Results 41 to 50 of about 24,056 (240)

Identification of a kidney-specific mouse organic cation transporter like-1 (mOCTL1) [PDF]

Experimental & Molecular Medicine, 2007
Organic ion transporters are expressed in various tissues that transport endogenous and exogenous compounds including their metabolites. There are organic anion transporter (OAT), organic cation transporter (OCT), organic anion transporter like protein (OATLP) and organic cation transporter like (OCTL).
Woon Kyu, Lee, Ji-Sun, Hwang, Cheol-Heui, Yun, Seok Ho, Cha   +3 more
openaire   +3 more sources

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Influence of YES1 Kinase and Tyrosine Phosphorylation on the Activity of OCT1

Frontiers in Pharmacology, 2021
Organic cation transporter 1 (OCT1) is a transporter that regulates the hepatic uptake and subsequent elimination of diverse cationic compounds. Although OCT1 has been involved in drug-drug interactions and causes pharmacokinetic variability of many ...
Muhammad Erfan Uddin, Dominique A. Garrison, Kyeongmin Kim, Yan Jin, Eric D. Eisenmann, Kevin M. Huang, Alice A. Gibson, Zeping Hu, Alex Sparreboom, Shuiying Hu   +9 more
doaj   +1 more source

Discovery of Competitive and Noncompetitive Ligands of the Organic Cation Transporter 1 (OCT1; SLC22A1) [PDF]

Journal of Medicinal Chemistry, 2017
Organic cation transporter 1 (OCT1) plays a critical role in the hepatocellular uptake of structurally diverse endogenous compounds and xenobiotics. Here we identified competitive and noncompetitive OCT1-interacting ligands in a library of 1780 prescription drugs by combining in silico and in vitro methods.
Eugene C. Chen, Natalia Khuri, Xiaomin Liang, Adrian Stecula, Huan-Chieh Chien, Sook Wah Yee, Yong Huang, Andrej Sali, Kathleen M. Giacomini   +8 more
openaire   +4 more sources

Stereoselectivity in the Membrane Transport of Phenylethylamine Derivatives by Human Monoamine Transporters and Organic Cation Transporters 1, 2, and 3

Biomolecules, 2022
Stereoselectivity is well known and very pronounced in drug metabolism and receptor binding. However, much less is known about stereoselectivity in drug membrane transport. Here, we characterized the stereoselective cell uptake of chiral phenylethylamine derivatives by human monoamine transporters (NET, DAT, and SERT) and organic cation transporters ...
Gebauer, Lukas, Rafehi, Muhammad, Brockmöller, Jürgen, Krause, Frank   +3 more
openaire   +5 more sources

Mycobacterial cell division arrest and smooth‐to‐rough envelope transition using CRISPRi‐mediated genetic repression systems

FEBS Open Bio, EarlyView.
CRISPRI‐mediated gene silencing and phenotypic exploration in nontuberculous mycobacteria. In this Research Protocol, we describe approaches to control, monitor, and quantitatively assess CRISPRI‐mediated gene silencing in M. smegmatis and M. abscessus model organisms.
Vanessa Point, Wafaa Achache, Janïs Laudouze, Eliana Sepulveda Ramos, Mickaël Maziero, Céline Crauste, Stéphane Canaan, Pierre Santucci   +7 more
wiley   +1 more source

Effect of Genetic Variation in the Organic Cation Transporter 1, OCT1, on Metformin Pharmacokinetics [PDF]

Clinical Pharmacology & Therapeutics, 2007
The goal of this study was to determine the effects of genetic variation in the organic cation transporter 1, OCT1, on the pharmacokinetics of the antidiabetic drug, metformin. Twenty healthy volunteers with known OCT1 genotype agreed to participate in the study.
Y, Shu, C, Brown, R A, Castro, R J, Shi, E T, Lin, R P, Owen, S A, Sheardown, L, Yue, E G, Burchard, C M, Brett, K M, Giacomini   +10 more
openaire   +2 more sources

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

In vitro investigations into the roles of CYP450 enzymes and drug transporters in the drug interactions of zanubrutinib, a covalent Bruton's tyrosine kinase inhibitor

Pharmacology Research & Perspectives, 2021
Zanubrutinib is a highly selective, potent, orally available, targeted covalent inhibitor (TCI) of Bruton's tyrosine kinase (BTK). This work investigated the in vitro drug metabolism and transport of zanubrutinib, and its potential for clinical drug–drug
Heather Zhang, Ying C. Ou, Dan Su, Fan Wang, Lai Wang, Srikumar Sahasranaman, Zhiyu Tang   +6 more
doaj   +1 more source

Identification of the Tetraspanin CD9 as an Interaction Partner of Organic Cation Transporters 1 and 2 [PDF]

SLAS Discovery, 2019
Organic cation transporters (OCTs) are membrane proteins with relevant physiological (because they accept neurotransmitters as substrate) and pharmacological (because of their interaction with drugs) roles. The human OCTs hOCT1 (SLC22A1/hOCT1) and hOCT2 (SLC22A2/hOCT2) are highly expressed in hepatic (hOCT1) and in renal and neuronal tissue (hOCT2 ...
Snieder, Beatrice, Brast, Sabine, Grabner, Alexander, Buchholz, Sven, Schröter, Rita, Spoden, Gilles A., Florin, Luise, Salomon, Johanna, Albrecht, Tobias, Barz, Vivien, Sparreboom, Alex, Ciarimboli, Giuliano   +11 more
openaire   +2 more sources