Results 101 to 110 of about 30,077 (251)

Therapeutic Silencing of Tmprss6 Reduces Iron‐Induced Inflammation and Prolongs Survival in MDS Mice

American Journal of Hematology, Volume 101, Issue 9, Page 2105-2122, September 2026.
ABSTRACT Myelodysplastic syndromes (MDS) are a heterogeneous group of clonal hematopoietic disorders characterized by ineffective hematopoiesis, cytopenias, and an increased risk of progression to acute myeloid leukemia (AML). Despite advances in supportive and targeted therapies, disease‐modifying interventions remain limited.
Shahla Vilcassim, Nuttanan Pholngam, Rattanawan Thubthed, Tiwaporn Nualkaew, Saovaros Svasti, Pornthip Chaichompoo, Kai Kysenius, Peter J. Crouch, Sibylle Dames, Mona Eisermann, Alberto Martinez, Ute Schaeper, Jim Vadolas, George Grigoriadis   +13 more
wiley   +1 more source

Purification and partial characterisation of recombinant human hepcidin

, 2006
Hepcidin is a liver-expressed antimicrobial and iron regulatory peptide. A number of studies have indicated that hepcidin is important for the correct regulation of body iron homeostasis. The aims of this study were to analyse the expression, trafficking
Wallace, Daniel F., Rivas, Lucy, Subramaniam, V. Nathan, Jones, Marc D., Sly, Lindsay I., Pedersen, Palle   +5 more
core   +1 more source

Preoperative RDW–Albumin Ratio as a Prognostic Biomarker in Gastric Cancer Surgery

Cancer Medicine, Volume 15, Issue 9, September 2026.
ABSTRACT Background The ratio of red blood cell distribution width (RDW) to serum albumin (RAR) combines hematologic and nutritional information from routine blood tests and has shown potential value for prognostication in several diseases. This study aimed to evaluate the prognostic significance of preoperative RAR in patients with gastric cancer ...
Xinhang Cao, Weiwei Shang, Dandan Xiao, Wei Wang, Ziyu Wang, Yangbai Sun, Yan Zhang, Mingzhe Ma   +7 more
wiley   +1 more source

Virtual single‐cell perturbation and genetic causal inference reveal CSF1R‐dependent immunometabolic communication in iron metabolism‐associated osteoarthritis

Journal of Cell Communication and Signaling, Volume 20, Issue 3, September 2026.
Integrative genetic, single‐cell, and perturbation analyses identify CSF1R as a macrophage‐centered immunometabolic signaling hub linking iron dysregulation to osteoarthritis. CSF1R‐driven monocyte–macrophage remodeling may coordinate immune activation, extracellular matrix remodeling, and cartilage degeneration, providing a potential therapeutic ...
Yue Zhou, Guohang Shen, Lijing Si, Kaiyong Wang, Yang Chen, Ruoyan Wang, Yupei Dai   +6 more
wiley   +1 more source

Hepcidin level predicts hemoglobin concentration in individuals undergoing repeated phlebotomy

Haematologica, 2013
Dietary iron absorption is regulated by hepcidin, an iron regulatory protein produced by the liver. Hepcidin production is regulated by iron stores, erythropoiesis and inflammation, but its physiology when repeated blood loss occurs has not been ...
Alan E. Mast, Karen S. Schlumpf, David J. Wright, Bryce Johnson, Simone A. Glynn, Michael P. Busch, Gordana Olbina, Mark Westerman, Elizabeta Nemeth, Tomas Ganz   +9 more
doaj   +1 more source

Structural Characteristics and Immunoregulatory Effects of Colla Corii Asini Peptides with Iron‐Chelating Capacity

Food Frontiers, Volume 7, Issue 5, September 2026.
Ejiao peptides were fractionated to iron‐chelating F2 (enriched in E‐Xn‐P motif), which restored immune function in CTX‐induced immunosuppressed mice via synergistic regulation of immunity and iron homeostasis. ABSTRACT Iron homeostasis is closely related to immune function, yet the structural basis of food‐derived peptides that modulate this iron ...
Qing‐Tao Zhan, Zi‐Wei Zhao, Jian‐Hang Cai, Xue‐Mei Ge, Shuang‐Di Chen, Xue Tang, Xue‐Ying Ma, Liu‐Ping Fan, Issoufou Amadou, Xiang‐Rong Cheng   +9 more
wiley   +1 more source

Hemojuvelin: The Hepcidin Story Continues [PDF]

Kidney and Blood Pressure Research, 2009
Hemojuvelin (HJV) is a membrane protein that is responsible for the iron overload condition known as juvenile hemochromatosis. HJV, highly expressed in the liver, skeletal muscle and heart, seems to play a role in iron absorption and release from cells and has anti-inflammatory properties.
openaire   +2 more sources

Hepcidin and Cytokines in Anaemia

Hematology, 2004
Hepcidin is a cytokine-induced antibacterial protein which is produced in the liver, circulates in the blood, and is excreted in the urine. It is a major regulator of iron balance in the intestinal mucosa, and appears to have a significant role in the pathogenesis of haemochromatosis and related disorders.
openaire   +2 more sources

RETRACTED: The Role of Ubiquitination in Hepcidin-Independent and Hepcidin-Dependent Degradation of Ferroportin

Cell Metabolism, 2011
The iron exporter ferroportin (Fpn) is essential to transfer iron from cells to plasma. Systemic iron homeostasis in vertebrates is regulated by the hepcidin-mediated internalization of Fpn. Here, we demonstrate a second route for Fpn internalization; when cytosolic iron levels are low, Fpn is internalized in a hepcidin-independent manner dependent ...
De Domenico, Ivana, Lo, Eric, Yang, Baoli, Korolnek, Tamara, Hamza, Iqbal, Ward, Diane McVey, Kaplan, Jerry   +6 more
openaire   +2 more sources

Contemporary Management of Thalassemia: A Perspective on Current Standards and the Emergence of FDA‐Approved Oral Therapy

Health Science Reports, Volume 9, Issue 9, September 2026.
ABSTRACT Background and Aims Thalassemia is an inherited hemoglobin disorder characterized by ineffective erythropoiesis, chronic anemia, and progressive multisystem complications that require lifelong management. Current treatment relies on regular red blood cell transfusions, iron chelation therapy, and supportive multidisciplinary care, while ...
Fnu Zainab, Abdul Haseeb Hasan, Muhammad Hafi Abid, Muhammad Ali Abid   +3 more
wiley   +1 more source