Results 61 to 70 of about 25,679 (210)

Adaptation to extreme environments: A review of Antarctic fish physiology

Journal of Fish Biology, EarlyView.
Abstract Having evolved in the chronically cold and thermally stable waters of the Southern Ocean (SO) for millions of years, Antarctic fish possess a suite of physiological specializations that enable them to survive at temperatures near the freezing point of seawater. Adaptations include the evolution of antifreeze proteins, modifications of membrane
Seungyeon Lee, Sachithra Amarin Hettiarachchi, Il‐Chan Kim, Jae‐Seong Lee, Thomas Desvignes, Julia M. York, Laura Ghigliotti, Jilda Alicia Caccavo, Jin‐Hyoung Kim   +8 more
wiley   +1 more source

Iron regulation by hepcidin [PDF]

Journal of Clinical Investigation, 2013
Hepcidin is a key hormone that is involved in the control of iron homeostasis in the body. Physiologically, hepcidin is controlled by iron stores, inflammation, hypoxia, and erythropoiesis. The regulation of hepcidin expression by iron is a complex process that requires the coordination of multiple proteins, including hemojuvelin, bone morphogenetic ...
Ningning, Zhao, An-Sheng, Zhang, Caroline A, Enns   +2 more
openaire   +2 more sources

Regulation of hepcidin and hemojuvelin expression and their role in iron homeostasis [PDF]

, 2010
Hepcidin is the key regulator of iron homeostasis acting as a negative regulator of intestinal iron absorption. Several proteins have recently been identified to act as upstream regulators of hepcidin expression, such as HFE and hemojuvelin (HJV ...
Salama, M.F.I.
core  

The clinical value of plasma hepcidin levels in predicting bacterial infections in febrile children

Pediatrics and Neonatology, 2019
Background: Febrile children are often evaluated for the risk of bacterial infections in the pediatric emergency department (PER). Hepcidin is an acute phase inflammatory protein. In this study, we examined the plasma hepcidin levels in febrile children.
Jia-Huei Yan, Xin-Yuan Cai, Ying-Hsien Huang   +2 more
doaj   +1 more source

Periodontitis and metabolic dysfunction‐associated steatotic liver disease

Periodontology 2000, EarlyView.
Abstract Objective Periodontitis is a chronic inflammatory disease with systemic effects that extend beyond the oral cavity and contribute to systemic immune and metabolic dysregulation. Chronic liver diseases, particularly metabolic dysfunction‐associated steatotic liver disease (MASLD) and its progressive phenotypes, have emerged as major global ...
Rafael Scaf de Molon, Erica Dorigatti de Avila, Davi da Silva Barbirato, Mariana Fampa Fogacci, Jamil Awad Shibli, Anton Sculean, Alpdogan Kantarci   +6 more
wiley   +1 more source

Development of a mass spectrometry diagnostic assay to monitor hepcidin levels in hemochromatosis patients [PDF]

, 2010
Hepcidin has been identified as the principle regulatory peptide essential for iron homeostasis. Expression of this cysteine-rich peptide is up-regulated by inflammation and iron overload, whereas hypoxia, iron deficiency and erythropoiesis suppress ...
Gay, Choon Lin Melvin
core  

A competitive enzyme-linked immunosorbent assay specific for murine hepcidin-1: correlation with hepatic mRNA expression in established and novel models of dysregulated iron homeostasis

Haematologica, 2015
Mice have been essential for distinguishing the role of hepcidin in iron homeostasis. Currently, investigators monitor levels of murine hepatic hepcidin-1 mRNA as a surrogate marker for the bioactive hepcidin protein itself.
Patrick Gutschow, Paul J. Schmidt, Huiling Han, Vaughn Ostland, Thomas B. Bartnikas, Michael A. Pettiglio, Carolina Herrera, James S. Butler, Elizabeta Nemeth, Tomas Ganz, Mark D. Fleming, Mark Westerman   +11 more
doaj   +1 more source

Interplay of serum hepcidin with female sex hormones, metabolic syndrome, and abdominal fat distribution among premenopausal and postmenopausal women

The Egyptian Journal of Internal Medicine, 2022
Highlights • Postmenopausal state (PMS) and metabolic syndrome (MetS) are independent factors of high hepcidin. • Estrogen and progesterone are correlated with hepcidin but not explain its higher level in PMS. • Ferritin, insulin resistance, and MetS are
Ragaa Abdelshaheed Matta, Mohamed Emad AbdElftah, Mohamed Gaber Essawy, Ahmed Abdelfadel Saedii   +3 more
doaj   +1 more source

Elevated first-trimester hepcidin level is associated with reduced risk of iron deficiency anemia in late pregnancy: a prospective cohort study

Frontiers in Nutrition, 2023
BackgroundIron deficiency (ID) and iron deficiency anemia (IDA) during pregnancy are highly prevalent worldwide. Hepcidin is considered an important biomarker of iron status.
Peng Sun, Yueqin Zhou, Suhua Xu, Xiaotong Wang, Xiuxiu Li, Hailin Li, Zongyu Lin, Fenglian Huang, Lewei Zhu, Yanna Zhu   +9 more
doaj   +1 more source

Hypoxia and hypercapnia elicit overlapping but distinct skeletal muscle toxicities

The Journal of Physiology, EarlyView.
Abstract figure legend Hypoxia and hypercapnia cause overlapping skeletal muscle phenotypes, including atrophy, change in myofibre metabolic profile and myogenic response to injury. Both signals operate via distinct cellular pathways. Abstract Skeletal muscle dysfunction is strongly associated with elevated mortality in acute and chronic pulmonary ...
Joseph Balnis, Ariel Jaitovich
wiley   +1 more source