Results 21 to 30 of about 210,619 (269)

Pancreatic carcinoma cells express neuropilins and vascular endothelial growth factor, but not vascular endothelial growth factor receptors [PDF]

Cancer, 2004
AbstractBACKGROUNDNeuropilins (NRPs) are characterized as coreceptors of vascular endothelial growth factor (VEGF). In the current study, the authors assessed the expression of NRPs, VEGF, and vascular endothelial growth factor receptors (VEGFRs), as well as VEGF‐induced cell proliferation, in pancreatic carcinoma cell lines and tissue specimens ...
Min, Li, Hui, Yang, Hong, Chai, William E, Fisher, Xiaoping, Wang, F Charles, Brunicardi, Qizhi, Yao, Changyi, Chen   +7 more
openaire   +2 more sources

Recent developments in receptor tyrosine kinases targeted anticancer therapy [PDF]

Veterinary World, 2016
Novel concepts and understanding of receptors lead to discoveries and optimization of many small molecules and antibodies as anti-cancerous drugs. Receptor tyrosine kinases (RTKs) are such a promising class of receptors under the investigation in past ...
Samir H. Raval , Ratn D. Singh , Dilip V. Joshi , Hitesh B. Patel , Shailesh K. Mody   +4 more
doaj   +1 more source

Ablation of angiotensin type 2 receptor prevents endothelial nitric oxide synthase glutathionylation and nitration in ischaemic abductor muscle of diabetic mice

Diabetes & Vascular Disease Research, 2020
Peripheral artery disease is a severe complication of diabetes. We have reported that the deletion of angiotensin type 2 receptor in diabetic mice promoted vascular angiogenesis in the ischaemic muscle 4 weeks following ischaemia.
Stéphanie Robillard, Clément Mercier, Valérie Breton, Judith Paquin-Veillette, Andréanne Guay, Farah Lizotte, Pedro Geraldes   +6 more
doaj   +1 more source

Galectin-3 Enhances Vascular Endothelial Growth Factor-A Receptor 2 Activity in the Presence of Vascular Endothelial Growth Factor [PDF]

Frontiers in Cell and Developmental Biology, 2021
Galectin-3 (Gal3) is a carbohydrate-binding protein reported to promote angiogenesis by influencing vascular endothelial growth factor-A receptor 2 (VEGFR2) signal transduction. Here we evaluated whether the ability of Gal3 to function as an angiogenic factor involved vascular endothelial growth factor (VEGF).
Issahy Cano, Issahy Cano, Zhengping Hu, Zhengping Hu, Dina B. AbuSamra, Dina B. AbuSamra, Magali Saint-Geniez, Magali Saint-Geniez, Yin Shan Eric Ng, Yin Shan Eric Ng, Pablo Argüeso, Pablo Argüeso, Patricia A. D’Amore, Patricia A. D’Amore, Patricia A. D’Amore   +14 more
openaire   +3 more sources

Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer

Molecular Cancer, 2003
As with other solid tumors, the growth and metastasis of pancreatic cancer is critically dependent on tumor angiogenesis. A major stimulus for a tumor's recruitment of additional blood vessels is cellular hypoxia, a condition which is especially ...
Reber Howard A, Eibl Guido, Duffy John P, Hines Oscar J   +3 more
doaj   +1 more source

Serum vascular endothelial growth factor levels and tumor molecular marker expression in patients with secondary-edematous breast cancer during treatment dynamics

Journal of V. N. Karazin Kharkiv National University: Series Medicine
Background. Secondary-edematous breast cancer is characterized by high aggressiveness and a lack of clear prognostic markers. Studying the role of Vascular Endothelial Growth Factor in relation to the expression of steroid hormone receptors, HER2/neu ...
O.M. Bilyі, N.A. Mitrіaіeva, L.V. Grebinyk, O.V. Slobodianiuk, S.O. Pylypenko   +4 more
doaj   +1 more source

Activity of cabozantinib in radioresistant brain metastases from renal cell carcinoma: two case reports

Journal of Medical Case Reports, 2018
Background Renal cell carcinoma represents 3–5% of adult malignant tumors. Metastases are found in 30–40% of patients and brain metastases occurred in more than 10% of them.
Sylvie Négrier, Guillaume Moriceau, Valéry Attignon, Véronique Haddad, Daniel Pissaloux, Nicole Guerin, Christian Carrie   +6 more
doaj   +1 more source

Anlotinib: A Novel Targeted Drug for Bone and Soft Tissue Sarcoma

Frontiers in Oncology, 2021
Bone and soft tissue sarcomas account for approximately 15% of pediatric solid malignant tumors and 1% of adult solid malignant tumors. There are over 50 subtypes of sarcomas, each of which is notably heterogeneous and manifested by remarkable phenotypic
Shenglong Li, Shenglong Li
doaj   +1 more source

Anti-angiogenic and antioxidant effects of axitinib in human retinal endothelial cells: implications in diabetic retinopathy

Frontiers in Pharmacology
Diabetic retinopathy is a secondary microvascular complication of diabetes mellitus. This disease progresses from two stages, non-proliferative and proliferative diabetic retinopathy, the latter characterized by retinal abnormal angiogenesis ...
Francesca Lazzara, Federica Conti, Pradip K. Sasmal, Shanavas Alikunju, Settimio Rossi, Filippo Drago, Filippo Drago, Chiara Bianca Maria Platania, Chiara Bianca Maria Platania, Claudio Bucolo, Claudio Bucolo   +10 more
doaj   +1 more source

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source