Results 31 to 40 of about 30,077 (251)
Understanding and exploiting hepcidin as an indicator of anemia due to chronic kidney disease
Kidney Research and Clinical Practice, 2013 Hepcidin, produced by the liver, is the master regulator of iron balance. Serum hepcidin is increased by high iron stores, blocks intestinal iron absorption, and impairs storage iron release.
Derek S. Larson, Daniel W. Coyne
doaj +1 more source
Inherited microcytic anemias due to disorders of iron and heme metabolism: An updated clinical review [PDF]
HemasphereAbstract Microcytic anemia is among the most common hematological abnormalities in clinical practice and is usually attributable to iron deficiency, thalassemia traits, or anemia of inflammation. A small but clinically important subset of patients, however, has inherited disorders of iron metabolism or heme synthesis presenting with persistent ...
Makis A, Saougou I, Hatzimichael E.
europepmc +2 more sources
Advances in Hematology, 2011 Hepcidin is upregulated by inflammation and iron. Inherited (HFE genotype) and treatment-related factors (blood units (BU), Iron overload) affecting hepcidin (measured by C-ELISA) were studied in 42 consecutive patients with AML prior to and after ...
Ann-Kathrin Eisfeld +8 more
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Hepcidin demonstrates a biphasic association with anemia in acute Plasmodium falciparum malaria
Haematologica, 2012 Hepcidin levels are high and iron absorption is limited in acute malaria. The mechanism(s) that regulate hepcidin secretion remain undefined. We have measured hepcidin concentration and cytokines in 100 Kenyan children with acute falciparum malaria and ...
Climent Casals-Pascual +6 more
doaj +1 more source
, 2022 The hepcidin is antimicrobial peptide has antimicrobial effects discover before more than a thousand years; it has a great role in iron metabolism and innate immunity. Hepcidin is a regulator of iron homeostasis. Its production is increased by iron excess and inflammation and decreased by hypoxia and anemia.
Safa A. Faraj, Naeem M. Al-Abedy
openaire +1 more source
Benefits and risks of iron supplementation in anemic neonatal pigs. [PDF]
, 2010 Iron deficiency is a common health problem. The most severe consequence of this disorder is iron deficiency anemia (IDA), which is considered the most common nutritional deficiency worldwide. Newborn piglets are an ideal model to explore the multifaceted
Thibaudeau, Olivier +12 more
core +2 more sources
SRM-MS Method Development for Hepcidin-25 Peptide
Journal of Analytical Methods in Chemistry, 2018 As advanced mass spectrometry- (MS-) based hepcidin analysis offers to overcome the limitations in analytical methods using antihepcidin, further improvement of MS detection sensitivity for the peptide may enhance the diagnostic value of the hepcidin for
Kyung-Cho Cho +5 more
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Hepcidin and Anemia: A Tight Relationship
Frontiers in Physiology, 2019 Hepcidin, the master regulator of systemic iron homeostasis, tightly influences erythrocyte production. High hepcidin levels block intestinal iron absorption and macrophage iron recycling, causing iron restricted erythropoiesis and anemia.
Alessia Pagani +5 more
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The pathophysiology and pharmacology of hepcidin [PDF]
Trends in Pharmacological Sciences, 2014 Inappropriate production of the iron-regulatory hormone hepcidin contributes to the pathogenesis of common iron disorders. Absolute or relative deficiency of hepcidin causes iron overload in hereditary hemochromatosis and iron-loading anemias. Elevated hepcidin causes iron restriction in inflammatory conditions including autoimmune disease, critical ...
Ruchala, Piotr, Nemeth, Elizabeta
openaire +4 more sources
Hepcidin, an emerging and important player in brain iron homeostasis
Journal of Translational Medicine, 2018 Hepcidin is emerging as a new important factor in brain iron homeostasis. Studies suggest that there are two sources of hepcidin in the brain; one is local and the other comes from the circulation.
Driton Vela
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