Results 11 to 20 of about 34,801 (229)
Pharmaceuticals, 2018 Hepcidin is a key hormonal regulator of systemic iron homeostasis and its expression is induced by iron or inflammatory stimuli. Genetic defects in iron signaling to hepcidin lead to “hepcidinopathies„ ranging from hereditary hemochromatosis ...
Angeliki Katsarou, Kostas Pantopoulos
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Hepcidin antagonists for potential treatments of disorders with hepcidin excess [PDF]
Frontiers in Pharmacology, 2014 5noThe discovery of hepcidin clarified the basic mechanism of the control of systemic iron homeostasis. Hepcidin is mainly produced by the liver as a propeptide and processed by furin into the mature active peptide.
Maria Regoni +4 more
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[Rinsho ketsueki] The Japanese journal of clinical hematology, 2017 Hepcidin is an iron-regulating peptide hormone made in the liver. It controls the delivery of iron to blood plasma from intestinal cells absorbing iron, from erythrocyte-recycling macrophages, and from iron-storing hepatocytes. Hepcidin acts by binding to and inactivating the sole cellular iron exporter, ferroportin, which delivers iron to plasma from ...
A. M. Gressner, O. A. Gressner
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Molecular Mechanisms Regulating Hepcidin Revealed by Hepcidin Disorders [PDF]
The Scientific World JOURNAL, 2011 Iron is essential for human life, but toxic if present in excess. To avoid iron overload and maintain iron homeostasis, all cells are able to regulate their iron content through the post-transcriptional control of iron genes operated by the cytosolic iron regulatory proteins that interact with iron responsive elements on iron gene mRNA. At the systemic
CAMASCHELLA , CLARA, SILVESTRI L.
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Clinical Journal of the American Society of Nephrology, 2009 Despite the use of erythropoiesis-stimulating agents (ESAs), the anemia of chronic kidney disease (CKD) can be resistant to therapy. Both absolute and functional iron deficiency along with inflammation can contribute to ESA resistance and can be difficult to identify with current-day markers of iron storage.
Brian, Young, Joshua, Zaritsky
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JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH, 2013 Iron related disorders are encountered in daily clinical settings. Maintenance of stable extracellular iron concentrations requires the coordinate regulation of iron transport into plasma from dietary sources in the duodenum, from recycled senescent red cells in macrophages and from storage in hepatocytes.
Subha Palaneeswari M. +4 more
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Hepcidin and iron homeostasis during pregnancy. [PDF]
, 2014 Hepcidin is the master regulator of systemic iron bioavailability in humans. This review examines primary research articles that assessed hepcidin during pregnancy and postpartum and report its relationship to maternal and infant iron status and birth ...
Cadwell, Brooke +4 more
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, 2022 The hepcidin is antimicrobial peptide has antimicrobial effects discover before more than a thousand years; it has a great role in iron metabolism and innate immunity. Hepcidin is a regulator of iron homeostasis. Its production is increased by iron excess and inflammation and decreased by hypoxia and anemia.
A., Faraj, Safa, M., Al-Abedy, Naeem
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Protective Role of Hepcidin in Polymicrobial Sepsis and Acute Kidney Injury
Frontiers in Pharmacology, 2019 Background: Acute kidney injury (AKI) portends worse prognosis following sepsis, with limited available interventions. Host iron acquisition by pathogens and systemic inflammatory response are key events in the pathogenesis of sepsis. In sepsis, hepcidin
Yogesh Scindia +7 more
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Hemojuvelin-Neogenin Interaction Is Required for Bone Morphogenic Protein-4-induced Hepcidin Expression [PDF]
, 2009 Hemojuvelin (HJV) is a glycosylphosphatidylinositol-linked protein and binds both bone morphogenic proteins (BMPs) and neogenin. Cellular HJV acts as a BMP co-receptor to enhance the transcription of hepcidin, a key iron regulatory hormone secreted ...
An-Sheng Zhang +44 more
core +4 more sources