Results 11 to 20 of about 6,916 (201)

Enforcement of developmental lineage specificity by transcription factor Oct1 [PDF]

eLife, 2017
Embryonic stem cells co-express Oct4 and Oct1, a related protein with similar DNA-binding specificity. To study the role of Oct1 in ESC pluripotency and transcriptional control, we constructed germline and inducible-conditional Oct1-deficient ESC lines ...
Zuolian Shen, Jinsuk Kang, Arvind Shakya, Marcin Tabaka, Elke A Jarboe, Aviv Regev, Dean Tantin   +6 more
doaj   +5 more sources

Transcription factor Oct1 is a somatic and cancer stem cell determinant.

PLoS Genetics, 2012
Defining master transcription factors governing somatic and cancer stem cell identity is an important goal. Here we show that the Oct4 paralog Oct1, a transcription factor implicated in stress responses, metabolic control, and poised transcription states,
Jessica Maddox, Arvind Shakya, Samuel South, Dawne Shelton, Jared N Andersen, Stephanie Chidester, Jinsuk Kang, Keith M Gligorich, David A Jones, Gerald J Spangrude, Bryan E Welm, Dean Tantin   +11 more
doaj   +4 more sources

OCT1 Mediates Hepatic Uptake of Sumatriptan and Loss-of-Function OCT1 Polymorphisms Affect Sumatriptan Pharmacokinetics

Clinical Pharmacology & Therapeutics, 2016
The low bioavailability of the anti-migraine drug sumatriptan is partially caused by first-pass hepatic metabolism. In this study, we analyzed the impact of the hepatic organic cation transporter OCT1 on sumatriptan cellular uptake, and of OCT1 ...
Knoch, T., Matthaei, Johannes, Faltraco, F., Tzvetkov, Mladen Vassilev, Abu Abed, Manar, Prukop, Thomas, Brockmoeller, Juergen, Pereira, J. N. Dos Santos, Kuron, D.   +8 more
core   +4 more sources

OCT1 regulates the migration of colorectal cancer cells by acting on LDHA [PDF]

Histology and histopathology, 2023
Colorectal cancer is one of the most common cancers with high morbidity and mortality. Effective treatments to improve the prognosis are still lacking.
Sun, Peichun, Chen, Wenchao, Wu, Gang, Li, Lihua   +3 more
core   +3 more sources

Oct1 regulates trophoblast development during early mouse embryogenesis [PDF]

Development, 2010
Oct1 (Pou2f1) is a transcription factor of the POU-homeodomain family that is unique in being ubiquitously expressed in both embryonic and adult mouse tissues.
Karin Hübner, Julien Sutter, Fatima Cavaleri, Marcos Jesus Arauzo Bravo, Hans Robert Schöler, Jin-Young Ju, Guang-Ming Wu, Daniel Esch, Luca Gentile, Natalia Tapia, Mathieu Dalvai, Vittorio Sebastiano, Karin Schubart, Patrick Matthias   +13 more
core   +3 more sources

Oct1/Pou2f1 is selectively required for colon regeneration and regulates colon malignancy.

PLoS Genetics, 2019
The transcription factor Oct1/Pou2f1 promotes poised gene expression states, mitotic stability, glycolytic metabolism and other characteristics of stem cell potency. To determine the effect of Oct1 loss on stem cell maintenance and malignancy, we deleted
Karina Vázquez-Arreguín, Claire Bensard, John C Schell, Eric Swanson, Xinjian Chen, Jared Rutter, Dean Tantin   +6 more
doaj   +2 more sources

Inter-Subject Variability in OCT1 Activity in 27 Batches of Cryopreserved Human Hepatocytes and Association with OCT1 mRNA Expression and Genotype

Pharmaceutical Research, 2017
Purpose: OCT1/3 (Organic Cation Transporter-1 and -3; SLC22A1/3) are transmembrane proteins localized at the basolateral membrane of hepatocytes. They mediate the uptake of cationic endogenous compounds and/or xenobiotics. The present study was set up to
Richert, L, Maja, Matic, Matic, Maja; id_orcid, Fattah, S, Baes, M, Patrick Augustijns, Sarinj Fattah, Augustijns, Patrick, van Schaik, Ron, Karel Allegaert, Augustijns, P, Celine Parmentier, van Schaik, Ron H.N., Abhijit Babaji Shinde, Annaert, Pieter, Richert, Lysiane, Baes, Myriam, Lysiane Richert, Shinde, AB, Allegaert, Karel; id_orcid, Maja Matic, Fattah, Sarinj, Myriam Baes, Ron H. N. van Schaik, Shinde, Abhijit Babaji, Parmentier, Celine, Allegaert, Karel, Annaert, P, Parmentier, C, Pieter Annaert   +29 more
core   +3 more sources

T cell-selective deletion of Oct1 protects animals from autoimmune neuroinflammation while maintaining neurotropic pathogen response [PDF]

Journal of Neuroinflammation, 2019
Background Treatments for autoimmune diseases aim to dampen autoreactivity while preserving normal immune function. In CD4+ T cells, the transcription factor Oct1/Pou2f1 is a dispensable transcription factor for T cell development and response to primary
Heejoo Kim, Laura Dickey, Colleen Stone, Jillian L. Jafek, Thomas E. Lane, Dean Tantin   +5 more
doaj   +2 more sources

Feed-Forward Deep Neural Networks Predict Substrate-Specific Effects of Transporter Variants to Explain Drug Response Variability. [PDF]

Clin Transl Sci
ABSTRACT Genetic variants in drug transporter genes shape the interindividual variability in drug response. However, their functional interpretation has remained limited due to the substrate dependence of variant effects. Existing predictors are substrate‐agnostic and cannot capture how a single amino acid change differentially affects transport across
Park Y, Zhou Y, Xiao M, Nies AT, Lauschke VM.   +4 more
europepmc   +2 more sources

Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake [PDF]

Drug Metabolism and Disposition, 2020
Organic cation transporter 1 (OCT1) plays a role in hepatic uptake of drugs, affecting in vivo exposure, distinguished primarily through pharmacogenetics of the SLC22A1 gene. The role of OCT1 in vivo has not been confirmed, however, via drug-drug interactions that similarly affect exposure.
Bridget L. Morse, Anil Kolur, Loyd R. Hudson, Andrew T. Hogan, Lisa Hong Chen, Ryan M. Brackman, Geri A. Sawada, John K. Fallon, Philip C. Smith, Kathleen M. Hillgren   +9 more
openaire   +2 more sources