Results 91 to 100 of about 30,077 (251)

Serum hepcidin levels in multiple sclerosis

Multiple Sclerosis Journal - Experimental, Translational and Clinical, 2019
Background Brain iron accumulation is associated with multiple sclerosis (MS). Hepcidin is the master regulator of iron homeostasis and distribution.
Gabriel Bsteh, David Haschka, Piotr Tymoszuk, Klaus Berek, Verena Petzer, Harald Hegen, Sebastian Wurth, Michael Auer, Anne Zinganell, Franziska Di Pauli, Florian Deisenhammer, Guenter Weiss, Thomas Berger   +12 more
doaj   +1 more source

Mechanisms of Thrombocytosis in Iron‐Deficiency Anemia

European Journal of Haematology, Volume 117, Issue 4, Page 728-738, October 2026.
ABSTRACT Iron‐deficiency anemia is frequently accompanied by reactive thrombocytosis, yet the mechanisms underlying this association remain incompletely understood. Beyond impaired erythropoiesis, iron availability has emerged as an active regulator of hematopoietic lineage decisions.
João Vitor Facco, Diane S. Krause, Sara T. Olalla Saad   +2 more
wiley   +1 more source

Regulators of hepcidin expression

, 2019
Iron, an essential nutrient, is required for many biological processes but is also toxic in excess. The lack of a mechanism to excrete excess iron makes it crucial for the body to regulate the amount of iron absorbed from the diet. This regulation is mediated by the hepatic hormone hepcidin.
Roth, Marie-Paule, Meynard, Delphine, Coppin, Hélène   +2 more
openaire   +4 more sources

Model correctly predicts responses to perturbations in the SMAD4-hepcidin-pathway as well as development of anemia under chronic inflammation.

, 2017
A-Model quantitatively predicts experimentally measured responses for 2 months old C326S knock-in mice expressing a hepcidin-resistant FPN mutant or or SMAD4-knockout mice. The model simulations are shown as blue bars and the corresponding data from [37]
Mihaela Enculescu (3626096), Maximilian Hahnel (3626093), Stefan Legewie (65841), Martina U. Muckenthaler (156534), Johannes Bode (3424313), Christoph Metzendorf (3626090), Richard Sparla (3626087)   +6 more
core   +1 more source

Expression of hepcidin mRNA is uniformly suppressed in hepatocellular carcinoma

BMC Cancer, 2008
Background The present study evaluated the expression of hepcidin mRNA in hepatocellular carcinoma (HCC). Methods Samples of cancerous and non-cancerous liver tissue were taken from 40 patients with HCC who underwent hepatectomy.
Tomosugi Naohisa, Sawada Tokihiko, Kijima Hiroaki, Kubota Keiichi   +3 more
doaj   +1 more source

NFкB pathway suppression as a key driver of pacritinib response in high‐risk myelofibrosis

British Journal of Haematology, EarlyView.
R. Van Dijck, M. ter Borg, B. van der Holt, A. E. C. Broers, M. D. Hazenberg, J. J. Cornelissen, N. P. M. Schaap, E. de Pater, P. A. W. te Boekhorst   +8 more
wiley   +1 more source

Low Carbohydrate Availability in Energy Balance Alters Bone Turnover and Muscle Proteomic Response With Limited Endocrine Disruption

The FASEB Journal, Volume 40, Issue 17, 15 September 2026.
Eight trained males completed 4 days of normal‐carbohydrate or low‐carbohydrate (81% reduction in carbohydrate) diets while maintaining energy balance and undertaking daily exercise. Low carbohydrate decreased total body water and fat‐free mass, increased circulating free fatty acids, glycerol and β‐hydroxybutyrate, alongside increased fat oxidation at
Erick Mosquera‐Lopez, Harry L. Taylor, Yusuke Nishimura, Carl Langan‐Evans, Sam O. Shepherd, Juliette A. Strauss, James P. Morton, Jatin G. Burniston, Jose L. Areta   +8 more
wiley   +1 more source

Hepcidin-mediated Fpn control and inhibition of Fpn transcription contribute to the acute inflammatory response.

, 2017
A-Experimental data (means with standard deviation) and simulated data (lines) for serum iron content following peritoneal injection of LPS for mice maintained on a standard or iron-enriched diet.
Mihaela Enculescu (3626096), Maximilian Hahnel (3626093), Stefan Legewie (65841), Martina U. Muckenthaler (156534), Johannes Bode (3424313), Christoph Metzendorf (3626090), Richard Sparla (3626087)   +6 more
core   +1 more source

Materials‐Guided Gene‐Ionizable Lipid Nanoparticles to Reverse Iron‐Associated Immune Resistance in Renal Cancer

Advanced Science, Volume 13, Issue 49, 3 September 2026.
ABSTRACT Iron overload is a common metabolic disturbance in cancer and contributes to poor outcomes in renal cell carcinoma (RCC), yet its effects on the tumour immune microenvironment remain unclear. Here we identify a previously unrecognized immunosuppressive axis in which iron overload downregulates the palmitoyltransferase ZDHHC12 in CD8+ T cells ...
Xin Jin, Yulong Hong, Chengliang Yin, Wanyang Guo, Yaxuan Wang, Ruijiang Zeng, Ruilin Liu, Zexian Ding, Xinlin Liu, Shangqing Ren, Qiyang Liang, Yaohui Wang, Xu Zhang, João Conde, Yuan Li, Xin Ma, Liangyou Gu   +16 more
wiley   +1 more source

Modelling of a metal-containing hepcidin

, 2006
Hepcidin was originally identified as a liver-expressed antimicrobial peptide but further studies have shown that it also has a key role in iron homeostasis.
Evans, Robert, Evans, R.W., Farnaud, S., Patel, A.   +3 more
core   +1 more source