Results 11 to 20 of about 36,235 (291)

Physiological and Putative Organic Cation Transporter Expression Response to Alizarin Dye Exposure in Aedes aegypti Mosquitoes [PDF]

Insects
There remains an urgent need for knowledge regarding the molecular and genetic mechanisms in Aedes aegypti to support the fight against mosquito-borne illness, one of these areas being xenobiotic transport.
Naomi R. Kennel, Matthew F. Rouhier
doaj   +2 more sources

Structural and biochemical comparison of the FLVCR and CTL membrane protein families in eukaryotes [PDF]

Life Science Alliance
Structure–function analysis supports that the FLVCR membrane protein family acts as choline transporters, whereas a nontransport role is suggested for the CTL membrane protein family, previously proposed to be choline transporters.
Lynette Nel, Jan H Driller, Ronja Driller, Kelly M Frain, Bjørn P Pedersen   +4 more
doaj   +2 more sources

Interactions of Tyrosine Kinase Inhibitors with Organic Cation Transporters and Multidrug and Toxic Compound Extrusion Proteins [PDF]

Molecular Cancer Therapeutics, 2011
Abstract The drug–drug interaction (DDI) potential of tyrosine kinase inhibitors (TKI) as interacting drugs via transporter inhibition has not been fully assessed. Here, we estimated the half maximal inhibitory concentration (IC50) values for 8 small-molecule TKIs (imatinib, dasatinib, nilotinib, gefitinib, erlotinib, sunitinib ...
Tsuyoshi, Minematsu, Kathleen M, Giacomini   +1 more
openaire   +3 more sources

Stress regulated members of the plant organic cation transporter family are localized to the vacuolar membrane

BMC Research Notes, 2008
Background In Arabidopsis six genes group into the gene family of the organic cation transporters (OCTs). In animals the members of the OCT-family are mostly characterized as polyspecific transporters involved in the homeostasis of solutes, the transport
Koch Wolfgang, Küfner Isabell
doaj   +2 more sources

Organic Cation Transporters in Human Physiology, Pharmacology, and Toxicology [PDF]

, 2020
Individual cells and epithelia control the chemical exchange with the surrounding environment by the fine-tuned expression, localization, and function of an array of transmembrane proteins that dictate the selective permeability of the lipid bilayer to ...
Gai, Zhibo; https://orcid.org/, Visentin, Michele; https://orcid.org/, Kullak-Ublick, Gerd A; https://orcid.org/, Samodelov, Sophia L; https://orcid.org/   +3 more
core   +2 more sources

Inhibitory Effects of Green Tea and (-)-Epigallocatechin Gallate on Transport by OATP1B1, OATP1B3, OCT1, OCT2, MATE1, MATE2-K and P-Glycoprotein. [PDF]

PLoS ONE, 2015
Green tea catechins inhibit the function of organic anion transporting polypeptides (OATPs) that mediate the uptake of a diverse group of drugs and endogenous compounds into cells.
Jana Knop, Shingen Misaka, Katrin Singer, Eva Hoier, Fabian Müller, Hartmut Glaeser, Jörg König, Martin F Fromm   +7 more
doaj   +1 more source

The Strange Case: The Unsymmetric Cisplatin-Based Pt(IV) Prodrug [Pt(CH3COO)Cl2(NH3)2(OH)] Exhibits Higher Cytotoxic Activity with respect to Its Symmetric Congeners due to Carrier-Mediated Cellular Uptake

Bioinorganic Chemistry and Applications, 2022
The biological behavior of the axially unsymmetric antitumor prodrug (OC-6-44)-acetatodiamminedichloridohydroxidoplatinum(IV), 2, was deeply investigated and compared with that of analogous symmetric Pt(IV) complexes, namely, dihydroxido 1 and diacetato ...
Elisabetta Gabano, Ilaria Zanellato, Giulia Pinton, Laura Moro, Mauro Ravera, Domenico Osella   +5 more
doaj   +1 more source

Divergent molecular responses of greater amberjack (Seriola dumerili) to acute salinity stress revealed by comparative transcriptome analysis

Frontiers in Marine Science, 2023
Greater amberjack (Seriola dumerili) is an important commercial fish for its high growth rate and excellent flesh quality. However, its sensitivity to variations of water salinity poses challenges to the cage culture. In this study, the greater amberjack
Yuqi Liu, Yuqi Liu, Yuqi Liu, Yuchen Yang, Yuchen Yang, Ruotong Qin, Yuhao Peng, Yang Huang, Chunhua Zhu, Chunhua Zhu, Guangli Li, Dongneng Jiang, Hongjuan Shi   +12 more
doaj   +1 more source

Developmental Changes in Hepatic Organic Cation Transporter OCT1 Protein Expression from Neonates to Children [PDF]

Drug Metabolism and Disposition, 2017
Organic cation transporter 1 (OCT1) plays an important role in the disposition of clinically important drugs, and the capacity of OCT1 activity is presumed to be proportional to the protein expression level in organ tissues. Knowledge of OCT1 protein expression in children, especially neonates and small infants, is currently very limited.
David, Hahn, Chie, Emoto, Alexander A, Vinks, Tsuyoshi, Fukuda   +3 more
openaire   +2 more sources

Atypical Substrates of the Organic Cation Transporter 1

, 2022
The human organic cation transporter 1 (OCT1) is expressed in the liver and mediates hepatocellular uptake of organic cations. However, some studies have indicated that OCT1 could transport neutral or even anionic substrates.
Redeker, Kyra-Elisa Maria, Ole Jensen, Jensen, Ole, Lukas Gebauer, Meyer-Tönnies, Marleen Julia, Kyra-Elisa Maria Redeker, Marleen Julia Meyer-Tönnies, Brockmöller, Jürgen, Gebauer, Lukas, Jürgen Brockmöller   +9 more
core   +1 more source