Results 21 to 30 of about 24,056 (240)
Catecholamine transport by the organic cation transporter type 1 (OCT1) [PDF]
British Journal of Pharmacology, 1998 Liver and kidney extract adrenaline and noradrenaline from the circulation by a mechanism which does not seem to be one of the classical catecholamine transporters. The hypothesis that OCT1 is involved–the organic cation transporter type 1 which exists in rat kidney and liver–was tested.
T, Breidert +3 more
openaire +2 more sources
Intestinal OCTN2- and MCT1-targeted drug delivery to improve oral bioavailability
Asian Journal of Pharmaceutical Sciences, 2020 Various drug transporters are widely expressed throughout the intestine and play important roles in absorbing nutrients and drugs, thus providing high quality targets for the design of prodrugs or nanoparticles to facilitate oral drug delivery.
Gang Wang +8 more
doaj +1 more source
Biochemical Pharmacology, 2022 Stereoselectivity is important in many pharmacological processes but its impact on drug membrane transport is scarcely understood. Recent studies showed strong stereoselective effects in the cellular uptake of fenoterol by the organic cation transporters OCT1 and OCT2.
Gebauer, Lukas +4 more
openaire +4 more sources
Molecules, 2021 Carnitine insufficiency is reported in type 1 diabetes mellitus. To determine whether this is accompanied by defects in biosynthesis and/or renal uptake, liver and kidney were obtained from male Sprague-Dawley rats with streptozotocin-induced diabetes ...
Aman Upadhyay +2 more
doaj +1 more source
Current Research in Pharmacology and Drug Discovery, 2023 The high levels of bile acids are a critical factor in hepatorenal syndrome. Organic solute transporter α/β (Ostα/β) participate in bile acids reabsorption in the kidney.
Xiaojuan Zhao +6 more
doaj +1 more source
Biomedicines, 2020 Organic cation transporters (OCTs) and novel organic cation transporters (OCTNs) are responsible for drug delivery in the intestine and kidney; in the lung, OCTs mediate inhaled drugs’ transport, although their physiological role in airways remains ...
Amelia Barilli +7 more
doaj +1 more source
Pharmaceutics, 2021 Gastrointestinal tract absorption of cationic anticancer drugs and medicines was estimated using whole-body imaging following oral [123I]MIBG administration.
Masato Kobayashi +9 more
doaj +1 more source
Tenofovir Disoproxil Fumarate Is Not an Inhibitor of Human Organic Cation Transporter 1 [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2017 This letter to editor is to provide commentary on results presented in “Transport of lamivudine [(−)- β -l-2',3'-dideoxy-3'-thiacytidine] and high-affinity interaction of nucleoside reverse transcriptase inhibitors with human organic cation transporters 1, 2, and 3” reported by [Minuesa et ...
Hong, Shen +3 more
openaire +2 more sources
Molecules, 2013 The potent anti-hyperuricemia activities of Fructus Gardenia Extract (FGE) have been well reported. The aim of this study was to evaluate the uricosuric and nephro-protective effects of FGE and explore its possible mechanisms of action in oxonate-induced
Hui Ji +5 more
doaj +1 more source
Response to “Tenofovir Disoproxil Fumarate Is Not an Inhibitor of Human Organic Cation Transporter 1” [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2017 On the basis of experiments reported in their letter, Shen and coworkers concluded that tenofovir disoproxil fumarate (TDF) is not an inhibitor of human organic cation transporter 1 (OCT1). They expressed their concern that high-affinity inhibition of the uptake of N- methyl - 4-phenylpyridinium (
Minuesa G +4 more
openaire +4 more sources