Results 11 to 20 of about 210,619 (269)

Exercise Training Ameliorates The Tramadol-Induced Toxicity on VEGF/VEGFRs/PI3K/AKT Signaling Pathway in Testicular Tissue after Tramadol Withdrawal [PDF]

International Journal of Fertility and Sterility
Background: The study investigated how exercise training protocols (ETPs) with different intensities can amelioratethe tramadol (TRA)-induced toxicity in the testicular tissue by upregulating VEGF/VEGFRs/PI3K/AKT signalingpathway in the post-withdrawal ...
Vahid Saeidifard, Asghar Tofighi, Javad Tolouei Azar, Mazdak Razi   +3 more
doaj   +1 more source

Extrahepatic Angiogenesis: A Potential Common Pathophysiological Basis of Multiple Organ Dysfunction in Rats with Cholestasis Cirrhosis

Frontiers in Bioscience-Landmark, 2023
Background: In addition to intrahepatic angiogenesis, patients with cholestasis cirrhosis develop extrahepatic vasculature disorders and functional disturbances of multiple organ systems.
Dandan Wang, Chunyong Yang, Ziyang Zeng, Xianfeng Wu, Hao Liang, Xiaoyan Hu, Yizhu Sun, Junhong Li, Jun Li, Xin Shu, Zhiyong Yang, Xiaobo Wang, Karine Belguise, Yujie Li, Bin Yi   +14 more
doaj   +1 more source

Efficacy and safety of nintedanib in patients with non-small cell lung cancer, and novel insights in radiation-induced lung toxicity

Frontiers in Oncology, 2023
Nintedanib is a tyrosine kinase inhibitor of fibroblast growth factor-, vascular endothelial growth factor-, and platelet-derived growth factor receptors.
Shu Yan, Shuyu Xue, Tiantian Wang, Ruihang Gao, Hanqiao Zeng, Qianmeng Wang, Xiaojing Jia   +6 more
doaj   +1 more source

Signal Transduction by Vascular Endothelial Growth Factor Receptors [PDF]

Cold Spring Harbor Perspectives in Medicine, 2012
Vascular endothelial growth factors (VEGFs) are master regulators of vascular development and of blood and lymphatic vessel function during health and disease in the adult. It is therefore important to understand the mechanism of action of this family of five mammalian ligands, which act through three receptor tyrosine kinases (RTKs).
Sina, Koch, Lena, Claesson-Welsh
openaire   +2 more sources

Recent advances in ocular drug delivery systems and targeting VEGF receptors for management of ocular angiogenesis: A comprehensive review

Future Journal of Pharmaceutical Sciences, 2021
Background Angiogenic ocular diseases address the main source of vision impairment or irreversible vision loss. The angiogenesis process depends on the balance between the pro-angiogenic and anti-angiogenic factors.
Soumya Narayana, Mohammed Gulzar Ahmed, B. H. Jaswanth Gowda, Pallavi K. Shetty, Arfa Nasrine, M. Thriveni, Nadira Noushida, A. Sanjana   +7 more
doaj   +1 more source

Vascular Endothelial Growth Factor Increases Urokinase Receptor Expression in Vascular Endothelial Cells [PDF]

Journal of Biological Chemistry, 1995
Vascular endothelial growth factor (VEGF) is a potent angiogenic factor and endothelial cell-specific mitogen that stimulates urokinase-type plasminogen activator (uPA) activity in vascular endothelial cells. Here, we report that VEGF increases the high affinity binding of uPA to the same cells and that this binding is prevented by a peptide ...
Mandriota, Stephano J., Seghezzi, Graziano, Vassalli, Jean-Dominique, Ferrara, Napoleone, Wasi, Safia, Mazzieri, Roberta, Mignatti, Paolo, Pepper, Michael S.   +7 more
openaire   +7 more sources

Potential mechanisms involved on how systemic IgG antibodies specific to vascular endothelial growth factor (VEGF) and induced by active immunotherapy decrease platelet derived free-VEGF

Platelets, 2022
CIGB-247 is a vascular endothelial growth factor (VEGF)-based active immunotherapy and it is currently under investigation for cancer treatment. This specific active immunotherapy encompasses two vaccine candidates that use a human VEGF variant molecule ...
Javier Sánchez Ramírez, Yanelys Morera Díaz, Mónica Bequet-Romero, Marta Ayala Ávila   +3 more
doaj   +1 more source

Vascular Endothelial Growth Factor Ligands and Receptors in Breast Cancer

Journal of Clinical Medicine, 2023
Breast cancer (BC) is the most common malignancy responsible for the largest number of deaths in women worldwide. The risk of developing BC is predisposed by many factors such as age, presence of genetic mutations or body weight. The diagnosis is mostly made relatively late, which is why patients are exposed to radical surgical treatments, long-term ...
Klaudia Katarzyna Brogowska, Monika Zajkowska, Barbara Mroczko   +2 more
openaire   +2 more sources

Expression of Hypoxia-inducible factor 1-α and Vascular endothelial growth factor-C in locally advanced breast cancer patients

Clinics, 2011
BACKGROUND: Locally advanced breast cancers are more prevalent in underdeveloped countries. Targeted therapy has been improved to identify hallmarks that are specific to these subtypes of tumors.
Luiz Gustavo Oliveira Brito, Viviane Fernandes Schiavon, Jurandyr Moreira de Andrade, Daniel Guimarães Tiezzi, Fernanda Maris Peria, Heitor Ricardo Cosiski Marana   +5 more
doaj   +1 more source

Pigment Epithelial‐Derived Factor Deficiency Accelerates Atherosclerosis Development via Promoting Endothelial Fatty Acid Uptake in Mice With Hyperlipidemia

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2019
Background Endothelial cell injury, induced by dyslipidemia, is the initiation of atherosclerosis, resulting in an imbalance in endothelial fatty acid (FA) transport. Pigment epithelial‐derived factor (PEDF) is an important regulator in lipid metabolism.
Haiping Wang, Yanfang Yang, Ming Yang, Xinghui Li, Jing Tan, Yandi Wu, Yuling Zhang, Yuanlong Li, Bo Hu, Shijie Deng, Fengmin Yang, Saifei Gao, Hui Li, Zhenyu Yang, Hui Chen, Weibin Cai   +15 more
doaj   +1 more source