Results 101 to 110 of about 6,916 (201)

Characterization of the world wide genetic variability of the organic cation transporter OCT1

, 2017
Der Transporter für organische Kationen OCT1 ist einer der am stärksten exprimierten Membrantransporter in der Leber und vermittelt die Aufnahme von kationischen und schwach basischen Medikamenten oder anderen Xenobiotika in die Hepatozyten. Das OCT1-Gen
Stalmann, Robert Johannes Ulrich
core   +1 more source

The Transcription Factor OCT1 in Metabolism and Malignancy

, 2018
The transition of a cell from a normal to a cancerous state requires a series of alterations within the cell that often start with genetic changes to tumor suppressors and oncogenes.
Vázquez-Arreguín, Karina
core  

OCT1 and natural metabolites interactions characterized by various studies.

, 2016
OCT1 and natural metabolites interactions characterized by various studies.
Xiao He (223527), Denisse Garza (2590957), Sanjay K. Nigam (315938), Geoffrey Chang (211406)   +3 more
core   +1 more source

Patient-derived castration-resistant prostate cancer model revealed CTBP2 upregulation mediated by OCT1 and androgen receptor

BMC Cancer
Background Prostate cancer is dependent on androgen receptor (AR) signaling, and androgen deprivation therapy (ADT) has proven effective in targeting prostate cancer. However, castration-resistant prostate cancer (CRPC) eventually emerges.
Daisuke Obinata, Kenichi Takayama, Mitchell G Lawrence, Daigo Funakoshi, Makoto Hara, Birunthi Niranjan, Linda Teng, Renea A Taylor, Gail P Risbridger, Satoru Takahashi, Satoshi Inoue   +10 more
doaj   +1 more source

The transcription factor OCT1 mediates doxorubicin induced FILIP1L expression and apoptosis.

, 2013
OCT1, also called POU2F1 (POU domain, class 2, transcription factor 1), is a transcription factor that plays a role in the DNA damage response. We identified potential OCT1 binding sites in the FILIP1L promoter and tested if OCT1 is involved in ...
Huarui Lu (311928), Timothy C. Hallstrom (311929)   +1 more
core   +1 more source

Is N1-Methylnicotinamide a Good Organic Cation Transporter 2 (OCT2) Biomarker?

Metabolites
Background/Objectives: The impact of potential precipitant drugs on plasma or urinary exposure of endogenous biomarkers is emerging as an alternative approach to evaluating drug–drug interaction (DDI) liability.
Anoud Sameer Ailabouni, Gautam Vijaywargi, Sandhya Subash, Dilip Kumar Singh, Zsuzsanna Gaborik, Bhagwat Prasad   +5 more
doaj   +1 more source

PBPK Model of Morphine Incorporating Developmental Changes in Hepatic OCT1 and UGT2B7 Proteins to Explain the Variability in Clearances in Neonates and Small Infants

CPT: Pharmacometrics & Systems Pharmacology, 2018
Morphine has large pharmacokinetic variability, which is further complicated by developmental changes in neonates and small infants. The impacts of organic cation transporter 1 (OCT1) genotype and changes in blood‐flow on morphine clearance (CL) were ...
Chie Emoto, Trevor N. Johnson, Sibylle Neuhoff, David Hahn, Alexander A. Vinks, Tsuyoshi Fukuda   +5 more
doaj   +1 more source

Assessing the Role of Incubation Temperature as a Barrier to Successful Establishment of Coho Salmon (Oncorhynchus kisutch) in a Rapidly Warming Arctic

Ecology and Evolution
Warming associated with climate change is driving poleward shifts in the marine habitat of anadromous Pacific salmon (Oncorhynchus spp.). Yet the spawning locations for salmon to establish self‐sustaining populations and the consequences for the ...
Elizabeth D. Lindley, Karen M. Dunmall, Peter A. H. Westley   +2 more
doaj   +1 more source

Liver Fibrosis Stages Affect Organic Cation Transporter 1/2 Activities in Hepatitis C Virus-Infected Patients

Pharmaceuticals
This study aims to evaluate the impact of liver fibrosis stages of chronic infection with hepatitis C virus (HCV) on the in vivo activity of organic cation transporters (hepatic OCT1 and renal OCT2) using metformin (MET) as a probe drug.
Matheus De Lucca Thomaz, Carolina Pinto Vieira, Juciene Aparecida Caris, Maria Paula Marques, Adriana Rocha, Tiago Antunes Paz, Rosamar Eulira Fontes Rezende, Vera Lucia Lanchote   +7 more
doaj   +1 more source

Effects of OCT1 polymorphisms on the cellular uptake, plasma concentrations and efficacy of the 5-HT3 antagonists tropisetron and ondansetron

, 2012
After uptake into liver cells, the antiemetic drugs tropisetron and ondansetron undergo metabolic inactivation by cytochrome P450 2D6 (CYP2D6). We investigated whether the hepatic organic cation transporter 1 (OCT1; SLC22A1) mediates cellular uptake and ...
Tzvetkov, Mladen Vassilev, Kaiser, R., Saadatmand, Ali Reza, Bokelmann, Kristin, Meineke, Ingolf, Brockmoeller, Juergen   +5 more
core   +1 more source