Proteolysis-Targeting Chimera (PROTAC) Delivery into the Brain across the Blood-Brain Barrier
Antibodies, 2023 Drug development for neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, and Huntington’s disease has challenging difficulties due to the pharmacokinetic impermeability based on the blood-brain barrier (BBB) as well as the ...
Toshihiko Tashima
doaj +1 more source
The impact of genetic polymorphisms in organic cation transporters on renal drug disposition [PDF]
, 2020 A considerable number of drugs and/or their metabolites are excreted by the kidneys through glomerular filtration and active renal tubule secretion via transporter proteins.
Vijverberg, Susanne J. H. +14 more
core +2 more sources
Impairment of exocytotic transmitter release by decynium-22 through an inhibition of ion channels
Frontiers in Pharmacology, 2023 Introduction: In addition to members of the family of Na+/Cl− dependent monoamine transporters, organic cation transporters (OCTs), in particular OCT3, as well as the plasma membrane monoamine transporter (PMAT) may contribute to neuronal reuptake of ...
Gabriele Haar +4 more
doaj +1 more source
Carrier-Mediated and Energy-Dependent Uptake and Efflux of Deoxynivalenol in Mammalian Cells
Scientific Reports, 2017 Deoxynivalenol (DON) is one of the most abundant mycotoxins and exerts many adverse effects on humans and animals. To date, the transporting mechanism of DON in mammalian cells remains unclear. In this study, the parallel artificial membrane permeability
Xiaoming Li +3 more
doaj +1 more source
Warm seawater temperature promotes substrate colonization by the blue coral, Heliopora coerulea [PDF]
PeerJ, 2019 Background Heliopora coerulea, the blue coral, is a reef building octocoral that is reported to have a higher optimum temperature for growth compared to most scleractinian corals.
Christine Guzman +4 more
doaj +2 more sources
Evidence for organic cation transporter-mediated metformin transport and 5′-adenosine monophosphate-activated protein kinase activation in rat skeletal muscles [PDF]
Metabolism, 2015 5'-Adenosine monophosphate-activated protein kinase (AMPK) is a key molecule of metabolic enhancement in skeletal muscle. We investigated whether metformin (MET) acts directly on skeletal muscle, is transported into skeletal muscle via organic cation transporters (OCTs), and activates AMPK.Isolated rat epitrochlearis and soleus muscles were incubated ...
Oshima, Rieko +8 more
openaire +2 more sources
Ischemia/Reperfusion-Inducible Protein Modulates the Function of Organic Cation Transporter 1 and Multidrug and Toxin Extrusion 1 [PDF]
Molecular Pharmaceutics, 2013 The recently identified ischemia/reperfusion-inducible protein (IRIP) has been reported to negatively modulate the activities of several transporters in cell culture systems. The goal of this study is to determine whether IRIP regulates the activities of OCT1 and MATE1, and hence the disposition in vivo of their substrate metformin, a therapeutic drug ...
Qing, Li +6 more
openaire +2 more sources
, 2020 The information derived from next generation sequencing technology allows the identification of deregulated genes, gene mutations, epigenetic modifications, and other genomic events that are associated with a given tumor entity.
Bayram Edemir
core +1 more source
Carnitine Traffic in Cells. Link With Cancer
Frontiers in Cell and Developmental Biology, 2020 Metabolic flexibility is a peculiar hallmark of cancer cells. A growing number of observations reveal that tumors can utilize a wide range of substrates to sustain cell survival and proliferation.
Lara Console +8 more
doaj +1 more source
Molecular Information Technology [PDF]
, 2005 Molecular materials are endowed with unique properties of unrivaled potential for high density integration of computing systems. Present applications of molecules range from organic semiconductor materials for low-cost circuits to genetically modified ...
Zauner, Klaus-Peter, Klaus-Peter Zauner
core +1 more source