Results 51 to 60 of about 25,679 (210)

Predicting hepcidin level using inflammation markers and iron indicators in patients with anemia of chronic disease

Hematology, Transfusion and Cell Therapy, 2019
Background: Recently, a small peptide called Hepcidin, was found to have an important role in regulating the iron metabolism in anemia of chronic disease (ACD) patients.
Ketut Suega, Gde Raka Widiana
doaj   +1 more source

Revisiting Ferritin‐IgG Score to Predict Complete Biochemical Response in Autoimmune Hepatitis

Alimentary Pharmacology &Therapeutics, EarlyView.
The ferritin‐IgG score failed external validation in a large Spanish multicentre cohort. However, baseline IgG ≥ 1.89×ULN independently predicted both complete biochemical response and biochemical response (defined as transaminase normalization), identifying patients less likely to achieve timely remission with standard therapy.
Álvaro Díaz‐González, Bastian Engel, Manuel Hernández‐Guerra, Indhira Pérez‐Medrano, Beatriz Mateos, Rosa M. Morillas, Elena Gómez, Judith Gómez, Diana Horta, Isabel Conde, María Del Barrio, Ignasi Olivas, Ismael El Hajra, Mar Riveiro‐Barciela, Ana Barreira‐Díaz, Carmen López, Carmen Álvarez‐Navascúes, Manuel Rodríguez Perálvarez, Elmar Jaeckel, Richard Taubert, María‐Carlota Londoño   +20 more
wiley   +1 more source

Hepcidin and iron homeostasis

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, 2012
Despite fluctuations in dietary iron intake and intermittent losses through bleeding, the plasma iron concentrations in humans remain stable at 10-30 μM. While most of the iron entering blood plasma comes from recycling, appropriate amount of iron is absorbed from the diet to compensate for losses and maintain nontoxic amounts in stores.
Ganz, Tomas, Nemeth, Elizabeta
openaire   +2 more sources

Comparisons Between Serum Levels of Hepcidin and Leptin in Male College-Level Endurance Runners and Sprinters

Frontiers in Nutrition, 2021
Background: Hepcidin-25 is a 25 amino acid hepatokine and a key regulator of iron metabolism related to iron deficiency anemia. Recent studies have suggested that an elevated hepcidin level is correlated with low energy availability.
Shinsuke Nirengi, Shinsuke Nirengi, Hirokazu Taniguchi, Aya Ishibashi, Mami Fujibayashi, Nao Akiyama, Kazuhiko Kotani, Kazuhiko Kotani, Kengo Ishihara, Naoki Sakane   +9 more
doaj   +1 more source

Janus kinase inhibitors after ruxolitinib failure in myelofibrosis: A systematic review and pooled analysis of phase 3 efficacy and integrated safety across clinical trials and real‐world evidence

British Journal of Haematology, EarlyView.
Summary Ruxolitinib remains first‐line standard of care for symptomatic myelofibrosis, but resistance/intolerance develops in most patients. Three Janus kinase inhibitors (JAKis) have entered the post‐ruxolitinib space via distinct pivotal trials. We systematically searched prospective trials evaluating JAKi in refractory adults with myelofibrosis ...
Andrea Duminuco, Patrick Harrington, Elena Torre, Hillary Catellani, Novella Pugliese, Matteo Pacilli, Annalisa Santisi, Arianna Sbriglione, Giuseppe A. Palumbo   +8 more
wiley   +1 more source

Serum Hepcidin Levels and Reticulocyte Hemoglobin Concentrations as Indicators of the Iron Status of Peritoneal Dialysis Patients

International Journal of Nephrology, 2012
Hepcidin is the key mediator of renal anemia, and reliable measurement of serum hepcidin levels has been made possible by the ProteinChip system. We therefore investigated the iron status and serum hepcidin levels of peritoneal dialysis (PD) patients who
Aya Eguchi, Takahiro Mochizuki, Misao Tsukada, Koji Kataoka, Yukio Hamaguchi, Shinichiro Oguni, Kosaku Nitta, Ken Tsuchiya   +7 more
doaj   +1 more source

Hepcidin.

[Rinsho ketsueki] The Japanese journal of clinical hematology, 2016
Hepcidin is an iron-regulating peptide hormone made in the liver. It controls the delivery of iron to blood plasma from intestinal cells absorbing iron, from erythrocyte-recycling macrophages, and from iron-storing hepatocytes. Hepcidin acts by binding to and inactivating the sole cellular iron exporter, ferroportin, which delivers iron to plasma from ...
openaire   +2 more sources

Increased duodenal iron uptake and transfer in a rat model of chronic hypoxia is accompanied by reduced hepcidin expression [PDF]

, 2005
Background: Despite the requirement for increased iron delivery for erythropoiesis during hypoxia, there is very little information on how duodenal iron uptake and its transfer to the blood adapts to this condition.Aims: To assess the effects of 30 days ...
Mascarenhas, M, Churchill, LJ, Debnam, ES, Leung, PS, Srai, SK   +4 more
core  

The hepcidin‐ferroportin axis influences mitochondrial function, proliferation, and migration in pulmonary artery endothelial and smooth muscle cells

Pulmonary Circulation
Elevated circulating hepcidin levels have been reported in patients with pulmonary artery hypertension (PAH). Hepcidin has been shown to promote proliferation of human pulmonary artery smooth muscle cells (PASMCs) in vitro, suggesting a potential role in
Theo Issitt, Quezia K. Toe, Sofia L. Pedersen, Thomas Shackshaft, Maziah Mohd Ghazaly, Laura West, Nadine D. Arnold, Abdul Mahomed, George W. Kagugube, Latha Ramakrishnan, Allan Lawrie, Gregory J. Quinlan, S. John Wort   +12 more
doaj   +1 more source

Hepcidin as a risk marker for cardiovascular disease in periodontitis—A case control study

Journal of Indian Academy of Oral Medicine and Radiology, 2023
Background: Hepcidin is a 25 amino acid peptide expressed in the liver. Discovered as late as 2002, hepcidin is a master regulator of iron metabolism and is sensitive to inflammation. Chronic periodontitis, being an inflammatory condition, affects levels
Tejavathi Nagaraj, V S Vaishnavi, Holenarasipur Nagesh Santosh, Durga Okade, Pooja Sinha, J Anitha   +5 more
doaj   +1 more source