‐chain (ACSL) family consists of five members, which exhibit a synergistic effect in promoting tumour lipid metabolism for energy supply. Specifically, ACSL3 and ACSL4 have antagonistic effects on the mechanisms related to ferroptosis in tumour cells.
Haocai Li +6 more
wiley +1 more source
, 2019 Der humane organische Kationentransporter (OCT1) ist stark genetisch variabel. Genetische Polymorphismen können zu interindividuellen Unterschieden in der hepatischen Aufnahme von Medikamenten führen.
Kakkar, Sawan Kumar
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Neurogastroenterology &Motility, Volume 38, Issue 3, March 2026.Mechanisms of Acetylcholine release, including typical and atypical release under neuronal blockade. Left panel illustrates the classical (quantal) cholinergic transmission and the right panel the mechanism described in the present study. High‐Affinity Choline Transporter (HCT), Acetylcholine (ACh), Acetylcholinesterase (ACE), and Tetrodotoxin (TTX ...
A. Martinez‐Daunis +4 more
wiley +1 more source
Association of Oct1 with normal somatic stem cells.
, 2012 A. IF images of cross-sections from grossly uninvolved colon margins of a male familial adenomatous polyposis patient. Frozen sections were stained with mouse anti-Oct1 antibodies (Millipore MAB5434) and co-stained with TO-PRO.
Samuel South (120988) +11 more
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Molecular basis of polyspecific drug binding and transport by OCT1 and OCT2
, 2023 Abstract A wide range of endogenous and xenobiotic organic ions require facilitated transport systems to cross the plasma membrane for their disposition 1, 2 . In mammals, organic cation transporter subtypes 1 and 2 (OCT1 and OCT2, also known as SLC22A1 and SLC22A2, respectively ...
Yang Suo +7 more
openaire +2 more sources
Investigation of mRNA Expression Levels of TGIFLX and OCT1 Homeobox Genes in Colorectal Cancer
Acta Medica Iranica, 2019 The OCT1 and TGIFLX transcription factors are members of homeodomains whose expressions have been implicated in normal and abnormal development. However, the expression of TGIFLX and OCT1 in colorectal cancer is unknown.
Narges Sadeghipour +5 more
doaj
OCT1 (SLC22A1) transporter kinetics and regulation in primary human hepatocyte 3D spheroids
Scientific Reports3D spheroids of primary human hepatocytes (3D PHH) retain a differentiated phenotype with largely conserved metabolic function and proteomic fingerprint over weeks in culture.
Evgeniya Mickols +11 more
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Metformin‐Mediated Glycaemic Regulation as a Potential Strategy for Breast Cancer Prevention
Cancer Medicine, Volume 15, Issue 2, February 2026.Metformin (MET), a common antihyperglycemic drug, shows promising anti‐cancer effects in breast cancer (BC). It activates adenosine monophosphate‐activated protein kinase (AMPK), regulating cellular energy and inducing cell cycle arrest, anti‐proliferation, and microenvironment alterations.
Ambulugala Gamage Rajika Greshamali Jinadasa +4 more
wiley +1 more source
OCT1-mediated cellular drug uptake and interactions between drug transport and drug metabolism [PDF]
, 2012 OCT1 is a polyspecific organic cation transporter belonging to the solute carrier gene family SLC22. Human OCT1 is mainly expressed on the sinusoidal membrane of hepatocytes and thus may play an important role in the hepatocellular uptake and metabolism ...
Saadatmand, Ali Reza
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