Results 81 to 90 of about 25,679 (210)

Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Positive hepcidin/pro-hepcidin staining in ischemic brain.

, 2013
Hepcidin/pro-hepcidin was detected by immunohistochemistry. Hepcidin/pro-hepcidin positive staining was significantly increased in cerebral cortex, hippocampus and corpus striatum of ischemic brain.
Ya-Shuo Zhao (343734), Yan-Zhong Chang (343738), Wen-Shuang Wu (343736), Hui Ding (308976), Shi-Yang Chang (343735), Xiang-Lin Duan (343739), Honglian Shi (339333), Cai-Zhen Yan (343731), Peng Yu (48605), Chen-Yang Zhao (343737)   +9 more
core   +1 more source

Improved mass spectrometry assay for plasma hepcidin: detection and characterization of a novel hepcidin isoform [PDF]

, 2013
Contains fulltext : 125929.pdf (Publisher’s version ) (Open Access)Mass spectrometry (MS)-based assays for the quantification of the iron regulatory hormone hepcidin are pivotal to discriminate between the bioactive 25-amino acid form ...
Gille Hendrik, Coby M M Laarakkers, Klaver Siem, Erwin T Wiegerinck, Harold Tjalsma, Hohlbaum, A.M., Hendrik Gille, Wiegerinck, E.T.G., Swinkels Dorine W., Swinkels, D.W., Klaver, S., Gille, H., Laarakkers, C.M., Andreas M Hohlbaum, Hendrik Gille (466748), Siem Klaver, Andreas M. Hohlbaum (226312), Coby M. M. Laarakkers (228091), Kolodziejczyk Maria, Dorine W Swinkels, Laarakkers Coby M. M., Hohlbaum Andreas M., Maria Kolodziejczyk (466747), Dorine W. Swinkels (90370), Wiegerinck Erwin T., Harold Tjalsma (90375), Siem Klaver (466746), Tjalsma, H., Kolodziejczyk, M., Tjalsma Harold, Maria Kolodziejczyk, Erwin T. Wiegerinck (151361)   +31 more
core   +2 more sources

Effects of plasma transfusion on hepcidin production in human congenital hypotransferrinemia

Haematologica, 2007
Hepcidin is the key regulator of systemic iron homeostasis. We describe the modulation of hepcidin production induced by plasma transfusions in a patient with congenital hypotransferrinemia that offers a unique model in which to study the mechanism of ...
Paola Trombini, Tiziana Coliva, Elizabeta Nemeth, Raffaella Mariani, Tomas Ganz, Andrea Biondi, Alberto Piperno   +6 more
doaj   +1 more source

NFкB pathway suppression as a key driver of pacritinib response in high‐risk myelofibrosis

British Journal of Haematology, EarlyView.
R. Van Dijck, M. ter Borg, B. van der Holt, A. E. C. Broers, M. D. Hazenberg, J. J. Cornelissen, N. P. M. Schaap, E. de Pater, P. A. W. te Boekhorst   +8 more
wiley   +1 more source

The role of iron in normal and impaired testicular function

Andrology, Volume 14, Issue 8, Page 2373-2387, November 2026.
Abstract Iron plays a critical role in testicular physiology, impacting spermatogenesis, testosterone production, and overall testicular function. Iron homeostasis is maintained through systemic and cellular regulatory mechanisms, including hepcidin‐mediated systemic iron control and the iron‐responsive element/iron regulatory protein (IRE/IRP) system ...
Aileen Harrer, Esther G. Meyron‐Holtz, Andreas Meinhardt   +2 more
wiley   +1 more source

Evidence for a lack of a direct transcriptional suppression of the iron regulatory peptide hepcidin by hypoxia-inducible factors.

PLoS ONE, 2009
BackgroundHepcidin is a major regulator of iron metabolism and plays a key role in anemia of chronic disease, reducing intestinal iron uptake and release from body iron stores.
Melanie Volke, Daniel P Gale, Ulrike Maegdefrau, Gunnar Schley, Bernd Klanke, Anja-Katrin Bosserhoff, Patrick H Maxwell, Kai-Uwe Eckardt, Christina Warnecke   +8 more
doaj   +1 more source

Impact of Hemoglobin Improvement on Survival in Patients With Myelofibrosis and Anemia Treated With Momelotinib in the SIMPLIFY‐1 and MOMENTUM Trials

European Journal of Haematology, Volume 117, Issue 5, Page 1265-1274, November 2026.
In this post hoc analysis of the phase 3 SIMPLIFY‐1 and MOMENTUM trials, the number of patients with baseline hemoglobin < 10 g/dL who achieved hemoglobin ≥ 10 g/dL by week 24 with momelotinib, as well as the time to achievement, were evaluated. Patients who were JAK inhibitor naive and/or had moderate anemia were more likely and faster to achieve this
Francesca Palandri, Casey O'Connell, Pankit Vachhani, Donal P. McLornan, Steffen Koschmieder, Juan Carlos Hernandez‐Boluda, Kazuya Shimoda, Shiyuan Zhang, Catherine Ellis, Jessica Lim, Jasmine Sahni, Vikas Gupta   +11 more
wiley   +1 more source

Purification and partial characterisation of recombinant human hepcidin

, 2006
Hepcidin is a liver-expressed antimicrobial and iron regulatory peptide. A number of studies have indicated that hepcidin is important for the correct regulation of body iron homeostasis. The aims of this study were to analyse the expression, trafficking
Wallace, Daniel F., Rivas, Lucy, Subramaniam, V. Nathan, Jones, Marc D., Sly, Lindsay I., Pedersen, Palle   +5 more
core   +1 more source

The physiology and pathophysiology of hepcidin [PDF]

, 2013
Hepcidin, the critical iron regulatory factor, is a small peptide produced by the hepatocytes in response to increased body iron and inflammation. Circulating hepcidin controls both intestinal iron absorption and the release of iron from macrophages into
Busbridge, Mark
core   +1 more source