Results 21 to 30 of about 6,916 (201)
OCT1 – a yeast mitochondrial thiolase involved in the 3-oxoadipate pathway [PDF]
FEMS Yeast Research, 2021 ABSTRACT The 3-oxoacyl-CoA thiolases catalyze the last step of the fatty acid β-oxidation pathway. In yeasts and plants, this pathway takes place exclusively in peroxisomes, whereas in animals it occurs in both peroxisomes and mitochondria. In contrast to baker's yeast Saccharomyces cerevisiae, yeast species from the Debaryomycetaceae
Romana Vrzoňová +10 more
openaire +4 more sources
Frontiers in Pharmacology, 2021 Organic cation transporter 1 (OCT1, SLC22A1) is localized in the sinusoidal membrane of human hepatocytes and mediates hepatic uptake of weakly basic or cationic drugs and endogenous compounds. Common amino acid substitutions in OCT1 were associated with
Sarah Römer +15 more
doaj +1 more source
Human Homeobox TGIFLX Regulates CDX1, CDX2, and OCT1 Genes Expression in Colorectal Cancer Cell Lines [PDF]
Middle East Journal of Cancer, 2022 Background: Homeodomain transcriptional regulatory proteins, which are encoded by Homeobox (HOX) genes, play critical roles in both normal development and carcinogenesis.
Soroosh Shahryarhesami +3 more
doaj +1 more source
OCT1 in hepatic steatosis and thiamine disposition [PDF]
Cell Cycle, 2015 The human organic cation transporter, OCT1 (SLC22A1), a member of the SLC22 family, was first cloned in 1997.1 Since then OCT1 has been characterized as a major drug transporter in the liver, transporting important pharmacologic agents including the anti-diabetic drug, metformin and the anti-cancer drug, oxaliplatin.
Chen, Ligong +2 more
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Atypical Substrates of the Organic Cation Transporter 1
Biomolecules, 2022 The human organic cation transporter 1 (OCT1) is expressed in the liver and mediates hepatocellular uptake of organic cations. However, some studies have indicated that OCT1 could transport neutral or even anionic substrates.
Kyra-Elisa Maria Redeker +4 more
doaj +1 more source
OBF1 enhances transcriptional potential of Oct1 [PDF]
The EMBO Journal, 2003 The POU transcription factors Oct1 and Oct2 bind to DNA in various monomer and dimer configurations. Depending on the DNA sequence to which they bind, the dimers are arranged in configurations that are either accessible (PORE sequence) or inaccessible (MORE sequence) to the B-cell-specific cofactor OBF1 (OcaB, Bob1).
Katharina, Lins +6 more
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Regulation Mechanisms of Expression and Function of Organic Cation Transporter 1
Frontiers in Pharmacology, 2021 The organic cation transporter 1 (OCT1) belongs together with OCT2 and OCT3 to the solute carrier family 22 (SLC22). OCTs are involved in the movement of organic cations through the plasma membrane.
Giuliano Ciarimboli
doaj +1 more source
Structural basis of promiscuous substrate transport by Organic Cation Transporter 1
Nature Communications, 2023 Organic Cation Transporter 1 (OCT1) plays a crucial role in hepatic metabolism by mediating the uptake of a range of metabolites and drugs. Genetic variations can alter the efficacy and safety of compounds transported by OCT1, such as those used for ...
Yi C. Zeng +8 more
doaj +1 more source
, 2019 Genetic variants in the hepatic uptake transporter OCT1, observed in 9% of Europeans and white Americans, are known to affect pharmacokinetics and efficacy of tramadol, morphine, and codeine.
Mladen V. Tzvetkov (7578221) +5 more
core +3 more sources
Significance of OCT1 Expression in Acute Myeloid Leukemia
Pathology & Oncology Research, 2016 Organic cation transporter 1 (OCT1) is one of the membrane proteins in the large solute carrier (SLC) family. It participates in the transport of organic cations, i.e. nutrients, neurotransmitters, metabolites or drugs in an electrogenic manner and translocate various cationic cytostatics.
Ewa, Stefanko +6 more
openaire +2 more sources