Results 111 to 120 of about 30,077 (251)

Lcn2 Promotes Ferroptosis in Intracerebral Hemorrhage by Targeting Keap1 Tyr572 and Restricting Nrf2 Activation

MedComm, Volume 7, Issue 9, September 2026.
This study reveals that Lcn2 regulates ferroptosis after ICH via the Keap1/Nrf2 axis. Neuronal Lcn2 deletion reduces lipid peroxidation, restores mitochondrial function, and improves ferroptosis. Keap1 Tyr572Ala mutant acts as a molecular switch whose effects invert with Lcn2 status.
Ya‐nan Dou, Hongkang Hu, Qinghua Li, Guangming Wang, Lijun Hou, Junbin Liu, Buyi Zheng, Ying Li, Guohan Hu, Zhou Fei, Xia Li, Li Wang, Jialiang Wei, Lei Jiang, Xiaowei Fei   +14 more
wiley   +1 more source

Ferroptosis: Newly Emerged Regulator for Human Disease

MedComm, Volume 7, Issue 9, September 2026.
Ferroptosis is a key regulated cell death pathway closely involved in cancers, neurodegenerative disorders, acute organ injuries, and cardiovascular and chronic metabolic diseases, representing a promising therapeutic target for diverse human illnesses.
Dandan Xiao, Lin Ye, Tianqi Jiang, Mengyuan Liu, Yuxia Zhou   +4 more
wiley   +1 more source

Hepcidin Expression in Psoriasis Patients

Indian Journal of Dermatology, 2014
Background: Iron is an essential nutrient for mammals. Accelerated loss of nutrients through hyperproliferation and desquamation from the skin in psoriasis is known. Hepcidin is an important and recently discovered regulator of iron homeostasis.
Nursel Dilek, Aziz Ramazan Dilek, Kazim Şahin, Neşe Kaklikkaya, Yunus Saral   +4 more
openaire   +3 more sources

Manipulation of the hepcidin pathway for therapeutic purposes

Haematologica, 2013
Hepcidin, the liver-produced peptide hormone, is a principal regulator of iron homeostasis. Abnormal hepcidin production has emerged as a causative factor in several common iron disorders.
Eileen Fung, Elizabeta Nemeth
doaj   +1 more source

Iron Phenotypes and Reports of Menses, Pregnancies, and Live Births in Females With HFE p.C282Y Homozygosity and HFE wt/wt: A Cross‐Sectional Study

Reproductive, Female and Child Health, Volume 5, Issue 3, September 2026.
ABSTRACT Objective To compare iron phenotypes and questionnaire reports about menses, pregnancies, and live births in females with HFE p.C282Y (rs1800562) homozygosity (Y/Y) and HFE wt/wt (absence of p.C282Y and p.H63D (rs1799945) (wt/wt)). Methods We compared post‐screening iron phenotypes and questionnaire reports of self‐identified non‐Hispanic ...
James C. Barton, J. Clayborn Barton, Ronald T. Acton   +2 more
wiley   +1 more source

Hepcidin is decreased in TFR2 hemochromatosis

Blood, 2005
Abstract The hepatic peptide hepcidin is the key regulator of iron metabolism in mammals. Recent evidence indicates that certain forms of hereditary hemochromatosis are caused by hepcidin deficiency. Juvenile hemochromatosis is associated with hepcidin or hemojuvelin mutations, and these patients have low or absent urinary hepcidin ...
Nemeth E, ROETTO, Antonella, Garozzo G, Ganz T, Camaschella C.   +4 more
openaire   +4 more sources

Decoding the Black Box of Fish Vaccines Efficacy in Basic and Applied Contexts

Reviews in Aquaculture, Volume 18, Issue 4, September 2026.
ABSTRACT Vaccines are the frontline defense in aquaculture, yet predicting their real‐world performance remains a tricky puzzle. Unlike terrestrial veterinary vaccines, fish vaccines largely operate through “Black Box” processes, where we observe the outcomes but rarely understand the underlying immune mechanisms. Laboratory trials, though informative,
Jiří Kyslík, Mikolaj Adamek, Tomáš Korytář   +2 more
wiley   +1 more source

Hepcidin Plays a Key Role in 6-OHDA Induced Iron Overload and Apoptotic Cell Death in a Cell Culture Model of Parkinson’s Disease

Parkinson's Disease, 2016
Background. Elevated brain iron levels have been implicated in the pathogenesis of Parkinson’s disease (PD). However, the precise mechanism underlying abnormal iron accumulation in PD is not clear.
Qi Xu, Anumantha G. Kanthasamy, Huajun Jin, Manju B. Reddy   +3 more
doaj   +1 more source

Serum Hepcidin-25: A Predictor Of Response To Oral Iron Therapy.

Pakistan Journal of Medicine and Dentistry
Background: Discovery of hepcidin, and its receptor in year 2000 has revolutionized iron metabolism studies. Measurement of serum hepcidin, may supplement existing investigational parameters of iron status in anemias.
Ghazala Masood Farrukh, Adnan Zubairi, Amal Kamal, Syed Tauseef Ahmed   +3 more
doaj  

The effect of blood transfusion on serum hepcidin levels in chronically transfused patients of β-thalassemia major: An observational study in a tertiary care centre in Western Maharashtra

Asian Journal of Transfusion Science
INTRODUCTION: Hepcidin is the key regulator of systemic iron homeostasis. In iron-loading anemias, hepcidin levels are regulated by opposite forces of erythropoiesis and iron overload.
Sujay Bhowmik, Amit Kumar Biswas, Ajay Kumar Baranwal, Amit Ajay Pawar, Ujjwal Dimri   +4 more
doaj   +1 more source