Results 71 to 80 of about 25,679 (210)

Diagnostic Lag in Precision Medicine

Clinical Pharmacology &Therapeutics, EarlyView.
Petr Heneberg
wiley   +1 more source

Porphyromonas gingivalis and Ferroptosis: Evidence, Limitations, and Significance

Cell Biochemistry and Function, Volume 44, Issue 11, November 2026.
ABSTRACT Porphyromonas gingivalis (P. gingivalis) is a keystone pathogen in periodontal dysbiosis and has been linked to multiple systemic diseases. Ferroptosis is a form of regulated cell death driven by iron‐dependent lipid peroxidation, and accumulating evidence implicates it in P. gingivalis‐associated tissue injury.
Xiaoting Fang, Xiaoyue Xu, Tingting Wei, Siyang Lu, Guili Qin, Hong Chen   +5 more
wiley   +1 more source

Iron, hepcidin, and the metal connection [PDF]

Frontiers in Pharmacology, 2014
Identification of new players in iron metabolism, such as hepcidin, which regulates ferroportin and divalent metal transporter 1 expression, has improved our knowledge of iron metabolism and iron-related diseases. However, from both experimental data and clinical findings, "iron-related proteins" appear to also be involved in the metabolism of other ...
Olivier eLoréal, Olivier eLoréal, Olivier eLoréal, Thibault eCavey, Thibault eCavey, Thibault eCavey, Edouard eBardou-Jacquet, Edouard eBardou-Jacquet, Edouard eBardou-Jacquet, Pascal eGuggenbuhl, Pascal eGuggenbuhl, Pascal eGuggenbuhl, Martine eRopert, Martine eRopert, Martine eRopert, Pierre eBrissot, Pierre eBrissot, Pierre eBrissot   +17 more
openaire   +3 more sources

Copper(II) binding properties of hepcidin [PDF]

, 2016
Hepcidin is a peptide hormone that regulates the homeostasis of iron metabolism. The N-terminal domain of hepcidin is conserved amongst a range of species and is capable of binding CuII and NiII through the amino terminal copper–nickel binding motif ...
Bansal, Sukhvinder, Kulprachakarn, Kanokwan, Arno, Maria Chiara, Kanokwan Kulprachakarn, Xiaole Kong, Chen, Yu-Lin, Somdet Srichairatanakool, Srichairatanakool, Somdet, Kong, Xiaole, Yu-Lin Chen, Sukhvinder S. Bansal, Hider, Robert Charles, Robert C. Hider, Maria C. Arno, Arno, Maria Chiara; id_orcid   +14 more
core   +2 more sources

FSP1 as the convergent hub of autophagy and ubiquitination governing ferroptosis in monocrotaline‐induced pulmonary arterial hypertension

Clinical and Translational Medicine, Volume 16, Issue 11, November 2026.
Background: The crosstalk between autophagy and ferroptosis in pulmonary arterial hypertension (PAH) remains unclear. We investigated the role of FSP1 as a critical link between these processes. Methods and Findings: Mechanistically, we identified that FSP1 degradation is dually regulated by NBR1‐mediated autophagic flux and RNFT1‐dependent K63‐linked ...
Dandan Chen, Qi Jin, Lei Zhang, Wenzhi Pan, Daxin Zhou, Junbo Ge, Lihua Guan   +6 more
wiley   +1 more source

The significance of serum hepcidin on iron status in overweight and obese patients with iron-deficiency anemia

Iraqi Journal of Hematology, 2020
BACKGROUND: Deficiency of iron is one of the most prevalent nutritional disorders, and obesity is an increasing nutritional problem, but only a few studies mention a possible association between them in Iraq.
Abeer Anwer Ahmed
doaj   +1 more source

Differential recovery of macrophage iron deficiency by oral iron formulations determines inflammation and autocrine hepcidin production in iron‐deficiency anemia

HemaSphere, Volume 10, Issue 11, November 2026.
Abstract Exposure of macrophages to iron has been implicated in sterile inflammation through reactive oxygen species (ROS)‐dependent cell pro‐inflammatory activation. Here, we compare the effect of the commonly used oral iron salt, iron sulfate (FeSO4), with that of an innovative formulation, sucrosomial® iron (SI), on the iron status and inflammatory ...
Ada Antypiuk, Michela Asperti, Richa Sharma, Shobana Navaneethabalakrishnan, Navdeep Jhita, Quentinn Pearce, James E. Cox, Elisa Brilli, Germano Tarantino, Francesca Vinchi   +9 more
wiley   +1 more source

Association Between Deep Gray Matter Iron Deposition Dysregulation and Cognitive Performance in Type 2 Diabetes Mellitus Patients: A Quantitative Susceptibility Mapping Study

Journal of Magnetic Resonance Imaging, Volume 64, Issue 5, Page 1295-1308, November 2026.
ABSTRACT Background Type 2 diabetes (T2DM) heightens cognitive impairment risk, yet the mechanisms remain unclear. Hyperglycemia‐induced iron dysregulation in deep gray matter (DGM) nuclei may be a crucial mechanism. Purpose To investigate DGM iron deposition in T2DM using Quantitative Susceptibility Mapping (QSM) and determine its association with ...
Kun Wang, Jiahe Wang, Ziyu Diao, Xin Tan, Shijun Qiu, Jie An   +5 more
wiley   +1 more source

Model correctly predicts responses to perturbations in the SMAD4-hepcidin-pathway as well as development of anemia under chronic inflammation.

, 2017
A-Model quantitatively predicts experimentally measured responses for 2 months old C326S knock-in mice expressing a hepcidin-resistant FPN mutant or or SMAD4-knockout mice. The model simulations are shown as blue bars and the corresponding data from [37]
Mihaela Enculescu (3626096), Maximilian Hahnel (3626093), Stefan Legewie (65841), Martina U. Muckenthaler (156534), Johannes Bode (3424313), Christoph Metzendorf (3626090), Richard Sparla (3626087)   +6 more
core   +1 more source

Subcutaneous Adipose Tissue from Obese and Lean Adults Does Not Release Hepcidin In Vivo

The Scientific World Journal, 2011
Hepcidin is the main regulator of systemic iron homeostasis and is primarily produced by the liver but is also expressed, at the mRNA-level, in periphery tissues including the subcutaneous and visceral adipose tissue.
Lisa Tussing-Humphreys, Keith N. Frayn, Steven R. Smith, Mark Westerman, A. Louise Dennis, Elizabeta Nemeth, Jessica Thomson, Cenk Pusatcioglu   +7 more
doaj   +1 more source