Results 71 to 80 of about 30,077 (251)

Hepcidin: Regulation of the master iron regulator [PDF]

, 2015
Iron, an essential nutrient, is required for many diverse biological processes. The absence of a defined pathway to excrete excess iron makes it essential for the body to regulate the amount of iron absorbed; a deficiency could lead to iron deficiency ...
Wallace, Daniel F., Wallace, D.F., Subramaniam, V. Nathan, V. Nathan Subramaniam, Daniel F. Wallace, Gautam Rishi, Rishi, Gautam, Rishi, G., Subramaniam, V.N.   +8 more
core   +1 more source

Interplay of serum hepcidin with female sex hormones, metabolic syndrome, and abdominal fat distribution among premenopausal and postmenopausal women

The Egyptian Journal of Internal Medicine, 2022
Highlights • Postmenopausal state (PMS) and metabolic syndrome (MetS) are independent factors of high hepcidin. • Estrogen and progesterone are correlated with hepcidin but not explain its higher level in PMS. • Ferritin, insulin resistance, and MetS are
Ragaa Abdelshaheed Matta, Mohamed Emad AbdElftah, Mohamed Gaber Essawy, Ahmed Abdelfadel Saedii   +3 more
doaj   +1 more source

Impact of Hemoglobin Improvement on Survival in Patients With Myelofibrosis and Anemia Treated With Momelotinib in the SIMPLIFY‐1 and MOMENTUM Trials

European Journal of Haematology, EarlyView.
In this post hoc analysis of the phase 3 SIMPLIFY‐1 and MOMENTUM trials, the number of patients with baseline hemoglobin < 10 g/dL who achieved hemoglobin ≥ 10 g/dL by week 24 with momelotinib, as well as the time to achievement, were evaluated. Patients who were JAK inhibitor naive and/or had moderate anemia were more likely and faster to achieve this
Francesca Palandri, Casey O'Connell, Pankit Vachhani, Donal P. McLornan, Steffen Koschmieder, Juan Carlos Hernandez‐Boluda, Kazuya Shimoda, Shiyuan Zhang, Catherine Ellis, Jessica Lim, Jasmine Sahni, Vikas Gupta   +11 more
wiley   +1 more source

Regulation of hepcidin and hemojuvelin expression and their role in iron homeostasis [PDF]

, 2010
Hepcidin is the key regulator of iron homeostasis acting as a negative regulator of intestinal iron absorption. Several proteins have recently been identified to act as upstream regulators of hepcidin expression, such as HFE and hemojuvelin (HJV ...
Salama, M.F.I.
core  

Safety and Efficacy of Iron Chelators in Patients With Chronic Kidney Disease: A Systematic Review and Meta‐Analysis

Hemodialysis International, EarlyView.
ABSTRACT Background Iron overload in chronic kidney disease contributes to oxidative injury. The role of iron chelators, standard in transfusion‐related overload, remains unclear in chronic kidney disease. Aim To evaluate the efficacy and safety of iron chelators in adults with chronic kidney disease.
Humam Emad Rajha, Richard Shamoon, Ameer Almeshagbeh, Samah Masry, Fadel Alqatati, Baha H. Abuajameia, Abdulqadir J. Nashwan   +6 more
wiley   +1 more source

Iron, hepcidin, and the metal connection [PDF]

Frontiers in Pharmacology, 2014
Identification of new players in iron metabolism, such as hepcidin, which regulates ferroportin and divalent metal transporter 1 expression, has improved our knowledge of iron metabolism and iron-related diseases. However, from both experimental data and clinical findings, "iron-related proteins" appear to also be involved in the metabolism of other ...
Olivier eLoréal, Olivier eLoréal, Olivier eLoréal, Thibault eCavey, Thibault eCavey, Thibault eCavey, Edouard eBardou-Jacquet, Edouard eBardou-Jacquet, Edouard eBardou-Jacquet, Pascal eGuggenbuhl, Pascal eGuggenbuhl, Pascal eGuggenbuhl, Martine eRopert, Martine eRopert, Martine eRopert, Pierre eBrissot, Pierre eBrissot, Pierre eBrissot   +17 more
openaire   +3 more sources

Development of a mass spectrometry diagnostic assay to monitor hepcidin levels in hemochromatosis patients [PDF]

, 2010
Hepcidin has been identified as the principle regulatory peptide essential for iron homeostasis. Expression of this cysteine-rich peptide is up-regulated by inflammation and iron overload, whereas hypoxia, iron deficiency and erythropoiesis suppress ...
Gay, Choon Lin Melvin
core  

The significance of serum hepcidin on iron status in overweight and obese patients with iron-deficiency anemia

Iraqi Journal of Hematology, 2020
BACKGROUND: Deficiency of iron is one of the most prevalent nutritional disorders, and obesity is an increasing nutritional problem, but only a few studies mention a possible association between them in Iraq.
Abeer Anwer Ahmed
doaj   +1 more source

Diagnostic Lag in Precision Medicine

Clinical Pharmacology &Therapeutics, EarlyView.
Petr Heneberg
wiley   +1 more source

Dietary modulation of antimicrobial peptides (HAMP and LEAP2) in Chinook salmon (Oncorhynchus tshawytscha) fed a phytobiotic functional diet: Integrated genomic characterisation and tissue‐specific expression

Journal of Fish Biology, EarlyView.
Abstract Antimicrobial peptides (AMPs) are key components of the innate immune system in fish, providing rapid protection against microbial pathogens. Among these, the liver‐expressed antimicrobial peptides (LEAPs), comprising LEAP‐1 (hepcidin; HAMP) and LEAP‐2, play central roles in host defence and iron regulation.
Roberta Marcoli, Jane E. Symonds, Seumas P. Walker, Cesar Lopez, Mark A. Preece, Christopher Battershill, Steve Bird   +6 more
wiley   +1 more source