Stereoselectivity in Cell Uptake by SLC22 Organic Cation Transporters 1, 2, and 3
Journal of Medicinal Chemistry, 2023 Stereoselectivity can be most relevant in drug metabolism and receptor binding. Although drug membrane transport might be equally important for small-molecule pharmacokinetics, the extent of stereoselectivity in membrane transport is largely unknown.
Lukas Gebauer +3 more
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Imbalance of Drug Transporter-CYP450s Interplay by Diabetes and Its Clinical Significance
Pharmaceutics, 2020 The pharmacokinetics of a drug is dependent upon the coordinate work of influx transporters, enzymes and efflux transporters (i.e., transporter-enzyme interplay). The transporter–enzyme interplay may occur in liver, kidney and intestine.
Yiting Yang, Xiaodong Liu
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Inhibition of Human Drug Transporter Activities by the Pyrethroid Pesticides Allethrin and Tetramethrin. [PDF]
PLoS ONE, 2017 Pyrethroids are widely-used chemical insecticides, to which humans are commonly exposed, and known to alter functional expression of drug metabolizing enzymes. Limited data have additionally suggested that drug transporters, that constitute key-actors of
Lisa Chedik +7 more
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The Potentials of Ergothioneine in the management of diseases in animals
Media Kedokteran Hewan, 2023 The amino acid histidine is the source of the special nutraceutical ergothioneine (ERG), which is a potent antioxidant. Higher plants and animals, who obtain it from the soil and their food, respectively, do not synthesize it; instead, they obtain it ...
Adakole Adah
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Genistein ameliorates hyperuricemia-associated nephropathy in hyperuricemic mice
Food and Agricultural Immunology, 2021 Hyperuricemia is a metabolic disease caused by excessive production of uric acid (UA), which can cause gout, hypertension, hyperlipidemia and other diseases.
Bi Wei-Yun, Zhu Cailin
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Viruses, 2021 Islatravir (MK-8591) is a nucleoside reverse transcriptase translocation inhibitor in development for the treatment and prevention of HIV-1. The potential for islatravir to interact with commonly co-prescribed medications was studied in vitro ...
Kelly Bleasby +7 more
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Enhanced and Persistent Inhibition of Organic Cation Transporter 1 Activity by Preincubation of Cyclosporine A [PDF]
Drug Metabolism and Disposition, 2019 Recent pharmacogenetic evidence indicates that hepatic organic cation transporter (OCT) 1 can serve as the locus of drug-drug interactions (DDIs) with significant pharmacokinetic and pharmacodynamic consequences. We examined the impact of preincubation on the extent of OCT1 inhibition in transfected human embryonic kidney 293 (HEK293) cells.
Erika, Panfen +6 more
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Cadmium Uptake by Wheat (Triticum aestivum L.): An Overview
Plants, 2020 Cadmium is a toxic heavy metal that may be detected in soils and plants. Wheat, as a food consumed by 60% of the world’s population, may uptake a high quantity of Cd through its roots and translocate Cd to the shoots and grains thus posing risks to human
Tayebeh Abedi, Amin Mojiri
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Association between the synonymous variant organic cation transporter 3 (OCT3)-1233G>A and the glycemic response following metformin therapy in patients with type 2 diabetes [PDF]
Iranian Journal of Basic Medical Sciences, 2017 Objective(s): Organic cation transporter 3 (OCT3) as a high-capacity transporter contribute to the metabolism of metformin. The present study was conducted to determine the genotype frequencies of the variant OCT3-1233G>A (rs2292334) in patients with ...
Seyyedeh Raheleh Hosseyni-Talei +4 more
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Down-regulation of the organic cation transporter 1 of rat liver in obstructive cholestasis [PDF]
Hepatology, 2004 The liver plays a major role in biotransformation and elimination of various therapeutic agents and xenobiotics, many of which are organic cations and substrates of the organic cation transporter 1 (Oct1, Slc22a1). Oct1 is expressed at the basolateral membranes of hepatocytes and proximal renal tubules.
Denk, Gerald U. +5 more
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