Results 111 to 120 of about 6,916 (201)

Determination of imatinib intracellular uptake in leukocytes as a prognostic factor in cML therapy

Zdravniški Vestnik, 2012
Background: Imatinib is the first target therapy for chronic myelogenous leukemia (CML). Response to imatinib treatment also depends on the uptake of the drug into the target cell by organic cation transporter 1 (OCT1). OCT1 activity determined by the
Eva Kralj, Simon Žakelj, Jurij Trontelj, Katja Berginc, Tadej Pajić, Irena Preložnik Zupan, Peter Černelč, Barbara Ostanek, Helena Podgornik, Janja Marc, Albin Kristl   +10 more
doaj  

Tethered-Hopping Model for Protein-DNA Binding and Unbinding Based on Sox2-Oct1-Hoxb1 Ternary Complex Simulations

, 2010
The sliding and hopping models encapsulate the essential protein-DNA binding process for binary complex formation and dissociation. However, the effects of a cofactor protein on the protein-DNA binding process that leads to the formation of a ternary ...
Lian, Peng, Angela Liu, Limin, Shi, Yongxiang, Wei, Dongqing, Bu, Yuxiang   +4 more
core   +1 more source

Global genetic analyses reveal strong inter-ethnic variability in the loss of activity of the organic cation transporter OCT1

, 2015
Background: The organic cation transporter OCT1 (SLC22A1) mediates the uptake of vitamin B1, cationic drugs, and xenobiotics into hepatocytes. Nine percent of Caucasians lack or have very low OCT1 activity due to loss-of-function polymorphisms in OCT1 ...
Nawar Dalila, Tina Seitz, Chen, Jiayin, Tzvetkov, Mladen Vassilev, Robert Stalmann, Pereira, Joao N. dos Santos, Seitz, Tina, Brockmoeller, Juergen, Pojar, Sherin, Kraetzner, Ralph, Stalmann, Robert, Jürgen Brockmöller, Jiayin Chen, Sherin Pojar, Mladen V. Tzvetkov, Joao N. Dos Santos Pereira, Ralph Krätzner, Dalila, Nawar   +17 more
core   +1 more source

Doctor of Philosophy [PDF]

, 2011
dissertationThe Oct1/POU2F1 transcription factor was previously thought to constitutively occupy its cognate DNA binding sites, and to regulate the expression of housekeeping genes.
Kang, Jinsuk
core  

OCT1 genetic variants are associated with postoperative morphine-related adverse effects in children

, 2017
Aim: Large interindividual variability in morphine pharmacokinetics (PK) could contribute to variability in morphine analgesia and adverse events. Respiratory depression (RD) and postoperative nausea and vomiting (PONV) are significant adverse drug ...
Xue Zhang, Vidya Chidambaran, Alexander A Vinks, Rajiv Balyan, Lisa J Martin, Senthilkumar Sadhasivam, Tomoyuki Mizuno, Tsuyoshi Fukuda   +7 more
core   +1 more source

Effect of SLC22A1 polymorphism on the pharmacokinetics of proguanil in Korean: A semi‐physiologic population pharmacokinetic approach

Clinical and Translational Science
Proguanil, an antimalarial drug, undergoes hepatic uptake by the polymorphic organic cation transporter 1 (OCT1) and is subsequently metabolized by the cytochrome P‐450 2C19 (CYP2C19) enzyme into its active metabolite, cycloguanil.
Juyoung Khwarg, Eunsol Yang, Chan Song Park, Sang Chun Ji, Kyung‐Sang Yu, SeungHwan Lee   +5 more
doaj   +1 more source

Helicobacter pylori SlyD stabilizes TPT1 via hnRNPK and enhances OCT1-mediated CDX2 transcriptional activation to drive gastric intestinal metaplasia

BMC Medicine
Background Gastric intestinal metaplasia (GIM) represents an important precancerous lesion in intestinal-type gastric cancer, triggered by persistent Helicobacter pylori (H. pylori) infection.
Shuwen Zheng, Yingying Wang, Chuxuan Ni, Rui Guo, Xunan Qiu, Jijun Chen, Lu Wang, Xiaohu Sun, Moye Chen, Yunen Liu, Yuan Yuan, Yuehua Gong   +11 more
doaj   +1 more source

Mechanisms of Sorafenib Resistance in HCC Culture Relate to the Impaired Membrane Expression of Organic Cation Transporter 1 (OCT1)

Journal of Hepatocellular Carcinoma
Srinivas Chava,1 Nergiz Ekmen,2 Pauline Ferraris,1 Yucel Aydin,2 Krzysztof Moroz,1 Tong Wu,1 Swan N Thung,3 Srikanta Dash1,2,4 1Department of Pathology and Laboratory Medicine, Tulane University Health Sciences Center, New Orleans, LA, USA; 2Department ...
Chava S, Ekmen N, Ferraris P, Aydin Y, Moroz K, Wu T, Thung SN, Dash S   +7 more
doaj  

Functional processing enhances hepatic targeting: the OAT2/MRP2 mechanism of vinegar-processed Cyperi Rhizoma. [PDF]

Front Nutr
Xu G, Chen Y, Jiang S, Zhang S, Ge X, Zhang F, Gao H.   +6 more
europepmc   +1 more source

Regulation of B cell development and lymphocyte function by transcriptional coactivator OCA-B. [PDF]

Front Immunol
Lu X, Roeder RG.
europepmc   +1 more source