Results 11 to 20 of about 25,679 (210)
Clinical interpretation of serum hepcidin-25 in inflammation and renal dysfunction
Journal of Mass Spectrometry and Advances in the Clinical Lab, 2022 Introduction: Hepcidin is a hormone that regulates systemic iron homeostasis. Serum hepcidin levels are under the influence of various stimuli, particularly inflammation and renal dysfunction.
Michael X. Chen +5 more
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Low Serum Hepcidin in Patients with Autoimmune Liver Diseases. [PDF]
PLoS ONE, 2015 Hepcidin, a liver hormone, is important for both innate immunity and iron metabolism regulation. As dysfunction of the hepcidin pathway may contribute to liver pathology, we analysed liver hepcidin mRNA and serum hepcidin in patients with chronic liver ...
Aggeliki Lyberopoulou +12 more
doaj +1 more source
Hepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent. [PDF]
PLoS ONE, 2012 Hepcidin is an antimicrobial peptide, which also negatively regulates iron in circulation by controlling iron absorption from dietary sources and iron release from macrophages.
Xinggang Wu +6 more
doaj +1 more source
Clinical Journal of the American Society of Nephrology, 2009 Despite the use of erythropoiesis-stimulating agents (ESAs), the anemia of chronic kidney disease (CKD) can be resistant to therapy. Both absolute and functional iron deficiency along with inflammation can contribute to ESA resistance and can be difficult to identify with current-day markers of iron storage.
Brian, Young, Joshua, Zaritsky
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Molecular Mechanisms Regulating Hepcidin Revealed by Hepcidin Disorders [PDF]
The Scientific World JOURNAL, 2011 Iron is essential for human life, but toxic if present in excess. To avoid iron overload and maintain iron homeostasis, all cells are able to regulate their iron content through the post-transcriptional control of iron genes operated by the cytosolic iron regulatory proteins that interact with iron responsive elements on iron gene mRNA. At the systemic
CAMASCHELLA , CLARA, SILVESTRI L.
openaire +4 more sources
Frontiers in Immunology, 2021 Lung cancer has the highest death rate among cancers globally. Hepcidin is a fascinating regulator of iron metabolism; however, the prognostic value of hepcidin and its correlation with immune cell infiltration in lung cancer remain unclear.
Yumei Fan +9 more
doaj +1 more source
eLife, 2022 The iron hormone hepcidin is transcriptionally activated by iron or inflammation via distinct, partially overlapping pathways. We addressed how iron affects inflammatory hepcidin levels and the ensuing hypoferremic response. Dietary iron overload did not
Edouard Charlebois +8 more
doaj +1 more source
Protective Role of Hepcidin in Polymicrobial Sepsis and Acute Kidney Injury
Frontiers in Pharmacology, 2019 Background: Acute kidney injury (AKI) portends worse prognosis following sepsis, with limited available interventions. Host iron acquisition by pathogens and systemic inflammatory response are key events in the pathogenesis of sepsis. In sepsis, hepcidin
Yogesh Scindia +7 more
doaj +1 more source
Iron status and systemic inflammation, but not gut inflammation, strongly predict gender-specific concentrations of serum hepcidin in infants in rural Kenya. [PDF]
PLoS ONE, 2013 Hepcidin regulation by competing stimuli such as infection and iron deficiency has not been studied in infants and it's yet unknown whether hepcidin regulatory pathways are fully functional in infants.
Tanja Jaeggi +8 more
doaj +1 more source
A tincture of hepcidin cures all: the potential for hepcidin therapeutics [PDF]
Journal of Clinical Investigation, 2010 Iron overload as a result of blood transfusions and excessive intestinal iron absorption can be a complication of chronic anemias such as β-thalassemia. Inappropriately low levels of hepcidin, a negative regulator of iron absorption and recycling, underlie the pathophysiology of the intestinal hyperabsorption. In this issue of the JCI, Gardenghi et al.
Thomas B, Bartnikas, Mark D, Fleming
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