Results 11 to 20 of about 30,077 (251)
Identification of an iron–hepcidin complex [PDF]
Biochemical Journal, 2008 Following its identification as a liver-expressed antimicrobial peptide, the hepcidin peptide was later shown to be a key player in iron homoeostasis. It is now proposed to be the ‘iron hormone’ which, by interacting with the iron transporter ferroportin, prevents further iron import into the circulatory system.
Farnaud, Sébastien +5 more
core +12 more sources
Advances in Chronic Kidney Disease, 2019 Dysregulation of metabolism and utilization of iron can lead to the development and maintenance of anemia of CKD. Anemia is prevalent among patients with CKD. The markers of iron sufficiency or availability of iron are far from perfect which results in inaccurate diagnosis and treatment of anemia with poor outcomes.
Anil K, Agarwal, Jerry, Yee
core +4 more sources
Hepcidin in hepatocellular carcinoma [PDF]
British Journal of Cancer, 2022 AbstractHepatocellular carcinoma (HCC) is one of the most common reasons for cancer-related deaths. Excess iron increases HCC risk. Inevitably, hepcidin, the iron hormone that maintains systemic iron homoeostasis is involved in HCC pathology. Distinct from other cancers that show high hepcidin expression, HCC patients can show low hepcidin levels. Thus,
Jonathan H. Joachim, Kosha J. Mehta
openaire +4 more sources
Clinical Journal of the American Society of Nephrology, 2009 Despite the use of erythropoiesis-stimulating agents (ESAs), the anemia of chronic kidney disease (CKD) can be resistant to therapy. Both absolute and functional iron deficiency along with inflammation can contribute to ESA resistance and can be difficult to identify with current-day markers of iron storage.
Brian, Young, Joshua, Zaritsky
core +4 more sources
Hepcidin- A Burgeoning Biomarker [PDF]
National Journal of Laboratory Medicine, 2017 The discovery of hepcidin has triggered a virtual ignition of studies on iron metabolism and related disorders. The peptide hormone hepcidin is a key homeostatic regulator of iron metabolism.
Hemkant Manikrao Deshmukh +3 more
doaj +2 more sources
Mechanistic Insights Into Hepatotoxicity‐Induced Liver Cirrhosis and Anemia: Iron Dysregulation, the Hepcidin–Ferroportin Axis, and Emerging Therapeutic Strategies [PDF]
Organ Medicine, Volume 3, Issue 3, Page 171-185, September 2026.Patients with alcohol‐associated liver cirrhosis or acetaminophen (APAP) toxicity frequently develop anemia with iron metabolism disturbances. Dysregulation of hepcidin–ferroportin signaling, along with inflammation, oxidative stress, hypoxia, impaired intestinal iron absorption, malnutrition, and gastrointestinal bleeding, contributes to anemia ...
Debabrata Dash, Raj Kumar Koiri
openalex +2 more sources
Hepcidin regulation by BMP signaling in macrophages is lipopolysaccharide dependent. [PDF]
PLoS ONE, 2012 Hepcidin is an antimicrobial peptide, which also negatively regulates iron in circulation by controlling iron absorption from dietary sources and iron release from macrophages.
Xinggang Wu +6 more
doaj +1 more source
Hepcidin as a Molecular Hub of Iron Homeostasis: From BMP-SMAD Signaling to Therapeutic Modulation. [PDF]
BiomoleculesDuminuco A +10 more
europepmc +2 more sources
Hepcidin-induced iron deficiency of obesity.
, 2009 Hepcidin-induced iron deficiency of ...
Lisa. Tussing (7964675)
core +6 more sources
Discovery and quantification of proteins of biological relevance through differential proteomics and biosensing [PDF]
, 2012 Medical diagnosis is the process of attempting to determine and/or identify a possible disease or disorder. This process is revealed by biomarkers, defined by The Food and Drug Administration (FDA) as “characteristics that are objectively measured and
Lonardoni, Francesco
core +7 more sources