Results 91 to 100 of about 6,916 (201)
Clinical Pharmacology in Drug Development, Volume 15, Issue 2, February 2026.Abstract Mocravimod, a novel immunomodulator targeting sphingosine‐1‐phosphate receptor (S1PR), is being developed as a maintenance treatment for patients with acute myeloid leukemia undergoing allogeneic hematopoietic cell transplantation. Preclinical data suggested that cytochrome (CYP) 3A4 is the primary enzyme involved in mocravimod metabolism.
Dymphy R. Huntjens +2 more
wiley +1 more source
IFI16 prevents Oct1 accumulation at HSV-1 promoters.
, 2014 U2OS and clone 67 cells were infected with HSV-1 at an moi of 1 pfu/cell. ChIP analysis was done with Oct1 antibody and real-time PCR with primers to the indicated HSV-1 genes, normalized to input ICP4, and cellular promoters normalized to GAPDH and are ...
Karen E. Johnson (655281) +5 more
core +1 more source
Genetic analysis of OCT1 gene polymorphisms in an Indian population
, 2012 Background: Genetic variants of the organic cation transporter (OCT1) gene could influence interindividual variation in clinical response to metformin therapy.
Praveen, Ramakrishnan G. +5 more
core +1 more source
BiomoleculesBOB1, a mammalian lymphocyte-specific transcriptional coactivator of the transcription factors OCT1 and OCT2 (OCT1/2), plays important roles in normal immune responses, autoimmunity, and hematologic malignancies.
Igor B. Nazarov +5 more
doaj +1 more source
Loss of Oct1 interferes with hematopoietic engraftment.
, 2012 A. Peripheral blood leukocyte B and T cell profiles from primary and secondary animals transplanted with Oct1 deficient and WT littermate control fetal liver (FL).
Samuel South (120988) +11 more
core +1 more source
, 2020 Thiamine is substrate of the hepatic uptake transporter organic cation transporter 1 (OCT1), and pathological lipid metabolism was associated with OCT1‐dependent thiamine transport.
Ole Jensen +11 more
core +1 more source
Oct1 function modulated thiamine disposition in vivo and in vitro.
, 2018 (A) Scheme: deletion of Oct1 reduces hepatic uptake of thiamine and increases plasma thiamine levels. (B) Plasma thiamine levels (n = 6 per genotype on a control diet; n = 7 per genotype on a TD).
Eugene C. Chen (1469383) +14 more
core +1 more source
, 2019 (A) Kaplan-Meier survival curves were downloaded and modified using OncoLnc [69] and gene symbol Pou2f1. Survival in days of human breast and colon cancer patients in whose tumors Oct1 (Pou2f1) mRNA expression falls in the bottom (“Low”) or top (“High ...
Claire Bensard (6668114) +6 more
core +1 more source
Oct1 protein levels correlate with a stem cell phenotype in primary human malignancy.
, 2012 A. IF images are shown. Frozen malignant breast carcinoma sections (non-familial stage IIIA node-positive infiltrating ductal carcinoma, ER+PR+HER2−) were stained with mouse anti-Oct1 antibodies (Millipore MAB5434) and rabbit anti-ALDH1 antibodies (Abcam
Samuel South (120988) +11 more
core +1 more source
Differential expression of several drug transporter genes in HepG2 and Huh-7 cell lines
Advanced Biomedical Research, 2016 Background: Cell culture techniques have many advantages for investigation of drug transport to target organ like liver. HepG2 and Huh-7 are two cell lines available from hepatoma that can be used as a model for hepatic drug transport.
Melva Louisa +4 more
doaj +1 more source