Results 11 to 20 of about 10,420,356 (335)

Vascular endothelial growth factor can signal through platelet-derived growth factor receptors

Journal of Cell Biology, 2007
Vascular endothelial growth factor (VEGF-A) is a crucial stimulator of vascular cell migration and proliferation. Using bone marrow–derived human adult mesenchymal stem cells (MSCs) that did not express VEGF receptors, we provide evidence that VEGF-A can
Cay M Kielty, Stephen G Ball, C Adrian Shuttleworth   +2 more
exaly   +2 more sources

Signal transduction by vascular endothelial growth factor receptors. [PDF]

Cold Spring Harbor Perspectives in Medicine, 2012
Vascular endothelial growth factors (VEGFs) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in the adult. It is therefore important to understand the mechanism of action of this family of five mammalian ligands, which act through three receptor tyrosine kinases (RTKs).
S. Koch, L. Claesson-Welsh
semanticscholar   +3 more sources

Characterization of the receptors for vascular endothelial growth factor.

Journal of Biological Chemistry, 1990
Vascular endothelial growth factor (vEGF) is a recently discovered mitogen for endothelial cells. It is also a potent angiogenic factor. We have characterized the vEGF receptors of endothelial cells using both binding and cross-linking techniques ...
N. Vaĭsman, D. Gospodarowicz, G. Neufeld   +2 more
semanticscholar   +3 more sources

Characterization of therapeutic antibodies targeting lymphatic and vascular resistance factor for the treatment of hypervascularized and highly metastatic cancers. [PDF]

Mol Oncol
LVRF (lymphatic and vascular resistance factor) is a VEGFA splice variant upregulated in response to anti‐angiogenic therapy that fosters tumor adaptation through enhanced vascularization, lymphangiogenesis, and metastatic dissemination. Targeting LVRF with fully human neutralizing antibodies disrupts these processes and limits resistant tumor growth ...
David M, Karaulic A, Bennetot A, Fournier C, Odet Q, Gouraud A, Bourget I, Gaggioli C, Giuliano S, Luciano F, Léger O, Sellam Z, Pagès G.   +12 more
europepmc   +2 more sources

Vascular Targeted Agents for the Treatment of Angiosarcoma [PDF]

, 2013
Background: Angiogenesis is the process of new blood vessel formation, and is regulated by angiogenic growth factors including vascular endothelial growth factor (VEGF). Angiosarcomas are rare, aggressive vascular tumours.
P J Woll (16226153), R J Young (13425891), C A Staton (16226156), Malcolm Reed (4465876), Young, Robin, N J Brown (13424178)   +5 more
core   +5 more sources

Signal transduction by vascular endothelial growth factor receptors.

Biochemical Journal, 2011
VEGFs (vascular endothelial growth factors) control vascular development during embryogenesis and the function of blood vessels and lymphatic vessels in the adult. There are five related mammalian ligands, which act through three receptor tyrosine kinases. Signalling is modulated through neuropilins, which act as VEGF co-receptors.
S. Koch, S. Tugues, Xiu-Juan Li, Laura Gualandi, L. Claesson-Welsh   +4 more
semanticscholar   +3 more sources

Vasoregulatory Autoantibodies and Clinical Outcome After Ischemic Stroke—PROSCIS‐B

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2023
Background Vasoregulatory autoantibodies including autoantibodies targeting G‐protein–coupled receptors might play a functional role in vascular diseases.
Thomas G. Liman, Bob Siegerink, Sophie Piper, Rusan Catar, Guido Moll, Gabriela Riemekasten, Harald Heidecke, Peter U. Heuschmann, Mitchell S. V. Elkind, Duska Dragun, Matthias Endres   +10 more
doaj   +1 more source

Signal transduction by vascular endothelial growth factor receptors.

Biochemical Society Transactions, 2001
Vascular endothelial growth factor (VEGF)/vascular permeability factor is the prototype for a growing family of dimeric growth factors, which exert their effects on vascular and lymphatic endothelial cells, as well as on a wide range of other cell types.
L. Claesson-Welsh
semanticscholar   +3 more sources

Melatonin ameliorates microvessel abnormalities in the cerebral cortex and hippocampus in a rat model of Alzheimer’s disease

Neural Regeneration Research, 2021
Melatonin can attenuate cardiac microvascular ischemia/reperfusion injury, but it remains unclear whether melatonin can also ameliorate cerebral microvascular abnormalities.
Pan Wang, Hai-Juan Sui, Xiao-Jia Li, Li-Na Bai, Jing Bi, Hong Lai   +5 more
doaj   +1 more source

Molecular Targeting of Epidermal Growth Factor Receptor (EGFR) and Vascular Endothelial Growth Factor Receptor (VEGFR)

Molecules, 2021
Epidermal growth factor receptor (EGFR) and vascular endothelial growth factor receptor (VEGFR) are two extensively studied membrane-bound receptor tyrosine kinase proteins that are frequently overexpressed in many cancers.
Nichole E. M. Kaufman, S. Dhingra, S. Jois, Maria da Graça H. Vicente   +3 more
semanticscholar   +1 more source