Results 51 to 60 of about 10,420,356 (335)

Influence of hypoxia and neoangiogenesis on the growth of pancreatic cancer

Molecular Cancer, 2003
As with other solid tumors, the growth and metastasis of pancreatic cancer is critically dependent on tumor angiogenesis. A major stimulus for a tumor's recruitment of additional blood vessels is cellular hypoxia, a condition which is especially ...
Reber Howard A, Eibl Guido, Duffy John P, Hines Oscar J   +3 more
doaj   +1 more source

The binding of vascular endothelial growth factor to its receptors is dependent on cell surface-associated heparin-like molecules.

Journal of Biological Chemistry, 1992
Vascular endothelial growth factor (VEGF) induces the proliferation of endothelial cells and is a potent angiogenic factor that binds to heparin. We have therefore studied the effect of heparin upon the interaction of VEGF with its receptors. Heparin, at
H. Gitay-Goren, S. Soker, I. Vlodavsky, G. Neufeld   +3 more
semanticscholar   +1 more source

Identification of Vascular Endothelial Growth Factor Determinants for Binding KDR and FLT-1 Receptors

Journal of Biological Chemistry, 1996
Vascular endothelial growth factor (VEGF) expression in various cell types is induced by hypoxia and other stimuli. VEGF mediates endothelial cell proliferation, angiogenesis, vascular growth, and vascular permeability via the endothelial cell receptors,
B. Keyt, H. V. Nguyen, Lea T. Berleau, Carlos M. Duarte, Jeanie Park, Helen Chen, N. Ferrara   +6 more
semanticscholar   +1 more source

Serum vascular endothelial growth factor levels and tumor molecular marker expression in patients with secondary-edematous breast cancer during treatment dynamics

Journal of V. N. Karazin Kharkiv National University: Series Medicine
Background. Secondary-edematous breast cancer is characterized by high aggressiveness and a lack of clear prognostic markers. Studying the role of Vascular Endothelial Growth Factor in relation to the expression of steroid hormone receptors, HER2/neu ...
O.M. Bilyі, N.A. Mitrіaіeva, L.V. Grebinyk, O.V. Slobodianiuk, S.O. Pylypenko   +4 more
doaj   +1 more source

Structural and functional characterization of the intracellular kinase domain of vascular endothelial growth factor receptor-2 [PDF]

, 2013
Vascular Endothelial Growth Factors (VEGFs) are key players in blood and lymphatic vessel development and homeostasis. The family consists of five members, VEGF-A, -B, -C, -D and placenta growth factor (PLGF).
Manni, Sandro
core   +1 more source

Activity of cabozantinib in radioresistant brain metastases from renal cell carcinoma: two case reports

Journal of Medical Case Reports, 2018
Background Renal cell carcinoma represents 3–5% of adult malignant tumors. Metastases are found in 30–40% of patients and brain metastases occurred in more than 10% of them.
Sylvie Négrier, Guillaume Moriceau, Valéry Attignon, Véronique Haddad, Daniel Pissaloux, Nicole Guerin, Christian Carrie   +6 more
doaj   +1 more source

Anlotinib: A Novel Targeted Drug for Bone and Soft Tissue Sarcoma

Frontiers in Oncology, 2021
Bone and soft tissue sarcomas account for approximately 15% of pediatric solid malignant tumors and 1% of adult solid malignant tumors. There are over 50 subtypes of sarcomas, each of which is notably heterogeneous and manifested by remarkable phenotypic
Shenglong Li, Shenglong Li
doaj   +1 more source

VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia [PDF]

, 2003
Vascular endothelial growth factor (VEGF-A) is a major regulator of blood vessel formation and function. it controls several processes in endothelial cells, such as proliferation, survival, and migration, but it is not known how these are coordinately ...
Shima, D., Christiana Ruhrberg, Betsholtz, C, Jeltsch, M, Abramsson, A., Shima, D, Matthew Golding, Lundkvist, A, Lundkvist, A., Golding, M, David Shima, Ruhrberg, C, Christopher Mitchell, Mitchell, C, Betsholtz, C., Kari Alitalo, Gerhardt, H, Ruhrberg, C., Christer Betsholtz, Golding, M., Jeltsch, M., Holger Gerhardt, Abramsson, A, Alitalo, K, Andrea Lundkvist, Fruttiger, M., Gerhardt, H., Alitalo, K., Alexandra Abramsson, Mitchell, C., Fruttiger, M, Michael Jeltsch, Marcus Fruttiger   +32 more
core   +1 more source

Anti-angiogenic and antioxidant effects of axitinib in human retinal endothelial cells: implications in diabetic retinopathy

Frontiers in Pharmacology
Diabetic retinopathy is a secondary microvascular complication of diabetes mellitus. This disease progresses from two stages, non-proliferative and proliferative diabetic retinopathy, the latter characterized by retinal abnormal angiogenesis ...
Francesca Lazzara, Federica Conti, Pradip K. Sasmal, Shanavas Alikunju, Settimio Rossi, Filippo Drago, Filippo Drago, Chiara Bianca Maria Platania, Chiara Bianca Maria Platania, Claudio Bucolo, Claudio Bucolo   +10 more
doaj   +1 more source

Vascular endothelial growth factor signaling in health and disease: from molecular mechanisms to therapeutic perspectives

Signal Transduction and Targeted Therapy
Vascular endothelial growth factor (VEGF) signaling is a critical regulator of vasculogenesis, angiogenesis, and lymphangiogenesis, processes that are vital for the development of vascular and lymphatic systems, tissue repair, and the maintenance of ...
Chunsik Lee, Myung-Jin Kim, Anil Kumar, Han-Woong Lee, Yun-Long Yang, Yonghwan Kim   +5 more
semanticscholar   +1 more source