Results 161 to 170 of about 5,796,978 (304)

Cannabinoids in Cancer: Molecular Mechanisms of Tumor Cell Death and Translational Opportunities. [PDF]

Biomolecules
El Moghrabi AA, Al Khatib A, Cheikh IA, Al Hage C, Ismail D, Zhour M, Mwesigwa P, Darwiche N.   +7 more
europepmc   +1 more source

Coixenolide Enhances Antitumor Immunity of Cytotoxic CD8+ T Cells by Inhibiting S100A8/A9‐CD36 Axis in Obesity‐Associated Pancreatic Adenocarcinoma

Advanced Science, EarlyView.
Pancreatic adenocarcinoma (PAAD) remains highly lethal with limited treatment options. This study demonstrates that coixenolide, a bioactive compound from Coix lacryma‐jobi L. and a key component of the clinically approved Kanglaite injection, exhibits enhanced antitumor efficacy in high‐fat diet (HFD)‐induced obese mice bearing PAAD tumors compared to
Kaidi Chen, Rong Chen, Wei Li, Bin Song, Ruiying Zhang, Lewei Dai, Yuwei Qi, Ruqian Chen, Yifan Xu, Hangbin Li, Jingyi Huang, Fangping Wu, Jianan Peng, Xinyu Wang, Yang Xiong, Chaofeng Mu, Guilin Cheng, Zhaoshen Li, Shanming Ruan, Lei Huang, Mancang Gu   +20 more
wiley   +1 more source

Copper‐Driven Epithelial Barrier Disruption: A Novel Mechanism of COPD Acute Exacerbations Mediated by the TNF‐α/ATP7A Axis

Advanced Science, EarlyView.
This study reveals a copper‐driven mechanism of COPD acute exacerbations mediated by the TNF‐α/ATP7A axis. TNF‐α suppresses the copper transporter ATP7A via competitive NF‐κB/CREB1/CBP signaling, resulting in intracellular copper accumulation, mitochondrial oxidative stress, and epithelial barrier disruption.
Xinru Xiao, Yongzhe Hao, Ziqi Ding, Zhipeng Wang, Yujia Shi, Yanhua Huang, Chunjian Qi, Qian Zhang   +7 more
wiley   +1 more source

Dietary Fat, Inflammation, Circulating Tumor Cells, and Circulating Tumor DNA in Colorectal Cancer Survivors: An Exploratory Cross-Sectional Study. [PDF]

J Acad Nutr Diet
Compton SLE, Cho E, Spielmann G, Yi F, Yang S, Brown JC.   +5 more
europepmc   +1 more source

Synthetic Toll‐Like Receptors for Control of Innate Immunity With Far‐Red Light

Advanced Science, EarlyView.
Synthetic Toll‐like receptors (TLRs) are engineered by replacing their natural sensing regions with a far‐red‐light‐responsive module from a bacterial phytochrome. These synthetic receptors enable light‐controlled regulation of immune signaling in mammalian cells.
Anna V. Leopold, Vladislav V. Verkhusha
wiley   +1 more source

Effects of Transcranial Direct Current Stimulation Versus Sham Stimulation on Brain-Derived Neurotrophic Factor and Clinical Outcomes: A Systematic Review and Meta-Analysis. [PDF]

J Clin Med
Addas K, Aldabbagh A, Balloura J, Al Raiy A, Balafkhar RM, Othman LS, Aldowairej K, Al-Amoudi OA, Alotaibi MM, Aldehaim FM, Sibyani H, Alshahrani BM, Alnwiji A, Jasim Y, Mohamed AMA.   +14 more
europepmc   +1 more source

Phosphorylated STYK1 Promotes Gemcitabine Resistance via Autophagy‐Mediated Cancer Stemness in Pancreatic Cancer

Advanced Science, EarlyView.
Gemcitabine resistance remains a major challenge in pancreatic ductal adenocarcinoma. This study identifies STYK1 as a key mediator of chemoresistance through autophagy‐dependent maintenance of cancer stemness. Gemcitabine‐activated AMPK phosphorylates STYK1 at Ser91 and Ser304, enhancing autophagy and stemness.
Xueying Dong, Shi Li, Chensong Huang, Xuehong Qian, Jieyu Guo, Yahao Guo, Guifang Wu, Qi Zhang, Hongfei Tan, Yu Han, Rui Zhang, Hao Lyu, Shuai Xiao, Dong Guo, Chaojun Yan, Wenying Qin, Changchun Li, Xing‐Zhen Chen, Ying Zhao, Cefan Zhou, Jingfeng Tang   +20 more
wiley   +1 more source

Necroptosis: The Regulation Between EGFR and TNFR in Cancer. [PDF]

Cells
Kim JG, Jin W.
europepmc   +1 more source

Polymorphism of the tumor necrosis factor region in relation to disease [PDF]

, 1992
Linden, Sjef M. van der, Messer, Gerald, Kijlstra, Aize, Weiss, Elisabeth H., Verjans, Georges M.   +4 more
core   +1 more source

Tumor necrosis factor and tumor necrosis factor receptors in coelacanth genes [PDF]

Protein superfamilies incorporate any of a group of proteins having similar structure and functionality which descend from the same ancestral gene. The Tumer Necrosis Factor, TNF, and Tumor Necrosis Factor Receptors, TNFR, were investigated by utilizing ...

core