Results 61 to 70 of about 30,077 (251)

Integrating novel therapeutic strategies in myeloproliferative neoplasms: Driving disease‐directed progress

British Journal of Haematology, EarlyView.
Summary Over the past decade, there has been a substantial increase in the diversity and number of therapeutic options for myeloproliferative neoplasms (MPNs). While many remain within the clinical trial arena, the clinician and patient community have seen more approvals reaching the clinic and a rethink on how best we should be approaching these ...
Trung Q. Ngo, Maria Georgiou, Donal P. McLornan, Claire N. Harrison   +3 more
wiley   +1 more source

An Overlooked Hepcidin–Cadmium Connection

International Journal of Molecular Sciences, 2022
Hepcidin (DTHFPICIFCCGCCHRSKCGMCCKT), an iron-regulatory hormone, is a 25-amino-acid peptide with four intramolecular disulfide bonds circulating in blood. Its hormonal activity is indirect and consists of marking ferroportin-1 (an iron exporter) for degradation.
Dawid Płonka, Marta D. Wiśniewska, Manuel D. Peris-Díaz, Artur Krężel, Arkadiusz M. Bonna, Wojciech Bal   +5 more
openaire   +2 more sources

The hepcidin‐ferroportin axis influences mitochondrial function, proliferation, and migration in pulmonary artery endothelial and smooth muscle cells

Pulmonary Circulation
Elevated circulating hepcidin levels have been reported in patients with pulmonary artery hypertension (PAH). Hepcidin has been shown to promote proliferation of human pulmonary artery smooth muscle cells (PASMCs) in vitro, suggesting a potential role in
Theo Issitt, Quezia K. Toe, Sofia L. Pedersen, Thomas Shackshaft, Maziah Mohd Ghazaly, Laura West, Nadine D. Arnold, Abdul Mahomed, George W. Kagugube, Latha Ramakrishnan, Allan Lawrie, Gregory J. Quinlan, S. John Wort   +12 more
doaj   +1 more source

Serum Hepcidin Levels and Reticulocyte Hemoglobin Concentrations as Indicators of the Iron Status of Peritoneal Dialysis Patients

International Journal of Nephrology, 2012
Hepcidin is the key mediator of renal anemia, and reliable measurement of serum hepcidin levels has been made possible by the ProteinChip system. We therefore investigated the iron status and serum hepcidin levels of peritoneal dialysis (PD) patients who
Aya Eguchi, Takahiro Mochizuki, Misao Tsukada, Koji Kataoka, Yukio Hamaguchi, Shinichiro Oguni, Kosaku Nitta, Ken Tsuchiya   +7 more
doaj   +1 more source

A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis

Haematologica, 2015
Mice have been essential for distinguishing the role of hepcidin in iron homeostasis. Currently, investigators monitor levels of murine hepatic hepcidin-1 mRNA as a surrogate marker for the bioactive hepcidin protein itself.
Patrick Gutschow, Paul J. Schmidt, Huiling Han, Vaughn Ostland, Thomas B. Bartnikas, Michael A. Pettiglio, Carolina Herrera, James S. Butler, Elizabeta Nemeth, Tomas Ganz, Mark D. Fleming, Mark Westerman   +11 more
doaj   +1 more source

Hepcidin-25 in chronic hemodialysis patients is related to residual kidney function and not to treatment with erythropoiesis stimulating agents. [PDF]

PLoS ONE, 2012
Hepcidin-25, the bioactive form of hepcidin, is a key regulator of iron homeostasis as it induces internalization and degradation of ferroportin, a cellular iron exporter on enterocytes, macrophages and hepatocytes.
Neelke C van der Weerd, Muriel P C Grooteman, Michiel L Bots, Marinus A van den Dorpel, Claire H den Hoedt, Albert H A Mazairac, Menso J Nubé, E Lars Penne, Carlo A Gaillard, Jack F M Wetzels, Erwin T Wiegerinck, Dorine W Swinkels, Peter J Blankestijn, Piet M Ter Wee, CONTRAST Investigators   +14 more
doaj   +1 more source

Hepcidin as a risk marker for cardiovascular disease in periodontitis—A case control study

Journal of Indian Academy of Oral Medicine and Radiology, 2023
Background: Hepcidin is a 25 amino acid peptide expressed in the liver. Discovered as late as 2002, hepcidin is a master regulator of iron metabolism and is sensitive to inflammation. Chronic periodontitis, being an inflammatory condition, affects levels
Tejavathi Nagaraj, V S Vaishnavi, Holenarasipur Nagesh Santosh, Durga Okade, Pooja Sinha, J Anitha   +5 more
doaj   +1 more source

Janus kinase inhibitors after ruxolitinib failure in myelofibrosis: A systematic review and pooled analysis of phase 3 efficacy and integrated safety across clinical trials and real‐world evidence

British Journal of Haematology, EarlyView.
Summary Ruxolitinib remains first‐line standard of care for symptomatic myelofibrosis, but resistance/intolerance develops in most patients. Three Janus kinase inhibitors (JAKis) have entered the post‐ruxolitinib space via distinct pivotal trials. We systematically searched prospective trials evaluating JAKi in refractory adults with myelofibrosis ...
Andrea Duminuco, Patrick Harrington, Elena Torre, Hillary Catellani, Novella Pugliese, Matteo Pacilli, Annalisa Santisi, Arianna Sbriglione, Giuseppe A. Palumbo   +8 more
wiley   +1 more source

Hepcidin.

[Rinsho ketsueki] The Japanese journal of clinical hematology, 2016
Hepcidin is an iron-regulating peptide hormone made in the liver. It controls the delivery of iron to blood plasma from intestinal cells absorbing iron, from erythrocyte-recycling macrophages, and from iron-storing hepatocytes. Hepcidin acts by binding to and inactivating the sole cellular iron exporter, ferroportin, which delivers iron to plasma from ...
openaire   +2 more sources

Increased duodenal iron uptake and transfer in a rat model of chronic hypoxia is accompanied by reduced hepcidin expression [PDF]

, 2005
Background: Despite the requirement for increased iron delivery for erythropoiesis during hypoxia, there is very little information on how duodenal iron uptake and its transfer to the blood adapts to this condition.Aims: To assess the effects of 30 days ...
Mascarenhas, M, Churchill, LJ, Debnam, ES, Leung, PS, Srai, SK   +4 more
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